It's an adaptation of the book "The Case of the Frozen Addict". It was filmed by Horizon, a BBC documentary channel. Unfortunately it doesn't appear to be available online. NOVA has it listed, but it's not available from there either.
From
NOVA
In July 1982, a 42-year-old addict in a San Jose, California jail became paralyzed—unable to move or talk. His symptoms, caused by a bad batch of synthetic heroin, were indistinguishable from those associated with Parkinson's disease, a degenerative nerve disorder that strikes the elderly. NOVA traces the story of a "designer" drug which could lead to a major medical breakthrough.
Original broadcast date: 02/18/86
Topic: medicine/disease & research
We watched this doco. It may have been aired on the ABC, but it was at least 15 years ago so my memory's a bit fuzzy on exactly what channel it was. However, it is one of the most incredible docos I've ever watched and the story was something neither of us will ever forget.
If you've seen Awakenings with Robin Williams and were touched by it, this story might just do the same. Watching these people reduced to a totally motionless state, is truly heartbreaking. The rapid onset of Parkinson's disease the MPTP-MPPP users experienced was caused by a single exposure to a toxin precursor, rather than from the typical cascade of endogenous processes that normally causes the problem; loss of dopamine cells in the substantia nigra.
In attempting to provide a pharmacological based therapy, L-dopa was administered and the results were extreme. Patients received little comfort, and, as with patients who develop a tolerance to the drug, or for whom the disease advances, responses were typically uncontrollable jerking movements. Very sad.
Then, a Swedish team announced they were doing fetal stem cell transplants. Unfortunately, regular Parkinson's sufferers who received the cells only experienced short term relief. This was determined to be because the underlying mechanisms responsible for initially causing the problem were still present. But with the MPTP patients, the toxin (or toxin precursor) responsible for the ailment was long gone. It had been further metabolised and eliminated shortly after the onset of the disease. In the end all 7 patients received the treatment and all made a complete recovery.
To see these people walking and talking normally after something like 6 years of being completely motionless was about as close to a miracle of science as it gets. A 'curse' and a 'miracle' both brought about by science, the curse being unexpected dehydration of a tertiary alcohol when attempting esterfication to produce the synthetic opioid MPPP (1-methyl-4-phenyl-4-propionoxypiperidine), and stem cell implants resulting in a complete cure.
MPPT
MPTP
To understand more of what happened for those of you who don't know about MPTP or it's metabolic toxin MPP+, check out this paper hosted by Erowid.
1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): One Designer Drug and Serendipity