Lorne???
Bluelight Crew
- Joined
- May 3, 2014
- Messages
- 2,558
As if this thread could hold any more, here's some decent OT stuff though:
The human nose can accommodate a dose of 25-500 uL per nostril
Permeability of the posterior portion of the nose is higher than that of the anterior portion
Slowly absorbing drug should be deposited in the anterior part
Fast absorbing drug in the posterior part of the nose
Increase in the mucociliary clearance rate decreases residence or contact time between drug and the epithelium and reduced drug absorption
Bioadhesives or viscocist enhancers may increase the residence time and increase nasal drug absorption
Ciliated epithelium is present in the middle and upper part of the turbinates
Drugs deposited in the posterior part of the nasal cavity are removed more quickly than a drug deposited in the anterior part of the nasal cavity
Transcellular transport Across cell membranes Favors lipophilic molecules
Paracellular transport Through tight junction between cells
Pores limit molecules to less than 1000 daltons
Yes, though this may beyond the scope of a layman