Fertile
Bluelighter
- Joined
- Mar 31, 2022
- Messages
- 1,627
If by that you mean does it have a phenyl group, then yes. If you're asking if it's a phenethylamine, then no. It is a CNS stimulant drug of the 2-amino-5-aryl oxazoline class.
I replied to the IMAGE you supplied. Adding a 2,5-dimethoxy and ESPECIALLY a p=Br just meant the body will be deprived on it's main metabolic pathway. People have made p-F 4MAR and the duration is just toooooo long.
So we tried the p-Methyl AR first - because that provides a sacrificial moiety so duration goes down. It also significantly made the compound almost totally SERT selective. Then we made the m-methyl and that was DAT>NET>>SERT. So a 2:1 mixture of the two was an excellent MDMA substitute, but not elegant. Thus having proven the biosteric minimum WOULD fit an MD moiety, we made the 34-MD derivative of aminorex. NOT 4 methylaminorex. Because I am reliably informed (Dr. Dave) that it's an MAOI and so we stayed WELL clear.
If you know 4MAR is a significant MAOI, you would respect the fact that if it's also modulating monoamine release - it's an accident waiting to happen.
PLAIN aminorex is the better scaffold. But it has 5HT2b affinity (as does 4MAR) - so while fine on an occasional basis, long-term use is likely to lead to COPD. Both AR 4MAR have caused COPD in thousands of people. so it's only safe if it's going to be used occasionally. Straight stimulants lead to binges, entactogents rarely.
Read the story of the Florida lab busted for making 4MAR. They had all been using daily for months, they all had COPD, specifically heart valve damage.
So I repeat - people have looked into this scaffold, it's a possible MDMA replacement but as I have already stated - too complex synthetically.
But by all means, provide a facile synthesis and we will continue.