jasoncrest
Bluelighter
- Joined
- Sep 15, 2003
- Messages
- 3,952
Beans said:That's incorrect. Actually, grapefruit juice DECREASES the effects of methadone.
mitogen said:Where did you get that from?
Beans is wrong, Grapefruit Juice potentiates Methadone because it inhibits the CYP3A4 enzymes, which metabolize Methadone to inactive metabolites.
So if you drink Grapefruit juice before taking Methadone, there will be less Methadone converted to inactive products -> stronger effect...