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Opioids In pursuit of successfully potentiating Tianeptine Sodium

Chloralhydro

Bluelighter
Joined
Feb 27, 2019
Messages
65
Hello my friends,

been trying to figure out if there's any notable way in which to potentiate tianeptine sodium. It's worth noting that I'm using tianeptine in a strictly recreational fashion, for fun and euphoria, but also for focus and enhanced performance working in both academic and manual labor ways.

So far, the only thing I've found of traditional opioid potentiators that works is Benadryl, however this could be more of a synergy than true potentiation. By potentiation I'm talking about true pharmacological potentiation like with glutethimide(Doriden) and codeine.

Smoking/vaping sources of nicotine is VERY pleasurable, reminds me of oxycodone and nicotine, though again, this is definitely more of just synergy than potentiation.
My question is to my pharmacology experts here in bluelight. Are there any theoretically viable potentiating agents based on the enzymes tianeptine uses? I know its exact method of action is still somewhat unknown and misunderstood. I can't even find the actual enzymes that're involved in tianeptine use.

I'm using this substance orally only; no snorting, IV/IM, sublingual, anal.


I look forward to a good discussion on this hopefully!



God bless,

ChloralHyrdo
 
Tianeptine is a very niche drug, I'm surprised you seem to be getting so much from it. Personally I think that tianeptine is a waste of opiate tolerance, and if your tolerance is still in a manageable state you should stick to more worthwhile opioids like (real) oxy. It's an unreasonably short acting opioid and an antidepressant on top of that. So if you catch a decent habit due to being able to order as much as you want at will, it's going to be a grueling experience to get off of.

Sorry to be a dick, I just really hate tianeptine. I don't know any ways to potentiate it but even if there are effective means, you won't get much more out of this drug from greater bioavailability. It's still going to be a tease of an opioid that never quite has the legs or the punch to be worth it. I have heard of people attempting to inject the sodium, which apparently gives slightly better effects. But the sodium salt quickly turns into a acidic sludge when in contact with water so obviously IV, IM, or any other ROA really, seems really hazardous.
 
It is not possible to potentiate tianeptine the same way one would use glutethimide to potentiate codeine because the narcotic effect of tianeptine is not dependent on an enzymatic pathway (like codeine).
 
Tianeptine is a very niche drug, I'm surprised you seem to be getting so much from it. Personally I think that tianeptine is a waste of opiate tolerance, and if your tolerance is still in a manageable state you should stick to more worthwhile opioids like (real) oxy. It's an unreasonably short acting opioid and an antidepressant on top of that. So if you catch a decent habit due to being able to order as much as you want at will, it's going to be a grueling experience to get off of.

Sorry to be a dick, I just really hate tianeptine. I don't know any ways to potentiate it but even if there are effective means, you won't get much more out of this drug from greater bioavailability. It's still going to be a tease of an opioid that never quite has the legs or the punch to be worth it. I have heard of people attempting to inject the sodium, which apparently gives slightly better effects. But the sodium salt quickly turns into a acidic sludge when in contact with water so obviously IV, IM, or any other ROA really, seems really hazardous.

I enjoyed it for a while in large doses, eventually over a gram per dose, but after I ditched it in 2017 it never seemed the same to me. I think synthesis quality has gone way down since then, who knows. Or perhaps i got sick of it. For a period of time I enoyed it, and have some fond memories of the experiences that I've had on it (due to the stimulating, anxiolytic qualities). Horribly addictive stuff however.
 
I enjoyed it for a while in large doses, eventually over a gram per dose, but after I ditched it in 2017 it never seemed the same to me. I think synthesis quality has gone way down since then, who knows. Or perhaps i got sick of it. For a period of time I enoyed it, and have some fond memories of the experiences that I've had on it (due to the stimulating, anxiolytic qualities). Horribly addictive stuff however.
Yeah I too found it strangely addictive, even though it didn't do much. I didn't get any anxiolytic effects from it personally, but I also don't enjoy benzos and other more subtle anxiolytic drugs have zero effect. It's possible the quality has gone down over the years since the online market is completely unregulated in most parts of the US and other countries. My use of the sodium salt was in 2014-2015.
 
Last edited:
Hello my friends,

been trying to figure out if there's any notable way in which to potentiate tianeptine sodium. It's worth noting that I'm using tianeptine in a strictly recreational fashion, for fun and euphoria, but also for focus and enhanced performance working in both academic and manual labor ways.

So far, the only thing I've found of traditional opioid potentiators that works is Benadryl, however this could be more of a synergy than true potentiation. By potentiation I'm talking about true pharmacological potentiation like with glutethimide(Doriden) and codeine.

Smoking/vaping sources of nicotine is VERY pleasurable, reminds me of oxycodone and nicotine, though again, this is definitely more of just synergy than potentiation.
My question is to my pharmacology experts here in bluelight. Are there any theoretically viable potentiating agents based on the enzymes tianeptine uses? I know its exact method of action is still somewhat unknown and misunderstood. I can't even find the actual enzymes that're involved in tianeptine use.

I'm using this substance orally only; no snorting, IV/IM, sublingual, anal.


I look forward to a good discussion on this hopefully!



God bless,

ChloralHyrdo
I'm surprised there hasn't been more of a reaction to your query.

I came across it on the net . . . probably one of the YT videos that used to (perhaps they still do - haven't looked) praise its efficacy as an anti-depressant. I'm a functional semi-depressed asocial person, all my life. I haven't taken anything (prescription pharmaceuticals) for it other than pot and occasionally opiate pills that came my way off and on. I never got so dependent that when whatever I had ran out that I went looking for more but, looking back, I realize my affinity for opiate pills was due to the anti-depressant effects of opiates in general.

Anyway, with an interest in pharmacology and nootropics . . . as well as nutrition and health supplements . . . I came across tianeptine. I used it for a year and a half. It wasn't long before I was regularly taking 10 or more grams daily. The energy boost and positive state of mind (the high) comes on quickly and lasts maybe three or four hours, so it's easy to go from one or two grams a day to 10 or more. I ended up ordering it from China in kilo quantities since buying it from retail sources in the U.S. got expensive, even though compared to the cost these days it was cheap.

I've seen it mentioned while poking around this forum that the sodium sold these days is less potent than back when I was using it.

I thought I'd found a wonder drug. No mention was ever made, back then, of it's addictive properties, nor was it ever mentioned that it's primary mode of action is that of an opiate receptor agonist. I realized after about two weeks of using it that if I went without any, a strong craving would arise. I'd wake up in the middle of the night needing to snort a little spoon of it. That's the first time I've ever experienced addiction, despite my lifelong very occasional access and use of Vicodin or Tylenol #3's, usually from leftover dentist prescriptions. Also got some very serious pills from a friend dying of cancer. Nevertheless, no matter how strong the pills that came my way, when they ran out I was disappointed, but never went chasing more. I appreciated them but was not addicted or even dependent.

I quit smoking cigarettes after 25 years of steady use. It took a number of failed attempts over the years but I finally succeeded. It was such an ordeal that, since then, addiction has never worried me. I've had it in my head that if someone can quit cigarettes after a lifetime of smoking them, I could quit anything. I once felt scorn for those who, despite the damage their addiction causes, are too weak-willed to quit once the damage becomes glaringly obvious. I suppose I'm still the same, especially with cigarette smokers or drunks.

Tia brought me up short though. I realized quite early that I was addicted to it but cost seemed to be the only downside to using it . . . until I started noticing my ankles and lower legs were swelling from edema. I'm healthy, normal weight 170# and have never had any medical issues. Even smoking cigarettes wasn't affecting me other than finally getting sick of doing something that was obviously so stupid. I'm 77. I quit cigarettes at age 40.

After a year of tia use I had to come to terms with the obvious fact that it was affecting my body in negative ways. I can't remember just what all the physical negative effects were but the edema stands out in my memory. It was getting worse the longer I used tia and the few times I tried to quit left me so miserable, so quickly, that I just kept on. Once it was clear I was killing myself with the stuff I had to choose though. Did I want to live or die? I decided to screw up my courage and make a serious attempt and I did succeed. I had a good stash of etizolam for the effort and used them to knock myself out for the worst of the withdrawals. Took about four days for the worst to be over but it lingered for weeks. It's been five years this February 1st. Craving was mostly over after a couple weeks but since it is an EXCELLENT anti-depressant, without it I soon returned to my normal state of a functional but mildly depressed asocial self. Quitting tia was the most miserable experience I've ever had. My strategy of knocking myself out for the first few days was the key to my getting through it. I recommend this strategy for quitting anything. There is (or was . . . it still should be there) a forum on Reddit called Quitting Tianeptine.

It was developed in France and is sold there and other countries as Stablon. Normal dose is 12.5 mg three times a day. If use is kept at that level, it just may be the best anti-depressant on the market (if it works at that dosage level . . . I wouldn't know :). If ordering it by the jar or larger quantities from chemical companies in China, 12.5 mg. seems ridiculous. I was into gram-sized doses within days and within weeks was taking 10 grams a day, probably more. The sodium, not the sulfate. I did order some sulfate but for whatever reason didn't find it at all satisfying compared to the sodium I'd become used to.

Somewhere between a year and a year and a half of use I took a pinch of Phenibut along with my tia and ended up about ten hours later calling 911 for the first time in my life. I diagnosed myself as having "electrical poisoning" and while hallucinating all night long - trees and almost all vegetation on my property was adorned with what looked like little Christmas lights. Street lights pulsed. Airplane lights and freeway traffic in the distance appeared extremely abnormal. There were other visual effects as well, all of which appeared as real as the laptop on which I'm typing this. Worse though, I felt myself sinking into a deep enervated state which I was expecting to fade as soon as the Sun came up and the neighborhood lights would be turned off. It may sound ridiculous now but such was what I experienced and when my sinking state didn't go away when the Sun came up and instead I continued to sink, I genuinely felt I was dying. I was.

My potassium level was way below the minimum level allowable. Heartbeats depend upon the brain sending signals to the heart and electrolytes have to be within certain ranges for this to happen. Had I not had such strong native health resilience, I could have and by all rights should have died but despite knowing the financial hit of calling 911, what good is one's savings if one is dead? One has to experience such a state to truly understand this I think. I don't have health insurance. Medicaid probably would have covered the $23K it cost for the ambulance call and hospital bills but if you have a house, you no longer will own it once a person gets involved with Medicaid. I don't qualify for Medicare due to lack of sufficient IRS quarters necessary to qualify for Social Security or Medicare. I've lived a free life and stayed as far away as possible from anything to do with the government. I have excellent credit and would have paid the full bill, however the hospital very kindly lowered the total when I wrote their billing department and explained my retired status. They ran me through several scanning machines and took multiple blood draws for various tests. They put me in a lead-lined room (so the nurses said) that was completely darkened and gave me a blindfold. I was insisting that they pull the breakers to disconnect everything electrical anywhere around me and in one way or another they explained why they couldn't do that so for the three days (maybe four) I demanded to be let out of there since I felt I'd jumped from the frying pan into the fire by going to such an electrically intensive environment as a hospital. Obviously once I had a drip in me and my electrolytes had been restored I no longer felt I was dying, but the delusions continued for most of my time there. Multiple stool samples, urine, blood tests. All they found was that my potassium was drastically lower than life allows and . . . reading about potassium/sodium levels later, I may have been out of my mind in a strange but logical way but had I not had sufficient wit left to call 911 I wouldn't be writing this now.

Yet, after this, I continued to use tia for several months more. The only thing different I had done that night was take a small pinch of Phenibut (something I'd never used but with an interest in nootropics had ordered but never used until the night this event occurred.) I don't know what Phenibut had to do with it but that was the only thing I did differently than on any other day or night. The whole thing was so "real" that I'll probably be wondering the rest of my life just what/how/why I experienced what I did. The true reality of it has faded with time but for months following this experience I desperately tried to find anyone who might understand and be able to explain what happened. I even went back to the hospital to try (without success) and talk to the nurses/doctors and see the section with the "lead-lined" rooms. I was trying to sort what was real from what wasn't for a long time following this experience. The potassium issue can cause delusions and hallucinations so I've just settled for that as an explanation but the whole thing was so bizarre that I wanted to understand more about it. For now, my conclusion pretty much rests upon what I've learned what happens when letting electrolytes, particularly potassium, get low. WAY low. I've since come across accounts of people dying or almost dying from extremely low potassium levels and I'm grateful to my good health and what little rationality I had left to call 911 . . . that and the receiving staff who stuck a drip in me as soon as they rolled me into the receiving area. Had they waited to stick a drip in me until they had run some urine & blood tests I could easily have died right then and there, it was that low. That hardly seems sufficient however to explain the incredibly realistic visions and my state of mind through this episode. I've never in life had anything like this occur, either before or since.

I didn't mean to get into such an exhaustive description of my experience with tia but I type amazingly fast and almost always write three times more than I need to. Hopefully someone finds this interesting. I'll just sum up by saying what I meant to say when I started this . . . don't take tia lightly. Someone said they don't sell tia as strong as it was five years ago so there may be more of a margin with it these days. Dunno. If it's not as strong these days, it just would mean (in my case) I would have been taking 20 grams a day instead of 10-12. It's also gotten way more expensive I notice and there are not nearly as many sellers of it as there used to be. It's strange the feds haven't jumped on it like they did with kratom which, in comparison, is laughable. I thought I'd found a wonder drug. I'm from the Sixties and am no stranger to alternate states of consciousness. I'm familiar with extreme psychedelic states but never in any of them have I lost my core awareness that I was simply enjoying (most of the time) an alternate reality. Nor was I a stranger to opiate pills, as I've mentioned. I knew Terence personally and was partially responsible for enticing him over to Rustler's Valley in RSA and even today listen and re-listen to his talks since they remind me where I'm from in this new world of "phone culture." He would be sickened by it, as I am. He didn't call it by its current name of "social media" but he did call it. "Shit brained".

My message is not to say "Never take tia." We have a right to do whatever we want with our consciousness and our bodies. I rather mean to say, don't take tia lightly. It's a very, very strange drug. It's addictiveness is more than just that it hits the opiate receptors. There's more to it, something poisionous that adds an extra dimension to its addictiveness than just its affinity for opiate receptors.

 
Tianeptine is a horrible drug. Unless you take large amounts of it, it really doesn't have much of an opiate action. Even at moderate doses it causes a withdrawal syndrome that I would place as second to the worst next to alcohol withdrawal, as far as my own personal experience.

This is from zaza pills bought at a gas station that I took simply to relax instead of drinking.

It is shitty, and dangerous, and from what everything I've heard the high isn't even worth it.
 
Tianeptine is a horrible drug. Unless you take large amounts of it, it really doesn't have much of an opiate action. Even at moderate doses it causes a withdrawal syndrome that I would place as second to the worst next to alcohol withdrawal, as far as my own personal experience.

This is from zaza pills bought at a gas station that I took simply to relax instead of drinking.

It is shitty, and dangerous, and from what everything I've heard the high isn't even worth it.
Well, actually the "high" is quite something. If one is using it as an opiate, to get a "nod", then yes you're probably right "it isn't even worth it." Opiates seem to have a wide range of effects that vary depending on several things. In my case, the opiate or opioid pills that crossed my path occasionally all seemed to perk me up. I have seen in Mexico the type of opiate user that just wants to nod off into dreamland though so I'm aware of the wide range. I've lived my life in dreamland already so something to get me out of my natural narcosis is attractive. Tia certainly did this.

I've never tried the gas station forms of tia like Zaza so I can't comment on them but since you have, I'll take your word for their effectiveness - not that I would go near them in any event.

Tia got my attention originally for it's advertised anti-depressant qualities. It worked exceedingly well, and quickly. As I mention above, I thought I'd found a wonder drug. There were a lot of new drugs showing up back when I came across tianeptine. Modafinil and its variants, phenibut, etizolam, Addderall, and dozens more. I've lost interest in experimenting with "nootropics" so I don't know the current scene but five to ten years ago these things were really hot topics. The first exposure in my case was the book Life Extension by Dirk and Sandy Shaw. I think that was the book that started the ball rolling with these things and I was keenly interested in supplements that supposedly enhance, extend, or actually originate new capacities. (Actually, that book came out in the 80's so clearly tia has affected my sense of time as well :).
 
I'm surprised there hasn't been more of a reaction to your query.

I came across it on the net . . . probably one of the YT videos that used to (perhaps they still do - haven't looked) praise its efficacy as an anti-depressant. I'm a functional semi-depressed asocial person, all my life. I haven't taken anything (prescription pharmaceuticals) for it other than pot and occasionally opiate pills that came my way off and on. I never got so dependent that when whatever I had ran out that I went looking for more but, looking back, I realize my affinity for opiate pills was due to the anti-depressant effects of opiates in general.

Anyway, with an interest in pharmacology and nootropics . . . as well as nutrition and health supplements . . . I came across tianeptine. I used it for a year and a half. It wasn't long before I was regularly taking 10 or more grams daily. The energy boost and positive state of mind (the high) comes on quickly and lasts maybe three or four hours, so it's easy to go from one or two grams a day to 10 or more. I ended up ordering it from China in kilo quantities since buying it from retail sources in the U.S. got expensive, even though compared to the cost these days it was cheap.

I've seen it mentioned while poking around this forum that the sodium sold these days is less potent than back when I was using it.

I thought I'd found a wonder drug. No mention was ever made, back then, of it's addictive properties, nor was it ever mentioned that it's primary mode of action is that of an opiate receptor agonist. I realized after about two weeks of using it that if I went without any, a strong craving would arise. I'd wake up in the middle of the night needing to snort a little spoon of it. That's the first time I've ever experienced addiction, despite my lifelong very occasional access and use of Vicodin or Tylenol #3's, usually from leftover dentist prescriptions. Also got some very serious pills from a friend dying of cancer. Nevertheless, no matter how strong the pills that came my way, when they ran out I was disappointed, but never went chasing more. I appreciated them but was not addicted or even dependent.

I quit smoking cigarettes after 25 years of steady use. It took a number of failed attempts over the years but I finally succeeded. It was such an ordeal that, since then, addiction has never worried me. I've had it in my head that if someone can quit cigarettes after a lifetime of smoking them, I could quit anything. I once felt scorn for those who, despite the damage their addiction causes, are too weak-willed to quit once the damage becomes glaringly obvious. I suppose I'm still the same, especially with cigarette smokers or drunks.

Tia brought me up short though. I realized quite early that I was addicted to it but cost seemed to be the only downside to using it . . . until I started noticing my ankles and lower legs were swelling from edema. I'm healthy, normal weight 170# and have never had any medical issues. Even smoking cigarettes wasn't affecting me other than finally getting sick of doing something that was obviously so stupid. I'm 77. I quit cigarettes at age 40.

After a year of tia use I had to come to terms with the obvious fact that it was affecting my body in negative ways. I can't remember just what all the physical negative effects were but the edema stands out in my memory. It was getting worse the longer I used tia and the few times I tried to quit left me so miserable, so quickly, that I just kept on. Once it was clear I was killing myself with the stuff I had to choose though. Did I want to live or die? I decided to screw up my courage and make a serious attempt and I did succeed. I had a good stash of etizolam for the effort and used them to knock myself out for the worst of the withdrawals. Took about four days for the worst to be over but it lingered for weeks. It's been five years this February 1st. Craving was mostly over after a couple weeks but since it is an EXCELLENT anti-depressant, without it I soon returned to my normal state of a functional but mildly depressed asocial self. Quitting tia was the most miserable experience I've ever had. My strategy of knocking myself out for the first few days was the key to my getting through it. I recommend this strategy for quitting anything. There is (or was . . . it still should be there) a forum on Reddit called Quitting Tianeptine.

It was developed in France and is sold there and other countries as Stablon. Normal dose is 12.5 mg three times a day. If use is kept at that level, it just may be the best anti-depressant on the market (if it works at that dosage level . . . I wouldn't know :). If ordering it by the jar or larger quantities from chemical companies in China, 12.5 mg. seems ridiculous. I was into gram-sized doses within days and within weeks was taking 10 grams a day, probably more. The sodium, not the sulfate. I did order some sulfate but for whatever reason didn't find it at all satisfying compared to the sodium I'd become used to.

Somewhere between a year and a year and a half of use I took a pinch of Phenibut along with my tia and ended up about ten hours later calling 911 for the first time in my life. I diagnosed myself as having "electrical poisoning" and while hallucinating all night long - trees and almost all vegetation on my property was adorned with what looked like little Christmas lights. Street lights pulsed. Airplane lights and freeway traffic in the distance appeared extremely abnormal. There were other visual effects as well, all of which appeared as real as the laptop on which I'm typing this. Worse though, I felt myself sinking into a deep enervated state which I was expecting to fade as soon as the Sun came up and the neighborhood lights would be turned off. It may sound ridiculous now but such was what I experienced and when my sinking state didn't go away when the Sun came up and instead I continued to sink, I genuinely felt I was dying. I was.

My potassium level was way below the minimum level allowable. Heartbeats depend upon the brain sending signals to the heart and electrolytes have to be within certain ranges for this to happen. Had I not had such strong native health resilience, I could have and by all rights should have died but despite knowing the financial hit of calling 911, what good is one's savings if one is dead? One has to experience such a state to truly understand this I think. I don't have health insurance. Medicaid probably would have covered the $23K it cost for the ambulance call and hospital bills but if you have a house, you no longer will own it once a person gets involved with Medicaid. I don't qualify for Medicare due to lack of sufficient IRS quarters necessary to qualify for Social Security or Medicare. I've lived a free life and stayed as far away as possible from anything to do with the government. I have excellent credit and would have paid the full bill, however the hospital very kindly lowered the total when I wrote their billing department and explained my retired status. They ran me through several scanning machines and took multiple blood draws for various tests. They put me in a lead-lined room (so the nurses said) that was completely darkened and gave me a blindfold. I was insisting that they pull the breakers to disconnect everything electrical anywhere around me and in one way or another they explained why they couldn't do that so for the three days (maybe four) I demanded to be let out of there since I felt I'd jumped from the frying pan into the fire by going to such an electrically intensive environment as a hospital. Obviously once I had a drip in me and my electrolytes had been restored I no longer felt I was dying, but the delusions continued for most of my time there. Multiple stool samples, urine, blood tests. All they found was that my potassium was drastically lower than life allows and . . . reading about potassium/sodium levels later, I may have been out of my mind in a strange but logical way but had I not had sufficient wit left to call 911 I wouldn't be writing this now.

Yet, after this, I continued to use tia for several months more. The only thing different I had done that night was take a small pinch of Phenibut (something I'd never used but with an interest in nootropics had ordered but never used until the night this event occurred.) I don't know what Phenibut had to do with it but that was the only thing I did differently than on any other day or night. The whole thing was so "real" that I'll probably be wondering the rest of my life just what/how/why I experienced what I did. The true reality of it has faded with time but for months following this experience I desperately tried to find anyone who might understand and be able to explain what happened. I even went back to the hospital to try (without success) and talk to the nurses/doctors and see the section with the "lead-lined" rooms. I was trying to sort what was real from what wasn't for a long time following this experience. The potassium issue can cause delusions and hallucinations so I've just settled for that as an explanation but the whole thing was so bizarre that I wanted to understand more about it. For now, my conclusion pretty much rests upon what I've learned what happens when letting electrolytes, particularly potassium, get low. WAY low. I've since come across accounts of people dying or almost dying from extremely low potassium levels and I'm grateful to my good health and what little rationality I had left to call 911 . . . that and the receiving staff who stuck a drip in me as soon as they rolled me into the receiving area. Had they waited to stick a drip in me until they had run some urine & blood tests I could easily have died right then and there, it was that low. That hardly seems sufficient however to explain the incredibly realistic visions and my state of mind through this episode. I've never in life had anything like this occur, either before or since.

I didn't mean to get into such an exhaustive description of my experience with tia but I type amazingly fast and almost always write three times more than I need to. Hopefully someone finds this interesting. I'll just sum up by saying what I meant to say when I started this . . . don't take tia lightly. Someone said they don't sell tia as strong as it was five years ago so there may be more of a margin with it these days. Dunno. If it's not as strong these days, it just would mean (in my case) I would have been taking 20 grams a day instead of 10-12. It's also gotten way more expensive I notice and there are not nearly as many sellers of it as there used to be. It's strange the feds haven't jumped on it like they did with kratom which, in comparison, is laughable. I thought I'd found a wonder drug. I'm from the Sixties and am no stranger to alternate states of consciousness. I'm familiar with extreme psychedelic states but never in any of them have I lost my core awareness that I was simply enjoying (most of the time) an alternate reality. Nor was I a stranger to opiate pills, as I've mentioned. I knew Terence personally and was partially responsible for enticing him over to Rustler's Valley in RSA and even today listen and re-listen to his talks since they remind me where I'm from in this new world of "phone culture." He would be sickened by it, as I am. He didn't call it by its current name of "social media" but he did call it. "Shit brained".

My message is not to say "Never take tia." We have a right to do whatever we want with our consciousness and our bodies. I rather mean to say, don't take tia lightly. It's a very, very strange drug. It's addictiveness is more than just that it hits the opiate receptors. There's more to it, something poisionous that adds an extra dimension to its addictiveness than just its affinity for opiate receptors.

That was quite a mouthful!

The glutaminergic properties of tianeptine is what perhaps makes it different than other opioids. It certainly can have a shine to it and a stimulation that separates it from traditional opioids. It also lacks much of the respiratory depression of typical opioids and rarely causes fatal overdoses (if it did it would have been made a controlled substance years ago).

I had some enjoyable times on tianeptine. And unlike many other opioids, tianeptine doesn't impair my musical ability (specifically in a creative sense).

Simultaneously, I'd say it is horrible stuff and should be avoided. Eventually it leads to misery.
 
That was quite a mouthful!

The glutaminergic properties of tianeptine is what perhaps makes it different than other opioids. It certainly can have a shine to it and a stimulation that separates it from traditional opioids. It also lacks much of the respiratory depression of typical opioids and rarely causes fatal overdoses (if it did it would have been made a controlled substance years ago).

I had some enjoyable times on tianeptine. And unlike many other opioids, tianeptine doesn't impair my musical ability (specifically in a creative sense).

Simultaneously, I'd say it is horrible stuff and should be avoided. Eventually it leads to misery.

I met a guy when I was in alcohol rehab that was probably taking 10 to 15 g of tianeptine a day and he ended up going into withdrawal and tried to kill himself with opiates because of the withdrawal.

When they narcan-ed him and he came back to consciousness, he punched the EMT in the face and asked him why did they save him.

He said it was the worst experience ever. Tia withdrawal. He said heroin withdrawal was nothing compared to Tia withdrawal.
 
That was quite a mouthful!

The glutaminergic properties of tianeptine is what perhaps makes it different than other opioids. It certainly can have a shine to it and a stimulation that separates it from traditional opioids. It also lacks much of the respiratory depression of typical opioids and rarely causes fatal overdoses (if it did it would have been made a controlled substance years ago).

I had some enjoyable times on tianeptine. And unlike many other opioids, tianeptine doesn't impair my musical ability (specifically in a creative sense).

Simultaneously, I'd say it is horrible stuff and should be avoided. Eventually it leads to misery.
I didn't encounter respiratory depression at any point during my sixteen month run, no matter how much I took. I don't remember that it signaled anything like nausea or any other indicator to give me notice that I was taking too much. I think the only thing that limited my use was taking more than necessary to get the effect I was after would have been a waste of money. . . me being a thrifty sort. I think most if not all drugs (fenatyl perhaps being an exception? No experience with it personally.) signal in some way an overdose threshold if only vomiting, but tia, if it has one, didn't signal anything. It didn't take much and didn't last all that long but boy, it made me feel really alive. A little pinch in a shot glass of warm water was my method of use. The damage it did with me, the edema and whatever else, was from the long term use.

It seems logical that tia contributed in some way to my hallucinatory episode, but I had never experienced anything similar at any point in my use of it. The little pinch of phenibut was the only deviation from my normal routine and phenibut doesn't have a reputation for such an effect - plus I'd taken only a tiny amount since I was a stranger to it - so the whole thing is still truly a mystery. Somehow I turned into a human capacitor. Upon arrival, while lying in a side room with a drip in me and while they were assigning me a ward and running a urine test, I had visual access to the desks where staff people sat at monitors. Staring at a monitor I saw it fail. A tech crew came down and did whatever they did to fix it, then left. Staring at it again, the monitor again went blank. Did I somehow cause that? I turned my attention to another monitor and after about 30 seconds, it too went blank. I then went one by one, putting my attention on each monitor within my range of vision and one by one they went blank. After they'd fixed the first monitor and after staring at it after they left and after it again went blank, I had the question in my mind "Did I cause that?" After about fifteen minutes of failing monitors the whole desk staff moved to another part of the large receiving area and used other machines, thinking I suppose they had a localized system failure in their normal work area. I was able to kill every monitor within my range of vision.

After a couple days and in my darkened, lead-lined room I had gained enough energy to walk to the bathroom on the ward. Coming out of the bathroom I stared at the monitor behind the desk at the nurse's station. It took about ten seconds of deliberate concentration and the monitor went TU just like the earlier ones. I had super powers! There was a uniformed security type person on this ward when this happened - watching me of course - and he hot footed it from where he had been standing to the other side of the office area. Did he see what I'd done to the monitor? He definitely saw something that alarmed him. This super power had faded by the time they let me out after three and a half days. Friends picked me up.

There were other phenomena, all having to do in some way with electricity, that went on during that period. What I attributed to the consequence of having strange chemicals in my body became something more, once I noticed how I could kill computer monitors. These experiences went from being explanable by drugs to something more in the category of the paranormal. Some of what I experienced, such as my property vegetation vested with little lights, was clearly hallucinatory - or, I had ventured into an alternate state of perception that perhaps is always there but inaccessable unless certain conditions are met. There were other things though that were truly not hallucinatory. I could repeatedly and with willful intent kill the monitors once I'd noticed that my unintentional focus upon that first one had such an effect. I started doing it deliberately just to confirm that I actually could cause them to fail. Sounds psycho I know. I don't - in fact have never - had anything like this happen in my life. There were other things, all associated in some way with electrically, that went on during this experience. Tia obviously contributed if only with its effect to disrupt my electrolytes to an almost fatal extent, but there was more to the experience than I've mentioned. Quite a bit more, but more description would take this thread from the subject of tia to a thread on the paranormal with tia only in an ancillary role . . . so I'll leave the rest of it for another day. The experience was so drastically different from anything I'd ever experienced that I attempted for many months afterwords to gain a more comprehensive understanding of it. I've pretty much just let the experience recede into that category of events that will never have a good explanation. I no longer . . or very rarely . . . give it any thought until I came across this thread and started remembering and thinking about it. It would be wonderful to come across someone who had had anything similar happen and who might know more. I'd still very much like to get a rational understanding of it. It was far more mysterious than anything I've ever experienced with any drug. Maybe the tropanes could cause or contribute to something like this. This was a Castenada category experience, but I've never taken tropanes so can't compare . . . but the bizarre nature of it all certainly fit within that category. It's still the most inexplicable state of mind and series of experiences I've ever had. I'll always be on the lookout for the possibility of understanding more about what happened to me.
 
I met a guy when I was in alcohol rehab that was probably taking 10 to 15 g of tianeptine a day and he ended up going into withdrawal and tried to kill himself with opiates because of the withdrawal.

When they narcan-ed him and he came back to consciousness, he punched the EMT in the face and asked him why did they save him.

He said it was the worst experience ever. Tia withdrawal. He said heroin withdrawal was nothing compared to Tia withdrawal.
I read the same thing many times on the Reddit forum Quitting Tianeptine. Thanks for the response.
 
I read the same thing many times on the Reddit forum Quitting Tianeptine. Thanks for the response.

I attribute my ability to get through the truly horrible wd experience to my intuitive wisdom in using etizolam in sufficient quantity to stay unconscious (sleeping) through the worst of it. I've wondered why I haven't read more accounts of people using benzos (or anything else that would work in this way) to get through the first few days of misery. I think it would work for anything ,if it worked for tianeptine.

I live a solitary life with a family of adopted cats (I've been involved with TNR work for many years) so it was easier for me than for those with jobs or family members to make going unconscious for several days impractical or impossible. In those cases though, I would just take a week off, check in to a motel, turn off any phones and put a note up to keep the maids away and just sleep. It seemed like a good strategy and it turned out to be an excellent strategy. I highly recommend it for anyone quitting anything.

Unfortunately, etizolam has become impossible to order. Customs stops it at POE so I gave up trying to get more. I find benzos and their close relatives (etizolam is actually not a benzo but a close relative) to be very useful. Despite many years of use (for forcing myself to go to sleep when I'm not sleepy but have to get up early the next morning . . . and for occasional daytime stress relief), I've gone without any for weeks/months at a time without anything other than wishing I had some. In my opinion the "benzo addiction" one reads about seems, to me, highly overblown. Other than just wishing I had some, I have not found going without to be a big deal. As a long-time user, if benzo withdrawal was really a "thing", I would certainly be vulnerable. It's not. At least with me.
 
@MikeSS

Do you think taking all that excess sodium as tianeptine sodium is what caused you to have such low potassium?
 
@MikeSS

Do you think taking all that excess sodium as tianeptine sodium is what caused you to have such low potassium?
That sounds like something quite relevant in a common-sense way and is what I assumed/learned at the time. Without knowing just how it works, I did learn that the body has a sodium/potassium balance that is critical for body function. If genuinely interested I would follow this thought/presumption of mine and of your query with some research . . . internet of course but with some luck, a specialist who knows something about tianeptine. Five years ago it was rare to find a professional who had even heard of tianeptine, much less studied it. Could well be the same situation today.

Although the recommended doses of Stablon are laughable compared to the doses users use in the real world, there may be useful data available through whatever literature was generated during the development of Stablon. I doubt there will be data covering the effects of dosages used by those like me (and anyone else who gets involved with tia), but who knows . . . there may be something useful. More than we know now at any rate.

If related to your line of work or general interest, following up on this question could be very valuable for you and others.

For those seeking relief from depression, tia works wonders. This has to be at least partially the main reason it took no time at all to become addicted to it. Other tia users surely have encountered what I encountered so an understanding of this issue - depression/tianeptine/addiction/body chemistry balances and processes would all be valuable information to become informed about. Finding data sources is probably still difficult since tia is still considered by everyone I've come across to be a substance whose mode of action is "not completely understood" - if they're familiar with tianeptine at all. Whatever the intricacies of tia's action, your question is one very much worth pursuing.
 
@MikeSS

No. I'll never touch the stuff again.

Based on what the manufacturer stated about the zaza's, it was somewhere between 150 and 450 mg max per day total and it caused withdrawal after only taking it for 4 days. Hell no.
 
I'm surprised there hasn't been more of a reaction to your query.

I came across it on the net . . . probably one of the YT videos that used to (perhaps they still do - haven't looked) praise its efficacy as an anti-depressant. I'm a functional semi-depressed asocial person, all my life. I haven't taken anything (prescription pharmaceuticals) for it other than pot and occasionally opiate pills that came my way off and on. I never got so dependent that when whatever I had ran out that I went looking for more but, looking back, I realize my affinity for opiate pills was due to the anti-depressant effects of opiates in general.

Anyway, with an interest in pharmacology and nootropics . . . as well as nutrition and health supplements . . . I came across tianeptine. I used it for a year and a half. It wasn't long before I was regularly taking 10 or more grams daily. The energy boost and positive state of mind (the high) comes on quickly and lasts maybe three or four hours, so it's easy to go from one or two grams a day to 10 or more. I ended up ordering it from China in kilo quantities since buying it from retail sources in the U.S. got expensive, even though compared to the cost these days it was cheap.

I've seen it mentioned while poking around this forum that the sodium sold these days is less potent than back when I was using it.

I thought I'd found a wonder drug. No mention was ever made, back then, of it's addictive properties, nor was it ever mentioned that it's primary mode of action is that of an opiate receptor agonist. I realized after about two weeks of using it that if I went without any, a strong craving would arise. I'd wake up in the middle of the night needing to snort a little spoon of it. That's the first time I've ever experienced addiction, despite my lifelong very occasional access and use of Vicodin or Tylenol #3's, usually from leftover dentist prescriptions. Also got some very serious pills from a friend dying of cancer. Nevertheless, no matter how strong the pills that came my way, when they ran out I was disappointed, but never went chasing more. I appreciated them but was not addicted or even dependent.

I quit smoking cigarettes after 25 years of steady use. It took a number of failed attempts over the years but I finally succeeded. It was such an ordeal that, since then, addiction has never worried me. I've had it in my head that if someone can quit cigarettes after a lifetime of smoking them, I could quit anything. I once felt scorn for those who, despite the damage their addiction causes, are too weak-willed to quit once the damage becomes glaringly obvious. I suppose I'm still the same, especially with cigarette smokers or drunks.

Tia brought me up short though. I realized quite early that I was addicted to it but cost seemed to be the only downside to using it . . . until I started noticing my ankles and lower legs were swelling from edema. I'm healthy, normal weight 170# and have never had any medical issues. Even smoking cigarettes wasn't affecting me other than finally getting sick of doing something that was obviously so stupid. I'm 77. I quit cigarettes at age 40.

After a year of tia use I had to come to terms with the obvious fact that it was affecting my body in negative ways. I can't remember just what all the physical negative effects were but the edema stands out in my memory. It was getting worse the longer I used tia and the few times I tried to quit left me so miserable, so quickly, that I just kept on. Once it was clear I was killing myself with the stuff I had to choose though. Did I want to live or die? I decided to screw up my courage and make a serious attempt and I did succeed. I had a good stash of etizolam for the effort and used them to knock myself out for the worst of the withdrawals. Took about four days for the worst to be over but it lingered for weeks. It's been five years this February 1st. Craving was mostly over after a couple weeks but since it is an EXCELLENT anti-depressant, without it I soon returned to my normal state of a functional but mildly depressed asocial self. Quitting tia was the most miserable experience I've ever had. My strategy of knocking myself out for the first few days was the key to my getting through it. I recommend this strategy for quitting anything. There is (or was . . . it still should be there) a forum on Reddit called Quitting Tianeptine.

It was developed in France and is sold there and other countries as Stablon. Normal dose is 12.5 mg three times a day. If use is kept at that level, it just may be the best anti-depressant on the market (if it works at that dosage level . . . I wouldn't know :). If ordering it by the jar or larger quantities from chemical companies in China, 12.5 mg. seems ridiculous. I was into gram-sized doses within days and within weeks was taking 10 grams a day, probably more. The sodium, not the sulfate. I did order some sulfate but for whatever reason didn't find it at all satisfying compared to the sodium I'd become used to.

Somewhere between a year and a year and a half of use I took a pinch of Phenibut along with my tia and ended up about ten hours later calling 911 for the first time in my life. I diagnosed myself as having "electrical poisoning" and while hallucinating all night long - trees and almost all vegetation on my property was adorned with what looked like little Christmas lights. Street lights pulsed. Airplane lights and freeway traffic in the distance appeared extremely abnormal. There were other visual effects as well, all of which appeared as real as the laptop on which I'm typing this. Worse though, I felt myself sinking into a deep enervated state which I was expecting to fade as soon as the Sun came up and the neighborhood lights would be turned off. It may sound ridiculous now but such was what I experienced and when my sinking state didn't go away when the Sun came up and instead I continued to sink, I genuinely felt I was dying. I was.

My potassium level was way below the minimum level allowable. Heartbeats depend upon the brain sending signals to the heart and electrolytes have to be within certain ranges for this to happen. Had I not had such strong native health resilience, I could have and by all rights should have died but despite knowing the financial hit of calling 911, what good is one's savings if one is dead? One has to experience such a state to truly understand this I think. I don't have health insurance. Medicaid probably would have covered the $23K it cost for the ambulance call and hospital bills but if you have a house, you no longer will own it once a person gets involved with Medicaid. I don't qualify for Medicare due to lack of sufficient IRS quarters necessary to qualify for Social Security or Medicare. I've lived a free life and stayed as far away as possible from anything to do with the government. I have excellent credit and would have paid the full bill, however the hospital very kindly lowered the total when I wrote their billing department and explained my retired status. They ran me through several scanning machines and took multiple blood draws for various tests. They put me in a lead-lined room (so the nurses said) that was completely darkened and gave me a blindfold. I was insisting that they pull the breakers to disconnect everything electrical anywhere around me and in one way or another they explained why they couldn't do that so for the three days (maybe four) I demanded to be let out of there since I felt I'd jumped from the frying pan into the fire by going to such an electrically intensive environment as a hospital. Obviously once I had a drip in me and my electrolytes had been restored I no longer felt I was dying, but the delusions continued for most of my time there. Multiple stool samples, urine, blood tests. All they found was that my potassium was drastically lower than life allows and . . . reading about potassium/sodium levels later, I may have been out of my mind in a strange but logical way but had I not had sufficient wit left to call 911 I wouldn't be writing this now.

Yet, after this, I continued to use tia for several months more. The only thing different I had done that night was take a small pinch of Phenibut (something I'd never used but with an interest in nootropics had ordered but never used until the night this event occurred.) I don't know what Phenibut had to do with it but that was the only thing I did differently than on any other day or night. The whole thing was so "real" that I'll probably be wondering the rest of my life just what/how/why I experienced what I did. The true reality of it has faded with time but for months following this experience I desperately tried to find anyone who might understand and be able to explain what happened. I even went back to the hospital to try (without success) and talk to the nurses/doctors and see the section with the "lead-lined" rooms. I was trying to sort what was real from what wasn't for a long time following this experience. The potassium issue can cause delusions and hallucinations so I've just settled for that as an explanation but the whole thing was so bizarre that I wanted to understand more about it. For now, my conclusion pretty much rests upon what I've learned what happens when letting electrolytes, particularly potassium, get low. WAY low. I've since come across accounts of people dying or almost dying from extremely low potassium levels and I'm grateful to my good health and what little rationality I had left to call 911 . . . that and the receiving staff who stuck a drip in me as soon as they rolled me into the receiving area. Had they waited to stick a drip in me until they had run some urine & blood tests I could easily have died right then and there, it was that low. That hardly seems sufficient however to explain the incredibly realistic visions and my state of mind through this episode. I've never in life had anything like this occur, either before or since.

I didn't mean to get into such an exhaustive description of my experience with tia but I type amazingly fast and almost always write three times more than I need to. Hopefully someone finds this interesting. I'll just sum up by saying what I meant to say when I started this . . . don't take tia lightly. Someone said they don't sell tia as strong as it was five years ago so there may be more of a margin with it these days. Dunno. If it's not as strong these days, it just would mean (in my case) I would have been taking 20 grams a day instead of 10-12. It's also gotten way more expensive I notice and there are not nearly as many sellers of it as there used to be. It's strange the feds haven't jumped on it like they did with kratom which, in comparison, is laughable. I thought I'd found a wonder drug. I'm from the Sixties and am no stranger to alternate states of consciousness. I'm familiar with extreme psychedelic states but never in any of them have I lost my core awareness that I was simply enjoying (most of the time) an alternate reality. Nor was I a stranger to opiate pills, as I've mentioned. I knew Terence personally and was partially responsible for enticing him over to Rustler's Valley in RSA and even today listen and re-listen to his talks since they remind me where I'm from in this new world of "phone culture." He would be sickened by it, as I am. He didn't call it by its current name of "social media" but he did call it. "Shit brained".

My message is not to say "Never take tia." We have a right to do whatever we want with our consciousness and our bodies. I rather mean to say, don't take tia lightly. It's a very, very strange drug. It's addictiveness is more than just that it hits the opiate receptors. There's more to it, something poisionous that adds an extra dimension to its addictiveness than just its affinity for opiate receptors.
Hey man thanks for the reply. I actuallysuccessfully haven't used tia since December. I was doing 30G in roughly 2 weeks so not as bad as you but still was addicted and would wake up with withdrawals. Just couldn't believe how productive and euphoric it could be.

It took 30 10mg methadone pills and probably 10 subutex 8mg to get me off over the course of 3 months and now I'm off the bupe and currently tapering off benzos legally (have a 40mg per day Valium script ATM but it will decrease over two months)
 
Hey man thanks for the reply. I actuallysuccessfully haven't used tia since December. I was doing 30G in roughly 2 weeks so not as bad as you but still was addicted and would wake up with withdrawals. Just couldn't believe how productive and euphoric it could be.

It took 30 10mg methadone pills and probably 10 subutex 8mg to get me off over the course of 3 months and now I'm off the bupe and currently tapering off benzos legally (have a 40mg per day Valium script ATM but it will decrease over two months)
Congrats you fucking lations! And I'm being completely genuine.
 
One good thing I recall is that once I got through two weeks without any, I didn't from then on feel any craving or desire to "take a little nip" or go near it in any way. In quitting cigarettes in the 80's I failed any number of times trying to quit. I could go three or four days and think to myself, "Well, I've quit so I'll just take a puff just to see . . ." And of course I would immediately go from "just one puff" to just one pack almost immediately. I once went three years without smoking and somehow found myself smoking again so it was literally years without smoking before I could confidently say to myself that I'd quit.

This was not the case with tia. The first few days are about as bad as addiction can get and the first couple weeks are not much better but as I recall, after than I had no craving to ever touch it again so I hope this is the same situation (no more temptation to touch it) with you. Congratulations in quitting. You've done yourself a huge favor healthwise.
 
Congrats you fucking lations! And I'm being completely genuine.
Thanks, I sincerely appreciate that. Tia was a wild ride, but I'm glad to be off. I used it because I thought it was better than using "real" drugs (Like: oxy, valium, klonopin, cocaine, amphetamine, lsd, etc.) but it's much more nuanced I learnt. Tia is a narcotic just the same as the rest at gram doses

Took a little lyrica and soma too lol
 
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