She took 200mg of mescaline hcl and 350ug of HPBCD complexed 25i-nbome under tongue for 20 minutes, and is having the time of her life, really enjoying it. I took the same, it feels like a 175ug acid trip to me, but alot more pleasurable, wild visuals as well, music sounds the best I've ever heard it.
This is the first time she hasn't gotten any nausea from mescaline hcl, she took it in 50mg doses, every 1/2 hour, she got zero nausea. same for me as well, no nausea at all, not even a hint.
She agrees that the combination 100% feels indistinguishable from acid. She said the trip "is fully mind-manifesting" with the combination of the two. Visuals are out of this world for me. She also said the visuals are just like those of acid visuals, she is having lots of visual activity, same here, the combination is the "cream de la creame" of the psychedelic world.
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I kept a log of the time line for that night:
4:30pm both ate a meal of plain steak/potatoe(no toppings)/corn
6:00pm both of us took 50mg mescaline
6:30pm both of us took 50mg mescaline
7:00pm both of us took 50mg mescaline
7:30pm both of us took 50mg mescaline (200mg total)
7:30pm both of us placed 350ug (mics) of HPBCD complexed 25i-nbome under tongue, held there for 20 minutes, kept saliva/spit in for 10 minutes, then swallowed, but still kept filter paper blotter of 25i-nbome under tongue for full 20minutes, then disposed of paper.
Mescaline was felt coming on first, then the 25i-nbome was felt coming at about 1 hour after placing under tongue.
In the future we will take the 25i-nbome about halfway thru taking the mescaline hcl pills, that way both entheogens will end up coming on at about the same exact time. You can take 50mg mescaline pills (or even 75mg pills) every 1/2 hour, as there is little tolerance to the effects of mescaline, even 1 to 2 hours later, the doses of mescaline have 90% effectiveness of the 1st dose of mescaline you took, you can't do this with LSD or tryptamines.
We were feeling full effects from both substances at 9pm. The peak strong effects of the trip lasted until about 3am in the morning, we were both still lightly tripping till 6am in the morning, we could not sleep, so we both took 1 and 1/2 benadryl, which quickly knocked us both out, we slept a good 6 hours.
We woke up completely refreshed, no headache at all, we both felt a powerful afterglow and had energy to go about cleaning the place, working outside, etc. The normal way you feel after acid or mescaline. No hangover at all.
In short, when you combine both substances, the trip is about the same length as an acid or mescaline trip. We LOVE long trips, we want to enjoy and trip out for as long as possible all night long.
** She has taken 25i-nbome "on it's own" several times in the past, as have I, and we have noticed that it is lacking spiritually, the trip is too short (only lasting 6 hours max with only 4 hours of visuals.)During the trip she referred to 25i-nbome on it's own as "fake Japanese acid" cause it lacks the full mind-manifesting effects of real acid. I would have to agree with her statement.
** when both substances are combined the 5-HT1A, 5-HT1E and 5-HT2B activity of the mescaline "modulates" the powerful visual activity of 25i-nbome (highest ever discovered affinity for 5-HT2A and 5-HT2C, which is responsible for most visual activity and complex behaviors) so that the visuals & thoughts become "meaningful" like real LSD or mescaline visuals. That night, we saw actual archaic/Mayan/complex imagery all over the carpet and walls, even at 5am in the morning, when I closed me eyes, I was still seeing colorful grids and geometric images. The closed and OEV visuals are far more powerful than what you see on acid, and music sounds better than it even dose on acid alone
*** I watched as an actress on my monitor's screensaver morphed and changed into 4 completely different women over a minute's span, normally I would need to take 200ug of acid for this same visual effect.
...you have the exact same GREAT sense of humor as you do on acid, we watched several movies and laughed our butts off and even a scary movie which we were fully engrosed in. It was magnificient. Walking into other rooms, we would psychedelic film of all types of imagery that made sense form all over the place, it was absolutely beautiful, I had a hard time tearing myself away from music as it was the best I'd ever heard it. Believe it or not, but we love the combination even more than acid, it feels even more pleasurable, and colors can be seen we had never seen before on acid. She kept remarking how it would be impossible to tell the hybrid combination apart from acid, I said the same...it was so identical in every way. We said this several times throughout the night, there is really no way I'd be able to differentiate.
25i agonizes the following receptors [the lower the number, the greater the affinity]
5-HT2A (0.044), 5-HT2C (2), 5-HT6 (73), 5-HT2B (231), u opiate (82), kappa opiate [288]
mescaline agonizes the following receptors [4.00 = maximum affinity, 0.00 = no affinity]:
Alpha2c (4.00), 5-HT2B (3.97), 5-HT1A (3.61) Imidazoline1 (3.44), 5-HT1E (3.16), alpha 2a (2.92) and poorly agonizes 5-HT2A & 5-HT2C.
So in other words, 25i-nbome + mescaline looks like this as far as affinity agonism:
5-HT2A, Alpha2c, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1E, 5-HT6, u opiate, kappa opiate, Imidazoline1, alpha2a.
If you want you can go to wikipedia article on "LSD" and scroll down to the middle affinity bar graph, then compare LSD with the above hybrid combination, it is quite similar, and explains so much why the hybrid combination can not be differentiated from an acid trip by either of us.