Meth is extremely neurotoxic. It basically disentegrates the white matter in parts of your brain. It winds up having a similar physiology and effect that schizoohrenics experience due to their white matter deficiencies.
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Link to schizoohrenic hallucinations, white matter study:
"Abstract
Auditory hallucinations are a frequent symptom in schizophrenia. While functional imaging studies have suggested the association of certain patterns of brain activity with sub-syndromes or single symptoms (e.g. positive symptoms such as hallucinations), there has been only limited evidence from structural imaging or post-mortem studies. In this study, we investigated the relation of local brain structural deficits to severity of auditory hallucinations, particularly in perisylvian areas previously reported to be involved in auditory hallucinations. In order to overcome certain limitations of conventional volumetric methods, we
used deformation-based morphometry (DBM), a novel automated whole-brain morphometric technique, to assess local gray and white matter deficits in structural magnetic resonance images of 85 schizophrenia patients. We found severity of auditory hallucinations to be significantly correlated (P < 0.001) with volume loss in the left transverse temporal gyrus of Heschl (primary auditory cortex) and left (inferior) supramarginal gyrus, as well as middle/inferior right prefrontal gyri. This demonstrates a pattern of distributed structural abnormalities specific for auditory hallucinations and suggests hallucination-specific alterations in areas of a frontotemporal network for processing auditory information and language."
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Heres a link regarding meth abuse and psychosis; in relation to its effects on brain structure:
Methamphetamine-associated psychosis (MAP) involves widespread neurocognitive and molecular deficits, however accurate diagnosis remains challenging. Integrating relationships between biological markers, brain imaging and clinical parameters may provide an improved mechanistic understanding of...
www.nature.com
Note: "MAP" is an acronym for the "methamphetamine psychosis" group in this study.
"Results
We conducted a preliminary study and integrated highly sensitive SRM-based proteomics, profiling 43 proteins in the serum with psychometric measurements and DTI from a primary cohort of 12 MAP, 14 MA, and 16 healthy controls (
Table 1). We explored the hypothesis that serum proteins previously implicated in the pathophysiology of major psychiatric disorders, and those related to candidate inflammatory and metabolic pathways, mediate susceptibility for psychosis with METH abuse, and that
these differences occur in parallel with white matter microstructural alterations in MAP. We further studied the relationship between serum protein levels and DTI to determine how serum protein abundance may relate to altered microstructural integrity in MAP."