edit: well I posted the following in the DMT extraction thread about a question regarding this comparison but I think this belongs here in this thread. I'll just leave links in the other thread.
Yes the difference reminds me of the difference between R-ketamine and S-ketamine, it's funny how both sets of compounds complement each other like yin yang.
How I compare N,N-DMT and 5-MeO-DMT, and my theory about the way DMT might work.
Both can get quite physical for me at some times but not that much at other times. When it's strong it's like they say as if an elephant is sitting on my chest. Like experiencing extreme G forces, no wonder the sensation is likened to being shot away strapped to a rocket especially since sometimes it can seem like I am moving at incredible neckbraking velocity.
But considering visuals: 5-MeO-DMT is atypically visual in the way that 5-MeO-MiPT was for me as well: things don't start moving in a funny way, usually, and colors do not really change the way psychedelics usually do for me... rather colors stop being colors but they turn into gradients of energy. All the energy looks basically the same, like beautiful golden light I guess but more like a direct experience of what energy is than just a model that you use in your head. So the gradients are different like I can see that different wavelength light is of different energy omission. The whole thing is a little like a lava lamp where none of the liquids/lava fractions have colors but they do have different densities and only mix partially. You can see something like that if you have a GHB solution and you pour water in. The mental state of 5-MeO-DMT is extreme, emotionally and thematically things all seem to be related to the pure archetypes. Meaning things like heaven and hell, not with any real religious significance in a traditional or cultural way, just the unadultered idea that things are perfect or things are incredibly horrible. Also it is not hard to slip past that duality and feel 'just being'.
I vividly recall one of the first times I took 5-MeO-DMT when it was as if I stepped through a portal into another dimension, which looked exactly the same and there was basically no empirical or explainable reason to say that it was any different than the normal dimension but it felt like a heavenly version of it. Nothing more and nothing less.
DMT
N,N-DMT on the other hand is very visual, as if it triggers my visual databanks to do a memory dump though more interactive than that like imagination coming to life, but imagination on a mostly unconscious level. It can certainly have archetypical elements but for me they tend to often stay in the conceptual realm. Relating to things and ideas that I know and expanding right there on the frontier. The imagery to me is like the impossible made possible. The feeling is like being a stupefied child, forgetting (how to) breathe is common - haha it literally takes my breath away.
Usually the atmosphere is like a fairytale or funhouse, visit the website DMT Nexus and check the forum, at the top there is one of the best style impressions I know... The creatures or entities were to me as often described: playful and cheerful, attentive, compassionate / empathetic, they also had an element of a jester or joker - they seemed to hold in their hands the mysteries of the universe and the power of creation. My idea about this is that they are fractured elements of your own consciousness than span beyond what we normally consider to be the personality, I believe that the entities represent metaprograms ranging from the 'operators' of what are relatively vivid/conscious thought processes to very old instinctual resultants of our own evolution. An analogy might be that we are computers comprised of not only a multi-core machine but more like a distributed network. But that it is not a simple fractal 'hierarchy' or pattern but every node is different and specialized and may have an unique way of approaching stored data.
In somewhat layman terms of neuropharmacology my best guess is that they (the metaprograms) are patterns of brain activity that encode a self-ordering system. I don't think it is something we have 'access' to, except maybe some savants who may have an extraordinary interface with such symbol-based programs. Apparently when some parts of brain function are left uninhibited there can be cross-chatter that allows synaesthesia-like phenomena to do their magic while this may come at the price of another normal part of brain programming. I think that if you take DMT there might be a new carrier wave interacting with regular brain activity that allows similar cross-chatter and interfacing that is normally impossible. IMO it corresponds with the sensation of unlocking the power of the mind (and talking about all the baggage, all the latent information that we inherited - if you include that as well maybe that is what we might call the soul). IIRC, DMT has extraordinary activity in the visual (or general sensory) center of the brain which perhaps in a way catalyzes the abilities of your imagination to the point where all previously mentioned inter-activity could become projected. A sort of central theater... Perhaps the post-central gyrus where the bulk of thalamocortical data is integrated, who knows, this and similar central areas may act as the core receiver - the homunculus could play a role as the 'observer' of the complex experience in attempt to make coherence and sense of all the activity. I also find it suspicious that part of proprioception is also thought to be regulated here and that I for example had an experience where I thought I felt spirits touching my skin causing paraesthesia - I saw them, but it felt like I saw this in an unconventional way, that it was not my eyes sending the information. This fits with my ideas of overflowing activity and abnormal interfacing of consciousness programs.
To some, the entities are perceived as creatures of form, from weird little critters to very alien forms to antropomorphic beings but they are not called self-transforming machine elves for nothing (by McKenna) - I have certainly watched them change into objects or concepts but also saw entities emerge from the 'scenery'. If you ask me the boundary between animate and inanimate is quite vague or they can even be irrelevant / inappropriate terms when it comes to the dimension of the mind. The mechanisms that serve a role trying to make sense of information incorporate programs such as facial recognition or life-form recognition. We have that hard-wired.
So what we experience as entities is IMO probably a projection of our 'entity recognition' program onto other programs, metaprograms and random information that might be flying around, either conjured by the imagination that generates a virtual reality from whatever it can (while automatically trying to stay coherent) or actual sensory data we are receiving. And it makes sense to me that lots of people have described communicating telepathically with the entities. I think that the reason it feels like the impossible becoming possible is because a virtually infinite number of forms of information are "inappropriately" rushing into the integrating switchboard and it constantly yields a resulting sensation of 'does not compute'... before the next stream of boundless experience is presented.
All the while we might sit or lay there in a sort of catatonic state, overwhelmed by the DMT flash. The entities may provide us with priceless lessons and information, that we realize based on information embedded deep within us that is normally protected behind security mechanisms. I have had astonishing contact in which wisdom was bestowed upon me that was only possible to be carried through the channels I have described, I'd call it magical but not in a supernatural way. I think that we all have such a treasure cove deep within ourselves.
A few of the most powerful messages I received were that separation is an illusion and what is fundamental to everything is energy, seen from such a profound perspective the energy felt synonymous with love and to rely heavily on connection, positive connection as is felt with compassion. Another powerful message was that the comfort or better said consolation I needed when my young niece suddenly died seemed to resonate throughout the universe and reverberate back to me, so that I could hug myself and feel some healing. In other trips I overcame the fear of my own death and saw how I can embrace it as part of the cycle of life and death. And the last message I want to tell you about was that I remember having a vision of some kind of universal key, a interpretation or visual simulation of something I later recognized in a documentary as being a way to represent a mathematical phenomenon known as an E8 group.