Thank you for clarifying. Sorry I missed the fact that you were taking full therapeutic doses of naltrexone. which will certainly interfere with a kratom high. I don’t have any evidence for this, but I wonder if taking chronic high dose naltrexone could cause the substance to accumulate in certain tissues like BodyFat, from where it may be slowly released. if possible, try to discontinue naltrexone. for about a month, before trying kratom again. though you probably already know this, it is recommended to have regular liver function tests. as naltrexone can be harmful to the liver at therapeutic doses.
In regards to my statement about overwhelming drug euphoria, no, I didn’t mean it was a bad thing in itself on an occasional basis. I was just bringing my own experience. and that I’ve heard from others., about the unsustainability of constantly pursuing a drug purely for the euphoria, and having very high expectations about it. I just feel that this can make one miss out on the more subtle, but long-term effects of certain drugs, for example, using them as an enhancer for pleasurable activities, rather than as the sole source of pleasure or main contributor. then again, if you only do it occasionally and you don’t strictly need it to enjoy yourself, I guess there’s no problem getting really high once in a while.
In regards to the stimulant effects you are looking for from kratom, i’m not exactly sure which alkaloid is responsible, but I think it might be Mitragenine as it can affect dopamine transport. The closely related compound and metabolite 7Hydroxi-Mitragenine is a much stronger MU opioid, agonist than Mitragenine and probably contributes to the more sedating/traditional opioid like affects of Kratom.
I definitely understand why you’re looking for the stimulant effects of Kratom. Though I’ve never tried it, i’ve read that the stimulation it produces is simultaneously, very functional and enjoyable, making boring tasks, physical or mental much easier to persist with.
Overall, my advice would be a tolerance break from all drugs you can safely discontinue and do that for at least a month before reintroducing kratom.
Relate to this, are you still using adenosine, antagonist drugs, like caffeine, paraxanthine etc. I know they theoretically potentiate other substances., particularly the stimulant effects, but in my experience caffeine strongly blunts the rewarding and beneficial effects of nicotine.
Good luck