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The Big & Dandy Methoxetamine Thread - Hit #12 - Oh look, it's MXE o'clock

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when i smoke on mxe(or any dissociative) i take one toke at a time. and usually don't need more than 2-3 tokes even from the weakest weed even when my weed tolerance is high
 
You people must be REALLY light smokers.. as a seasoned, tolerant everyday type stoner, weed goes AMAZING with MXE for me. I smoke every time I take it, really helps bring out the relaxing and psychedelic properties of the drug.
 
Has tried mixing smaller amounts of MXE (~20mg) or 3-MeO-PCP (~5mg) with a moderate to high dose of MDMA (140-170mg) or 6-APB (120-150mg)? I've read on here somewhere that someone mentioned experiencing serotonin syndrome with MXE and 6-APB (or MDMA, not sure). IIRC, the person used quite a heavy dose of both drugs. I'd be more weary with 3-MeO-PCP considering it has a much wider binding profile than MXE.

Also, weed and MXE can be a risky combo for me that can induce a fair amount of anxiety. Even when I had a high cannabis tolerance I could freakout with this combination. To be fair though, large amount of herb by itself in the right setting can induce anxiety for me.
 
As a rookie pot smoker I can say that fme mxe and weed is actually pretty delightful. Weed tones down the dissociative parts of the experience, and I noticed I was forming more creative ideas than the usual hurr pretty colours mind set mxe can induce
 
mozokev said:
Has tried mixing smaller amounts of MXE (~20mg) or 3-MeO-PCP (~5mg) with a moderate to high dose of MDMA (140-170mg) or 6-APB (120-150mg)? I've read on here somewhere that someone mentioned experiencing serotonin syndrome with MXE and 6-APB (or MDMA, not sure). IIRC, the person used quite a heavy dose of both drugs. I'd be more weary with 3-MeO-PCP considering it has a much wider binding profile than MXE.

Also, weed and MXE can be a risky combo for me that can induce a fair amount of anxiety. Even when I had a high cannabis tolerance I could freakout with this combination. To be fair though, large amount of herb by itself in the right setting can induce anxiety for me.
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I tried ~30mg of MXE orally about 4-6 hours after an initial ingestion of ~125mg 6-APB. It wasn't very enjoyable, to be honest. There were a lot of peripheral "visuals" (thinking you saw something in the corner of your eyes) and very strange auditory hallucinations which were not unpleasant, more so just distracting. I definitely felt "higher" but there was nothing especially profound or fascinating about it. It could be enjoyable in a different environment or with different doses, but I was not especially impressed with the experience. However, though one would assume 6-APB + MXE could be similar to "kittyflipping", I have personally never combined MDMA + Ketamine so I can't compare it in that respect.
 
pot dramatically increased the confusion and sound distortion that was similar to nitrous, it can get scary and personally don't find it more interesting than just more mxe , but everybody has their preference, and as for serotonin syndrome ive combined 6-apb and tramadol with it often and never had problems. in fact buprenorphine/tram/mxe is incredible although a bit potent and very strong at depressing breathing
 
I agree that it can increase the mania of the drug, but that's what I like about it lol. Getting to that state just means I'm high enough for tonight. It's almost a more PCP-esque experience, throw some MXE on a bong hit and it really feels like what I imagine PCP would
 
mozokev said:
Has tried mixing smaller amounts of MXE (~20mg) or 3-MeO-PCP (~5mg) with a moderate to high dose of MDMA (140-170mg) or 6-APB (120-150mg)? I've read on here somewhere that someone mentioned experiencing serotonin syndrome with MXE and 6-APB (or MDMA, not sure). IIRC, the person used quite a heavy dose of both drugs. I'd be more weary with 3-MeO-PCP considering it has a much wider binding profile than MXE.
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I once did 76mg of 6-APDB (not 6-APB, note the 'D') about 18 hours after doing 24mg of 3-MeO-PCP. Both of these were oral doses. I didn't think the two would interact, because I'd gotten a full night of sleep inbetween, but I ended up feeling nauseous and feverish for most of the day, it was pretty unpleasant.
 
THCified said:
Why phenibut with cayenne pepper @ TttS?
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I like to take cayenne pepper regularly. Its good for your body. I figured since I was on a few different substances, it wouldn't hurt. Also cayenne pepper dilates the arteries which i figured might add a bit of a rush to my experience. It is even said to be able to stop heart attacks on the spot, especially if taken with warm water. I usually take a gram at a time every other day or so, sometimes with apple cider vinegar for extra cleansing effects.
 
A gram is a pretty awesome amount of cayenne, do you put it in a capsule or take it straight (hot!). I do hear it is great medicine for a lot of things. Getting back on subject, from my experience taking sublingual MXE after eating something spicy greatly speeds up the absorption and may increase the subligual bioavailability. I first learned this when I dosed right after eating a bunch or spicy 'salt and pepper' potato chips. My mouth was numb and buzzing within a couple minutes!
 
I liked sublingual as I could literally feel the MXE dissolve into my tissue, yet I always needed a little bump of MXE to really kick it in after that and end up doing a lot lol.


Fuck, I want more MXE :p
 
Has anyone had experience with MXE in a live concert setting?

I saw a psychedelic rock band on MXE and it was an incredibly transcendent experience. I don't think I've ever enjoyed live music that much!
 
when all my life was on mxe, i remember had my best party on acid / mxe combo, which was wonderful at least for me, however i guess i was kind of too fuckedup for the majority of people there, was the good old times, and well for coming back to subject as if mxe harmfull or no, i used it from morning to night everyday for probably a year, but ill say it more a mental strenght that u need, i remember i was noting on a notepad every dose and hour i used, try to keep some control and respect about my usage, at the end ill say mxe permitedme to open door in my mind and do things ill never have did without it, at the same time i cant advice anyone to do that, my last word about it will be that it can be the best therapeutic medecine if u up for working on yourself, a great meditative tool but it ask a lot of self control
 
In a previous B&D iteration I mentioned that we need to establish a new institution to effectively handle this complex compound and hopefully advance our understanding of it. I'd like to revisit this notion. What I meant by that is that we ought to collectively analyze all of the data we have from retrospectives, trip reports, combinations with other drugs etc. and develop a 'handbook' of guidelines and conditions in which to best use it, and more importantly when it should NOT be used. For instance, MXE should not be used by giving unmeasured portions to you and your friends after a night of heavy drinking. I think we have enough data to know what that leads to. Most of the world's governments and regulatory agencies haven't made much of any formal response to this drug, so why not take HR matters in our own hands and do our best to properly educate the populace. I mean, this drug is going to be used now and into the future regardless of current or future legality, so I feel like it is the responsibility of the researchers to distill our knowledge base into a form that casual users can consider before using it. What y'all think?
 
30mg sublingual and 2 bowls(1 with mxe on it) got me a ticket to maniaville. i havent slept but am so full of energy and its ridiculous. im gonna stop with the smoking and just stick with mxe because this is too high to be healthy. its incredible though and def pcp-like except im mostly in control. perfect coordination
and everything.
so yes cannabis can be a rollercoaster on this stuff :/
 
How stable is this chemical? If one was having issues with avoiding everyday dosing and wanted to store their mxe in a non climate controlled storage unit in the summer time during 80-90 degree temperatures, would they have to worry about degradation?
 
^I think it's pretty stable. I've had a thin layer of MXE on my scale's weighing tray for at least a month in an upstairs room without air conditioning and there's no signs of a color change like I'd expect there to be if it was degrading. I imaging keeping it in a plastic bag with all the air squeezed out will be sufficient for minimizing oxygen/humidity exposure for the summer.
 
I have to second the warning of going slow with MXE + weed. Earlier this week I passed out for about 10-15 seconds in a state resembling a seizure (as reported by a third party).

This occurred at least 6 hours after administering the last dose of MXE (100mg, after a previous initial dose of 130mg). Needless to say, prior to smoking I had felt pretty close to baseline, other than that residual fuzzy feeling you get during the day following a high dosage. Anyway, at this time 6 hours after the MXE, I smoked a couple of strong joints of hash which had me pretty baked. My whole body started buzzing and I stood up to go inside which caused a headrush. I've been smoking for years and am pretty experienced but knew I had to chill for a while until I was more capable. However, having gone inside and sat down again, this state which was intensified by the headrush only continued to slowly build over a period of a couple minutes. I was seeing stars which proceeded to cloud my vision more and more in a haze of white and also started to sweat profusely. During this time I was able to communicate most of this to a friend and also felt fully aware that I may pass out if it intensified much further. Anyway, I guess it did and I eventually left reality for a brief period in this haze of white in an experience resembling a strong hit of nitrous oxide - minus the euphoria.

After a period of about 10-15 seconds I returned to a very concerned friend. The intensity quickly subsided and I took steps to look after myself in the form of electrolytes and food. During this period I was allegedly slouched back in the chair, with a limp neck, my eyes open and rolled back in my head and not breathing.

I should add that I was pretty sleep deprived and in a fasted state (having been up most of the night due to the prior doses of MXE).

To my layman mind, I feel what may have happened was the beginning of a near-death experience not unlike those outlined by Karl Jansen in his book: Ketamine: Dreams and Realities:
The similarity between NDE and ketamine experiences suggests that
some near-death experiences will be due to blockade of N-P receptors.
241–50, 247–9 A sudden fall in oxygen or blood sugar, which may (for
example) result from interruption of the blood supply during a heart
attack, has been shown to cause a flood release of glutamate.31
Epileptic attacks, head injuries and too much carbon dioxide can also
produce a flood.505–7, 451 Glutamate turns the receptor lock, opening
tunnels so that “the sea” rushes in. The cells swell and burst if the
stimulation is excessive and prolonged. Thus too much glutamate overexcites
cells, which die. Ketamine can prevent the brain damage that
results via the same mechanism that produces psychedelic effects: blockade
of the tunnels so that “the sea” cannot enter.507, 527, 547, 618
This discovery led me to the prediction that the brain would have a
natural protective mechanism against the glutamate flood.241–50, 247–9 This
protection could be a counter-flood of natural tunnel blockers. The
resulting block will produce ketamine-like psychedelic effects as the
two phenomena are linked. While a person is having a NDE the brain
is preserving itself from damage. The link is tunnel blockade, a block
that can happen naturally, for example as a protective brain response
if oxygen falls after a heart attack, or that can be provided by ketamine.
It is this block that can result in a NDE, not the glutamate
flood itself. The degree of damage and the mental state that result depend on the final balance between toxic and protective forces, a
form of battle between “good and evil” played out at the chemical
level.
Patients who were oxygen-deprived for long periods and had
profound near-death experiences sometimes survived the episode with
unimpaired brain function, to the astonishment of their doctors.512 The
lack of damage may result from a very effective mechanism for blocking
over-excitation. So people who can have a NDE are less likely to
suffer brain damage when the blood supply to the brain is cut off.
These may be the same group as those who report “emergence
phenomena” after ketamine. According to Michael Sabom, author of
Recollections of Death: a Medical Investigation, around 40% of the
population have had some form of NDE when the very widest definition
is used, although unpublished work by Peter Fenwick at the
Maudsley hospital in London, indicates a much lower figure amongst
those who had “clinically died!”512 The percentage reporting emergence
phenomena after ketamine anesthesia is also close to 40% in
many studies.1, 213, 328, 456, 460, 513 Until recently, the figure Parke-Davis gave
on their Ketalar® data sheet was 12%. This was too low, and has been
dropped from the latest data sheet.466
A natural tunnel blocker will protect the brain from damage while
generating a state of being that also holds the flood of overwhelming
anxiety at bay. The NDE may be beneficial for the physical brain as
well as having the potential for a positive mental outcome. The benefit
may be even greater where the forces of the psyche give the person
a strong message to “go back” in terms of a mythological drama, and
tell them that it is not their time to go. This might be the final expression
of the deep drive in the mind to survive.
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...but of course I could be wrong. Any comments would be appreciated.
 
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