Hi Walter,
I'm glad you found my post helpful. I get what you and others are saying about the anger now. When you were talking about anger, I was thinking like rage, but I know what you mean about being irritable all the time. I think all addicts are like this. Between the ups and downs, sleep problems, searching for the drugs and everything else that goes along with addiction it definitely takes it's toll on us.
You will have no problem at all jumping from oxy to sub, that's exactly what it's for. Bupe is what's known as a partial opiate agonist, whereas oxy, hydro, heroin, etc... are full opiate agonist. When you take an oxy, it attaches to the opioid receptors in the brain and activates the receptor. Over time, the body quits making natural opiates (endorphins) and creates a bunch of extra receptors to handle all of the artificial opiates we use. When you quit adding the artificial opiates, the receptors are left empty and you go into withdrawal. As I mentioned, bupe is a partial agonist, and what this means is that it attaches to the receptor, but only partially activates it, so it will keep you out of withdrawal, but does not get you high. If you slowly taper off the bupe, your body will slowly start making natural endorphins and you can get by with minimal withdrawal symptoms. Another thing about bupe, is that it has a much higher affinity for the receptors than most other opiates. What this means is that it has a stronger bind to the receptors than other opiates. This is why if you take oxy while on bupe, you will not get high (you can, but you would have to take a retarded amount). This is also why you have to make sure you are well into withdrawal before taking the bupe. If you still have opiates in your system, the bupe will knock the oxy off the receptors and will put you into withdrawal almost immediately. This is the main reason I suggested starting with a small dose - should you go into precipitated withdrawal, it will not be as bad. What I described to you is exactly what I did, .5mg, then another .5mg an hour later, then .25mg every hour until I was "right". If you do it this way, you should be able to get normal on a very small amount of bupe. I was taking 240mg of oxy a day and I started on 2mg. This was actually the second time I used sub. The first time I did what my doctor said and just started on 16mg. I had terrible headaches and felt really spaced out. The second time I did a bunch of online research and came to realize just how strong the stuff really is. If you start the sub the way I suggested, you will feel normal within an hour of settling on your final dose. The only suffering will be while waiting to take the initial dose. After you get there, you will just feel normal - not high, just normal. I actually got a little natural high the first time, when I realized that I felt like a normal human for the first time in years. I believe it's important to settle on the smallest dose that works. We're addicts and our junkie minds tend to think if 2mg is good, 4mg must be great! Don't fall into this trap. Just keep telling yourself that you're only using the bupe to get clean, not to get high. Also, sub has a 72 hour half life, whereas most opiates have a half life in the range of 2-5 hours. This means you should only need to take sub a max of 2x a day. I did this initially, then went to only 1x a day. Taking drugs all throughout the day is druggie behavior, and I wanted to get as far away from that as I could.
If I can offer any more input or insight, just let me know. I wish you the absolute best my friend!
I'm glad you found my post helpful. I get what you and others are saying about the anger now. When you were talking about anger, I was thinking like rage, but I know what you mean about being irritable all the time. I think all addicts are like this. Between the ups and downs, sleep problems, searching for the drugs and everything else that goes along with addiction it definitely takes it's toll on us.
You will have no problem at all jumping from oxy to sub, that's exactly what it's for. Bupe is what's known as a partial opiate agonist, whereas oxy, hydro, heroin, etc... are full opiate agonist. When you take an oxy, it attaches to the opioid receptors in the brain and activates the receptor. Over time, the body quits making natural opiates (endorphins) and creates a bunch of extra receptors to handle all of the artificial opiates we use. When you quit adding the artificial opiates, the receptors are left empty and you go into withdrawal. As I mentioned, bupe is a partial agonist, and what this means is that it attaches to the receptor, but only partially activates it, so it will keep you out of withdrawal, but does not get you high. If you slowly taper off the bupe, your body will slowly start making natural endorphins and you can get by with minimal withdrawal symptoms. Another thing about bupe, is that it has a much higher affinity for the receptors than most other opiates. What this means is that it has a stronger bind to the receptors than other opiates. This is why if you take oxy while on bupe, you will not get high (you can, but you would have to take a retarded amount). This is also why you have to make sure you are well into withdrawal before taking the bupe. If you still have opiates in your system, the bupe will knock the oxy off the receptors and will put you into withdrawal almost immediately. This is the main reason I suggested starting with a small dose - should you go into precipitated withdrawal, it will not be as bad. What I described to you is exactly what I did, .5mg, then another .5mg an hour later, then .25mg every hour until I was "right". If you do it this way, you should be able to get normal on a very small amount of bupe. I was taking 240mg of oxy a day and I started on 2mg. This was actually the second time I used sub. The first time I did what my doctor said and just started on 16mg. I had terrible headaches and felt really spaced out. The second time I did a bunch of online research and came to realize just how strong the stuff really is. If you start the sub the way I suggested, you will feel normal within an hour of settling on your final dose. The only suffering will be while waiting to take the initial dose. After you get there, you will just feel normal - not high, just normal. I actually got a little natural high the first time, when I realized that I felt like a normal human for the first time in years. I believe it's important to settle on the smallest dose that works. We're addicts and our junkie minds tend to think if 2mg is good, 4mg must be great! Don't fall into this trap. Just keep telling yourself that you're only using the bupe to get clean, not to get high. Also, sub has a 72 hour half life, whereas most opiates have a half life in the range of 2-5 hours. This means you should only need to take sub a max of 2x a day. I did this initially, then went to only 1x a day. Taking drugs all throughout the day is druggie behavior, and I wanted to get as far away from that as I could.
If I can offer any more input or insight, just let me know. I wish you the absolute best my friend!
