Well then. I've used something between 1 and 1.5g these last 2-3 weeks, in increments of rectal doses between 10 and 30mg. Returns eventually diminished, as obviously expected, and physical discomfort became prominent in the form of headaches, typically preceded by a metallic taste of sorts (vitamin B12 deficits? Just guessing, not a doctor..). Combination with tryptamines sometimes led to blackouts and intense experiences of "universal reset" which may or may not equate to holing, and rather defy description. Combination with alcohol has been notably free of negative consequences, though I must admit to tolerance in this regard. The combo with acid documented above has been the peak experience.
All in all, physical consequences have been of seemingly minor importance during the whole adventure, creeping dysphoria being the largest drawback, brushing too close to mental breakdown for comfort, having to deal with the embarrassment of having made a fool of myself all too often yet again. On the positive side, old hobbies left behind covered with negative associations were resuscitated. In concreto, there have been intensely insane cesspits of chess played these last couple of weeks.
Conclusion: bumpy ride, would repeat. Though this whole ordeal of pioneering crazy new chemical experiences fills me with a yearning for the simplicity of cannabis, which legal and cultural structures make so impractical to enjoy. Feeling pierced right on the edge of the fence here.