I do not reccomend using 500 mg mdma in any one night. I would say it is better to space it out between two evenings or days. Personally, I am not a a fan of rolling two days in a row. I agree with the poly-drug users, I usually use lsd, thc, and alprazolam or clonazapam to get the most out of mdma when I do decide to use. I am used to the high of mdma and I fucked up by mixing it with other dopes, and now it is a common deal. I enjoy mdma alone, but honestly I have not used the drug alone in 2 years. In my opinion if you do mdma alone and enjoy it, keep doing it that way, cuz I know it is a lil ignorant to do all those dif. drugs in one evening. I would probably continue with mdma only evenings if I thought it would take me where I want to go. Do not spoil yourself.