Cocaine isn’t your typical DRI ….like Bupropion (Wellbutrin)
Cocaine is strikingly similar to Methylphenidate (Ritalin), both being classified as “Inverse Aginists” which release monoamines DAT/NET/SERT in addition to inhibiting their reuptake, resulting in Dopamine building up in the CNS
Cocaine is………………….DAT>SERT>>NET (dopamine & serotonin predominant over norepinephrine)
Methylphenidate is……….DAT>NET (3-4x more dopamine release over norepinephrine)
Methylphenidate (Ritalin) is actually nearly twice as potent as Cocaine at DAT (ED-50) effective dose to inhibit 50% of dopamine transporters DAT which is required to experience euphoric effects
That’s why they call Ritalin “Kiddy Coke” as it’s nearly identical in its MOA and given to kids with ADHD
First time trying Ritalin 20mg tablet I was euphoric & happy, robust mood-boosting properties with minimal cardiovascular negative effects such as increased HR & BP. Safer than the typical amphetamine medications, excluding Dexedrine & Desoxyn
So you wanna blast Cocaine and jerk off for maximum dopamine release lol.
Pitter padder…..
You want more pleasurable dopamine release? Take an oral Speedball lol. No, really
Oxycodone 10mg & Methylphenidate 20mg orally administered SUPER EUPHORIC
Cocaine & Heroin I.V. injection ……BOOM 100% Pure Ecstasy
Opioids are SUPER euphoric & pleasurable…adding a dopaminergic stimulant practically Triples the Euphoric Pleasure