Naproxen adds to the pain killing effects of opioid to an extent which is greater than the sum of the parts, as is the case with such things as Paracetamol With Codeine Nº 4, Co-Dydramol, Percodan and so on. There are a lot of folks who can notice mild euphoria from naproxen in particular as well as related things like ibuprofen and similar non-steroidal anti-inflammatories -- I get the effect when taking it on an empty stomach even now, and I attribute it to the anti-inflammatory action, as there is also a euphoria which many people get from steroidal anti-inflammatories such as methylprednisolone, dexamethasone, hydrocortisone and so on . . . I can have some effect from prednisone but it is pharmacologically dirty and has lots of side effects, whereas dexamethasone and betamethasone are good clean euphoriants and stimulants. Dexamethasone plus oxycodone is a pretty well known speedball type combination of which doctors and others make a lot of use with a lot of patients to keep their activity level up in the case of lots of conditions being treated.
Naproxen, ibuprofen, ketoprofen, and the like, the propionic acid Nsaids, have this effect the most. The acetic acid Nsaids like diclofenac can have some of it, I have noticed some of the feeling with oxicams, the salicylates have constitutional and weak CNS effects of their own to some extent. I have less experience with fenamates like Ponstel, pyrazolidines like phenybutazone, miscellaneous things like nabumetone, and nimesulide . . . also less effective than naproxen and so forth have been the Cox-2 agents and I do get help from unrelated miscellaneous things like glucosamine & chondroitin, non-Nsaids like paracetamol, topical agents like Ben Gay and so forth are of course different.
They make injectable Nsaids and I have prescriptions for oral naproxen, injectable naproxen, injectable ketorolac (Toradol), and I have found a mixed shot of naproxen, ketorolac, and hydromorphone to be groovy, and I have also mixed naproxen in with shots of Scophedal in the main line.
I read in Frau Im Spiegel magazine some time ago that people who like to suck cock may have an achy feeling afterwards because of the prostaglandin in the baby batter, so they recommend taking ibuprofen before a night of sucking cock. I have no experience with this myself, and pussy juice does not have prostaglandins in it.
Many people say that drugs like prednisone and the others make them want to fight with people, but not me, but then again I have a co-operative and patient and extroverted and morphine-y temperament by default. I was having trouble with my stomach and intestines once on top of my lower back seizing up and gout and was taking betamethasone, methylprednisolone, ciprofloxacin, hyoscine (scopolamine), Deodourised Tincture of Opium stirred into a glass of effervescent multi-vitamins, caffeine, and sodium bicarbonate q i d and ketorolac and oxycodone for it all at once, so by 5.30 every morning I felt like dancing and was going 300 km/h the whole day and needed about three hours of sleep at most. At 22.30 each day it was a big shot of oxymorphone, hydroxyzine, and hyoscine in the arse cheek or inner thigh, optionally SC or IV, but it was uncommon that the combination made me sleepy. They gave me a small number of tablets of nitrazepam, diazepam, and clonazepam to use if I was having trouble sleeping, but did not use them in general as it all didn't really give me the feeling of insomnia per se.
