I've only ever smoked it personally, and I've definitely had some really weak and janky-looking stuff and some that was really nice and potent. Smoking it treating it as something like low potency cannabis in terms of how much to use is usually enough for me when the quality is good, an old friend and I actually once had something we called "The Summer of Blue Lotus" because I wasn't smoking cannabis at the time so we just smoked blue lotus all summer and consistently got pretty high on it, if I smoke enough it actually does feel somewhat similar to good cannabis to me with the kind of body glow and social laughter except that instead of making my thoughts more active and loud, it makes them feel very distant and almost like I can think in just feelings or pictures, and it's been something I've really enjoyed.
I actually think there's a pretty high chance that being on kratom could cover up the effects of blue lotus especially if you weren't already used to feeling the effects of blue lotus on its own. Not just because kratom is easier to get a stronger buzz on, but because kratom and blue lotus actually share a mechanism of action, and not in the way the way that most people might guess. Everyone pretty much knows by now that mitragynine from kratom is a unique partial mu-opioid receptor agonist that metabolizes into a more potent and typical mu-opioid receptor agonist, 7-hydroxymitragynine, but it actually produces much higher and longer-lasting levels of mitragynine itself in the body nonetheless, and mitragynine also has multiple non-opioid actions, like binding to serotonin, dopamine, and adrenergic receptors in ways that appear to be similar to atypical antipsychotics like clozapine, and it has been investigated scientifically for antipsychotic effects. In the same vein, one of the primary active components of blue lotus that is regularly investigated is nuciferine, which also binds to serotonin, dopamine, and adrenergic receptors in ways seemingly comparable to atypical antipsychotics like clozapine, and has antipsychotic effects when tested, yet also binds to the dopamine transporter and increases amphetamine-induced hyperactivity. I personally consider them both to be in a category of what I would call uniquely euphoric antipsychotics and have explicitly used both to mellow myself out in that way at least a bit, and being familiar with the effects of both I do actually find them to be nice in combination too, so it might be worth familiarizing yourself with blue lotus and then you might get more out of combining it with kratom in the future.
Sounds awesome and I wish you the best of luck! I don't know how much I could do for that but I'd be glad to give some advice where it might help, I certainly have a lot of opinions about what I'd like to be more available and how things can be used. You're welcome to reach out and talk to me any time through PM or whatever.
Wanted to reply to you before because was super interesting but I thought it would take very long and I'm super stressed with a move (boxes everywhere, millions details to solve before tomorrow...) so well, I'll send you a PM later on, when free.
When reading your message I thought about reserpine, which is kind of a yohimbane indole alkaloid similar to mitragynine with and extra group of trimethoxy whatever (not sure how to call it) xD
It has powerful antipsychotic effects and was used to lower high blood pressure. It seems that was used by Gandhi (and a lot of ayurvedic patients) to calm himself, also was used against "crazyness" there, and it has other benefits.. but.. it has a lot of sketchy side effects.
I've used it 3 times, once I used 0.1 grams of rauwolfia serpentina powder (it's main active is reserpine but it has much more actives that supposedly balance out the reserpine), almost nothing happent, then I tried 0.2 and felt much more calm but it wasn't exactly sedating, that's what I was searching...
Then once into a super stupid 2-fma binging I tried to knock out myself with 0.6g of rauwolfia SUCH A MISTAKE... Couldn't sleep that day but surely was zombie-ish and calm, the blood pressure surely went down to a point where, for almost a week, I needed to be extra careful when stood up because, otherwise, I would suffer brutal orthostatic hypotension. Several times I thought I was going to faint, during the first days (its half-life is incredibly long...).
As you can expect, is not an alkaloid to play with, and has other sketchy problems that can appear long-term. I wanted to try, because you know, I love bio-chemistry, but probably that was just too unwary...
In anycase is very interesting in those abstract bio-molecular terms and it has a history linked to the appearance of the first antidepressant and antipsychotic drugs, as lsd is.
Much likely you already knew, but maybe it's interesting for anybody else?
Surely nuciferine is not as hardcore or risky even in high dosages, being a dopamine antagonist (isn't it?).
I know there's nuciferine and aporphine, it would be great to be able to extract both and separate to test them separetely?
Thanks for you explanation, never thought in that relationship and it was clever and very well put, probably it has something to do with some kind of cross-tolerance I didn't think properly before
What do you know about mitragynine pseudo-indoxil? is really what creates the opioid effects along with 7-ohm?
Well, I know this post is a bit off-topic, (could mods move it/erase it?) Let's continue the conversation elsehwhere maybe??
