Cotcha Yankinov
Bluelight Crew
- Joined
- Jul 21, 2015
- Messages
- 2,952
"If I knew about the extremely high potency, full agonistic properties, potential for DNA related Halogen damage"
On the flip side, if you never found out about the high affinity and never researched then you would be just as likely to be where you are if you had taken mushrooms instead. And if you did start researching mushrooms, you would find something else to obsess over, and we'd be talking about something else. You've said it yourself, you've had problems obsessing before and you were fine until you started researching.
Don't listen to that shroomery guy. Listen to us and Nichols and your doctors... That shroomery guy is the type of person who has great technical knowledge but is incredibly unhelpful because he misses something that's right in his face.
Also he doesn't seem to understand phenethylamine neurotoxicity observed only in animals (MDMA). Psychedelics aren't neurotoxic in animals, and they certainly don't cause DNA damage (that's an old myth). Especially not by being bound to a receptor while it's internalized, I've actually asked a brilliant person about that before and he shot it down. That discussion was in the context of LSD and that one does actually bind pseudo-irreversibly.
That the shroomery guy would compare 5-HT2A agonists and phenethylamines (MDMA) is ridiculous. Once again, people can have great specific technical knowledge but just completely miss basic common sense things.
I'll mention that people get horrible adverse effects with ecstasy and then they go on to recover just fine... there is a whole lot of rumination driving symptoms in those people because of some research showing serotonin neurotoxicity in animals with high dose MDMA regimens.
Then they freak out and say "Oh no, my happiness chemical! I've fried my brain and I'll never be normal again!" Then they come back months later and they're back to normal. God forbid a mind altering drug would cause adverse psychological effects via a mechanism other than utter destruction of all brain cells. But the adverse effects feel like that subjectively, so I guess we can't blame people for thinking that.
5-HT2A receptors really don't matter. I would love to take a 5-HT2A inverse agonist for insomnia. I've taken inverse agonists at 2A before, it's a feature of many common meds... don't freak out as if 2A is necessary for the soul or to feel happiness.. downregulation of 2A is a good thing. 2A is really just necessary for psychedelics.
What you do however seem to have is OCD, which I highly suggest you seek professional treatment for.
On the flip side, if you never found out about the high affinity and never researched then you would be just as likely to be where you are if you had taken mushrooms instead. And if you did start researching mushrooms, you would find something else to obsess over, and we'd be talking about something else. You've said it yourself, you've had problems obsessing before and you were fine until you started researching.
Don't listen to that shroomery guy. Listen to us and Nichols and your doctors... That shroomery guy is the type of person who has great technical knowledge but is incredibly unhelpful because he misses something that's right in his face.
Also he doesn't seem to understand phenethylamine neurotoxicity observed only in animals (MDMA). Psychedelics aren't neurotoxic in animals, and they certainly don't cause DNA damage (that's an old myth). Especially not by being bound to a receptor while it's internalized, I've actually asked a brilliant person about that before and he shot it down. That discussion was in the context of LSD and that one does actually bind pseudo-irreversibly.
That the shroomery guy would compare 5-HT2A agonists and phenethylamines (MDMA) is ridiculous. Once again, people can have great specific technical knowledge but just completely miss basic common sense things.
I'll mention that people get horrible adverse effects with ecstasy and then they go on to recover just fine... there is a whole lot of rumination driving symptoms in those people because of some research showing serotonin neurotoxicity in animals with high dose MDMA regimens.
Then they freak out and say "Oh no, my happiness chemical! I've fried my brain and I'll never be normal again!" Then they come back months later and they're back to normal. God forbid a mind altering drug would cause adverse psychological effects via a mechanism other than utter destruction of all brain cells. But the adverse effects feel like that subjectively, so I guess we can't blame people for thinking that.
5-HT2A receptors really don't matter. I would love to take a 5-HT2A inverse agonist for insomnia. I've taken inverse agonists at 2A before, it's a feature of many common meds... don't freak out as if 2A is necessary for the soul or to feel happiness.. downregulation of 2A is a good thing. 2A is really just necessary for psychedelics.
What you do however seem to have is OCD, which I highly suggest you seek professional treatment for.