If you'll excuse the phrasing, do you really think I'm pulling this out of my ass? I have better things to lie about than what I put in my butt.
Sorry I was just gonna edit my post because I didn't realize you tried it yourself. The phrasing is actually quite adequate in this situation. :D
The non-ischemic toxicity exhibited by 3F-P on tissue is not the only issue, it's the vasoconstrictive effects which should be on roughly the same level, regardless of concentration.
The problem with amphetamine is that it is much more unreliable when administered rectally, see the above acrticle for reference. For me it barely works at all, despite always having been a huge fan of rectal plugging before I got drawn into the big boys' game.
Regarding the dangers of rectal use of stimulants... A bleeding asshole is quite the testament of that. Your feces come into direct contact with blood and you are running a risk to catch an infection which can have devastating consequences. The fact that you are not six feet under proves nothing which you will be fully aware of.
I would also risk using it rectally myself if it wasn't for the pain and irritation I feel administering certain substances. However when it comes to a substance with such unsettling potential for abuse, recommending rectal use will not only cause people to administer 50mg every now and then, but might instead lead people like noobcakes to use it as an alternative to intravenous use which caused him to wake up amnestic in an apartment that is covered in blood. Just imagine he uses 20g rectally instead of intravenously in his next session... I know what as little as 2g of the chemical spread out over a 2 day session did to my veins and nerves, I can not imagine that the rectum will not suffer clinically significant necrosis, regardless of whether it is caused by a currently unknown toxic mechanism or vasoconstrictive ischemia. As unhealthy as IV use may be, I would personally much rather suffer loss of yet another vein than having a proctectomy performed (removal of your rectum) or suffering a sepsis. Needless to say neither ROA is anywhere near being
safe.
I have a suspicion a moderate volume of water aids absorbtion anyway (3-6mL).
When there is an osmotic gradient across a membrane the aqeous portion of the side that has a lower osmolarity will diffuse towards the side of higher osmolarity. I don't see how this would have the ions carried across the membrane, but I suppose it can be explained somehow. There are so many channels that transport chemicals both actively and passively in the GI tract that there is no telling what is really going on. I have pondered what the optimal concentration of a given substance is for rectal absorption many times, but never reached any conclusion. Good information, thanks.
Me personally, I would not dare to load half a gram of 3F-P into my ass, not after seeing what a tiny bit of missed solution has repeatedly done to my nervous and connective tissue. Keeping the diffusion principle in mind, just imagine the water is resorbed very quickly due to low osmolarity resulting in a physiological osmolarity largely due to the 3F-P cationes inside your rectum. Now take into account the pH fluctuations inside the rectum: I don't have any info on the acid dissociation constants of 3F-P, but imagine the rectal pH is comparably high on a given day and has you end up with freebase 3F-P up the ass. There is no telling what that will do. This will never happen with intranasal or oral use.
I should mention that I confused some facts here. The rectal pH is not subject to large variance, but is in fact quite constant compared to the pH in our urine (5-10 or so I think). It is in fact slightly acidic while most stimulants have pka's north of 8, so deprotonation should not occur to any clinically significant degree.
I maintain if you ate so much as to affect your physiology, you'd still risk acidosis. And me persoanlly, I dislike the taste of it, simple and plain. (but not black liquorice itself, just ammonium salts!)
In the
thread I specifically recommended not to exceed doses that are commonly consumed by salmiak licorice and specified the dosage range. A whole lot of people in Europe consume excessive amounts of salmiak. There are people who eat a shit ton day by day - You'd be surprised!
The problem I had with your statement regarding the taste was that you did not say you 'personally' dislike salmiak, but simply stated that it's "fucking disgusting" even when diluted. It is an additive of some cough syrup preparations to cover the bitterness afaik since it salmiak has a very dominant flavor to it. Even if you didn't mean to talk shit about traditional European food, that wasn't apparent and seemed quite offensive to me.
We are wasting our breath indeed, but you have to understand that it's very disheartening researching a topic for what must have been close to a whole day to put together what I consider life saving harm reduction advice (think loss of driver's license and occupation) and then have the thread deleted months after it's creation despite you having posted there months before it got removed. The last posts were focussing on food and contained no further advice that could have been harmful in any way. Closing it would've been sufficient imho, even though I can understand where you are coming from. You consider it harmful, but there is no evidence that it is at the recommended amounts.
Dosic facit venenum! Most substances we talk about on bluelight are extremely harmful in much smaller amounts.
EDIT: While rectal BA surpasses that of oral or intranasal use in most cases, at least to my knowledge it never reaches the same BA as intravenous injections.
