N&PD Moderators: Skorpio | thegreenhand
Caffeine increases D2 receptor sensitivity
Re: the desoxyn debacle
TL;DR: Stick with the FDA's recommendation to take not more than 5mg at once.
Well to give a bit of an idea for the "magic number" is 0.5mg/kg or 35-40mgish according to a Ricaurte (SP?) study in higher primates. Granted that was just showing significant downregulation of DA markers over about a month. But, there are a lot of unknowns still.
Moral of the story is dose low and avoid using without breaks.
Nomifensine was withdrawn in the US, Canada and the UK for a risk of haemolytic anaemia.[8] Some deaths were linked to immunohaemolytic anemia caused by this compound although the mechanism remained unclear.[9]
Diclofensine was availiable at a few vendors supposedly a few years back - I think it turned out that it was another stupid fucking overhyped drug like naphyrone. The rumor at the time was it induced homosexuality in chimps or something. (n=1 probably ) Of course, it turned out to be another worthless mild stimulant. Perhaps it was fake, or ... who knows. I don't want to touch isoquinolines, personally. Too many of them are neurotoxic or just plain nasty WRT huge fat solubility.
I don't like the aromatic amine in nomifensine - nor the tox shit
Fencamfamine/camfetamine seems an OK stimulant - it's not expected to be as toxic as amphetamine if we go by monoamine release. Basically expect a suped version of methylphenidate.
The lack of an ester group on fencamfamine means you should expect a smoother & longer duration then with methylphenidate.
Fencamfamine's pharmacology has been studied, camfetamine's has not - to my knowledge. I have heard from several places that fencamfamine is relatively benign and well-tolerated. It acts as a reuptake inhibitor with somewhere near 1/10th of amphetamine's effect as a releasing agent.
Fencamfamine (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse.
I know phenmetrazine and probably pemoline are worth checking out too. The Beatles in particular liked phenmetrazine.