Not really. As a male user, it definitely started to deplete my testosterone a tiny a bit and low T results in feeling crappy all the time and energy issues. Can cause issues in the bedroom or physically neglected partners.
For the answer you're looking for, probably no... Opiates are surprisingly physically benign in comparison to something like meth. Never noticed things on the internet happening to me like weakened immune system.. etc. I mostly had to depend on it for energy after a year of perpetual use. That was it really. In super high doses... maybe some liver issues. After quitting I actually started growing way more facial hair and it wasn't something I was imagining. Tread carefully though please, It's a really good time