Bloody hell's own teeth...I did NOT expect what was meant to simply be a post in a thread for opiate enthusiasts (and addicts, or for that matter, addicted enthusiasts if there is such a thing) to, metaphorically speaking, stir up a similar result to what one would likely get if they were to sit on a hornet's nest with an anal sphincter packed with firecrackers. Damn.
Might as well set things as straight as they are likely going to get then...
To whit:
Mobility-not fantastic. Although its more a matter of pain being the limiting factor rather than anything like paralysis or joints that have a lesser degree of freedom of moment than they are meant to. At least in my hips, bad knee is another matter. So I'm not particularly inclined to twist my hips around just so I can see potential blood in a rig on the off chance that does happen. Thats the first time it ever has, at least shooting into an arse cheek and that I can remember.
Tolerance, 'dick sizing'...let me put it quite simply. I do not see the point of 'dick sizing' with respect to tolerance. It just doesn't make any sense at all to me; to the extent that it honestly wouldn't have ever occurred to me as being 'a thing', its not something theres any point boasting about, even if I was a braggart. I'm not now, never have been and don't see it as being likely in the future short of a radical personality overhaul courtesy of a car crash involving my being hit in the head by a low-flying lamp-post. If I hadn't seen other people talk about it and others still do it and be talked about after the fact, it just wouldn't have registered as relevant.
Tolerance..I've nothing to worry about from 400mg IV morphine. Not a particularly remarkable dose in either direction (I.e large or small, rather than IV vs IM; although I suppose both are true. Yes, I can, if I chose to (and assuming finding a vein is possible) quite easily withstand up to perhaps a gram to 1.5 of dipropionylmorphine [strictly speaking, given some recently read research, given the acid chloride has always been the acylation agent rather than the corresponding anhydride, which have been found to produce quite different results, the product has a high chance of having been rather than solely dipropionylmorphine, a mixture of DPM and 6-monopropionylmorphine along with trace quantities of 3-propionylmorphine and smaller traces of unreacted morphine, although this last cannot possibly have been much going by the histamine release of say, 50-60mg morphine as the sulfate salt compared with the total dose of propionylated esters taken when taking a higher dose) along with of course the IR oxy (generally up to 100-120mg at a time) I get rx'd as a breakthrough pain med.)
But it isn't a thing to boast about. Its merely a function of having had to take strong opioids, in high doses, for a prolonged (many years), if I wish to be mobile without severe pain in my hips from bilateral trochanteric bursitis, a knee that suffered being impaled by a long, very sharp piece of broken glass when I fell on the thing, went right into my joint cavity, and subsequently, more damage inflicted after having surgery, which did not help, and left me with nerve damage.
So one builds up tolerance. Needing that kind of meds at heavy doses for that kind of time periods? you are, short perhaps of using certain specific opioids with very special properties, which are none of them the kind of thing that a GP is capable of providing, and if ever I get the chance to try (such as those that don't induce recruitment of beta-arrestin-2, anything of that kind would require considerable effort, and for most, semisynthesis from products already available (such as naltrexone, or salvinorin-B)
I don't see why in any case being able to tolerate a dose of opioids that would kill most people is something to boast about, or indeed to celebrate (unless, in the case of being celebrated one were to ACCIDENTALLY say, pick up the wrong vial and measure out an overdose for anyone who hadn't such a tolerance. Surviving, thats worth celebrating, but I am not so careless as not to clearly label any such container), its just homeostasis, a function inherent in more or less any organisms biology, be you anything from a human to an eyeless, ghost-pale deep-sea squat-lobster to single-celled amoebae, a plant or a mushroom. Living organisms adapt, mine has, its not something special, anybody else's would undergo the same process of adaptation. And it is not a boon, its a pain in the arse. Yes, I can tolerate a huge dose of morphine sulfate with a fairly large amount of oxy(codone) thrown in when making the shot. So fucking what? it means to get similar effects somebody opioid-nontolerant or with a mild tolerance, I have to take a much greater quantity of the morphine I have available when I'd rather be doing other things with it than ingesting it in some fashion before using it leaving less for experimentation.)
And as for the morphine dose used and however much oxy I'd have thrown in there with it, I'd not have to check whether it were in muscle or vein, in my case tolerance unfortunately has rendered morphine sulfate doses regulated primarily only by size-availability of syringe barrels and for IV use, on histamine release. 1.5g (having to be done as several IV shots, detaching the needle once the first has been delivered, attaching a new one to draw up more until its done) of morphine, or easily 1g dipropionylmorphine (and given that has thus far only been done via the acyl halide rather than anhydride route for acylation, likely a not inactive quantity of 6-monopropionylmorphine would have been present) or a little more in the case of DPM.
But, as I said, to me it means nothing more than an inconvenience of homeostasis. The observation of, IIRC, stee? that I am of a fairly resistant disposition does seem to be the case, I've never been what you could call very sensitive to, in particular, sedative-hypnotics, they work (well most, I have often a paradoxical reaction either to oxazepam or benzos that metabolize to it (delayed in the latter case) and do seem to be able to withstand fairly high dosages of many depressant-type compounds in particular, and am not the easiest of people to sedate. Although the opposite seems true in the case of many stimulants. And I'm hypersensitive to dopamine D2 antagonists and alpha2 adrenoreceptor antagonists, having awful side effects from either, I can't even take the antiemetic domperidone for example, causes awful akathisia, and that particular med is meant not to penetrate the BBB to any particular extent.
Anyhow, it didn't need checking, that 'missed' (or accidentally hit more on target than intended, rather) 400mg morphine [can't remember how much oxy was added to that] isn't going to do me any harm at all, thats actually not all that much, IM, IV or otherwise, so even a 'miss' wasn't going to do any harm.
As for stopping CT, especially from high dose strong opioids like methadone...why would, given the context of the post, would I have mentioned it to caution against OR suggest it (don't, not a good idea, tapering is far safer. Depending on the user there can be health risks. In my case for example if I for some reason am unable to dose (opioids) it seems to lower my seizure threshold a LOT, to the point where it isn't even safe for me to sleep during the briefish period where sleep is possible after last dose and first onset of WD, because I'll wake up into seizures, and ones that are difficult to treat even with sizeable doses of chlormethiazole&nitrazepam)
But I'd suggested nothing about withdrawing, it quite simply was not in context of my post. Oh, and nor did I ever suggest other people take my doses of anything. I'm not, nor do I intend to be or claim to be, responsible for the actions of others, and neither should others base whatever it is they do, on what I might or might not. Whatever others do is their choice, not mine, and I am, as they say, not my brother's keeper. I am just another BL'er amongst thousands. Don't expect me to tell people what they must do (I don't mind warning of dangers if someone's about to screw up big time of course, but don't expect me to tell somebody 'take this, or take that, and how much', and obviously, whilst I can suggest otherwise, I cannot STOP anybody from doing ANYTHING by force. Don't even ask that of me because it is neither my responsibility, nor am I in possession of the capacity to do such a thing.
