Excuse me Ergicmergic, it is not so that pregabalin/gabapentin ups GABA levels in the brain its more the opposite so when you read about these two drugs then you will see that pregabalin lowers the amount of neurotransmitters called Substance P, Glutamate, nor adrenaline and GABA is also lower. I bet that there are more neurotransmitters involved with pregabalin administration, because recreationally why can a dose of lyrica make us feel good so maybe dopamine is also involved.
In studies with pregabalin it was seen that continuous pregabalin administration causes the density of GABA receptors to become higher in that case less GABA can do a better job or better said the preferred job when pregabalin especially would be prescribed more for GAD in the US. For fybromyalgia its prescribed in the US with mixed success, but mainly for those people who start pregabalin and relief is present then this relief extent is higher then 50% in 50% and more cases i read about.
Like mentioned already pregabalin/gabapentin both have a strong interaction with benzo's so for example when you take say 30 mg diazepam before taking pregabalin then with pregabalin 10 mg diazepam can show to be plenty so i would even go as far to say to try 5 mg with pregabalin to see this works out and from there the proper dose can be found. I am not sure about gabapentin, but pregabalin can effectively suppress a benzo withdrawal and i suppose gabapentin too in a high enough dose.
What's more ehh slamming that means injecting right, but why would anybody want to inject lyrica when the bio availability is already higher then 90% taken orally, but i suppose the faster onset of action is desired only in my case taking pregabalin orally takes about 3 hours before effect is good enough, i take my prescribed 900 mg always in one go.
In the beginning feeling the pregabalin high at first and i love it, but day 3 900 mg needed day 4 already 1,500 mg and before i knew it i was taking 3 grams a day sometimes more, but nothing interesting to feel then i started taking what i am allowed to and in about a week the 900 mg could be felt coming from 3 grams in one step, no withdrawals though.
In studies with pregabalin it was seen that continuous pregabalin administration causes the density of GABA receptors to become higher in that case less GABA can do a better job or better said the preferred job when pregabalin especially would be prescribed more for GAD in the US. For fybromyalgia its prescribed in the US with mixed success, but mainly for those people who start pregabalin and relief is present then this relief extent is higher then 50% in 50% and more cases i read about.
Like mentioned already pregabalin/gabapentin both have a strong interaction with benzo's so for example when you take say 30 mg diazepam before taking pregabalin then with pregabalin 10 mg diazepam can show to be plenty so i would even go as far to say to try 5 mg with pregabalin to see this works out and from there the proper dose can be found. I am not sure about gabapentin, but pregabalin can effectively suppress a benzo withdrawal and i suppose gabapentin too in a high enough dose.
What's more ehh slamming that means injecting right, but why would anybody want to inject lyrica when the bio availability is already higher then 90% taken orally, but i suppose the faster onset of action is desired only in my case taking pregabalin orally takes about 3 hours before effect is good enough, i take my prescribed 900 mg always in one go.
In the beginning feeling the pregabalin high at first and i love it, but day 3 900 mg needed day 4 already 1,500 mg and before i knew it i was taking 3 grams a day sometimes more, but nothing interesting to feel then i started taking what i am allowed to and in about a week the 900 mg could be felt coming from 3 grams in one step, no withdrawals though.