I recently read some forums posts (see here and here) by an individual named Jox who used the Amazonian Indian medicine kambo to successfully treat his severe chronic fatigue syndrome (CFS). Jox was often bedbound for months with the fatigue and malaise of CFS, but astoundingly, within 2 weeks of taking kambo, he was back to near full health, and remains that way provided he takes kambo once a week. Bear in mind that CFS is generally an incurable condition (and one that is often life-destroying), so this is an incredible result.
Kambo comes from the waxy secretions of the giant leaf frog (Phyllomedusa bicolor) found in the Amazon, and this medicine is usually administered by putting a dab of kambo onto small burns made on your skin, where it is absorbed into the bloodstream.
I myself have CFS, and I would like to know which of the active components in kambo are responsible for this chronic fatigue syndrome cure.
Kambo contains a number of active peptides:
Dermorphin — a potent mu-opioid receptor agonist.
Deltorphin — a very potent delta-opioid receptor agonist.
Phyllomedusin — a tachykinin which affects the salivary glands, tear ducts, intestines, and bowels; it contracts the smooth muscles, and contributes to violent purging.
Phyllokinin (and phyllomedusin) — potent blood vessel dilators that also increase the permeability of the blood-brain barrier.
Phyllocaerulein — which stimulates the adrenal cortex and the pituitary gland, causes a fall in blood pressure accompanied by tachycardia, and has a potent action on the gastrointestinal smooth muscle, and stimulates gastric, biliary and pancreatic secretions.
Sauvagine — causes a long lasting fall in blood pressure, intense tachycardia, and stimulation the adrenal cortex.
Adenoregulin — acts on the adenosine receptors.
Dermaseptin — a potent antimicrobial for both Gram-positive and Gram-negative bacteria.
My initial hunch is that dermorphin and/or deltorphin may be playing a large part in this apparently effective kambo treatment for CFS. This hunch is based on the fact that a low-dose naltrexone protocol, which boosts opioid receptor function, benefits CFS. There is also other evidence that suggests that low endorphin and low opioid receptor function is involved in CFS.
What I am going to do is to try taking dermorphin, to see whether pure dermorphin is an effective treatment for my CFS. I have already obtained 5,000 mcg of dermorphin from a chemical supplier (purity ≥ 95 percent), and I plan to take small doses of this dermorphin intranasally.
I have several questions about taking dermorphin, and would like to get some advice from people on this forum. These questions are as follows:
(1) I read a couple of dermorphin trip reports (here and here) where individuals took 500 mcg of dermorphin intranasally in order to get a psychoactive effect from this drug. In my case, I don't really want the psychoactive effects, so I would like to take a lower dose of dermorphin that is below the threshold for any major mental effects.
Does anyone know roughly what intranasal dose of dermorphin would be below the threshold for psychoactive effects? I am assuming something like 50 mcg of dermorphin intranasally should be without any significant mental effects. My idea is to take this low sub-psychoactive dose on a daily basis, in order to (hopefully) obtain the medicinal benefits, without getting the mental effects.
(2) To take dermorphin intranasally, what I want to do is mix my 5,000 mcg of dermorphin powder with some other inert powder, in a ratio of 1000:1, so that 50 mg of this mixture will contain 50 mcg of dermorphin. This then makes it easier to weigh out doses for snorting. So my question here is: what is a good inert powder to use for this purpose, that will not degrade or react with this rather delicate dermorphin peptide?
(3) When I bought my dermorphin, on the product information note I received from the chemical supplier, it says: "Store peptide in DRY form at 0–5ºC. For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions".
Does anyone know why it says "Do not attempt to weigh out smaller portions. Do not refreeze any unused portions."? Is this because once you open the sealed vial of dermorphin, it lets in humidity, and this moisture then degrades the dermorphin powder? I know that dermorphin is much less stable in water.
I am currently storing my dermorphin in its seal vial in the freezer (temperature around –18ºC), and when I open the sealed dermorphin vial and mix the dermorphin with an inert powder, I am going to put the powder mixture back in the freezer for storage. Will this be OK, do you think? Or will my dermorphin degrade because of moisture exposure?
Kambo comes from the waxy secretions of the giant leaf frog (Phyllomedusa bicolor) found in the Amazon, and this medicine is usually administered by putting a dab of kambo onto small burns made on your skin, where it is absorbed into the bloodstream.
I myself have CFS, and I would like to know which of the active components in kambo are responsible for this chronic fatigue syndrome cure.
Kambo contains a number of active peptides:
Dermorphin — a potent mu-opioid receptor agonist.
Deltorphin — a very potent delta-opioid receptor agonist.
Phyllomedusin — a tachykinin which affects the salivary glands, tear ducts, intestines, and bowels; it contracts the smooth muscles, and contributes to violent purging.
Phyllokinin (and phyllomedusin) — potent blood vessel dilators that also increase the permeability of the blood-brain barrier.
Phyllocaerulein — which stimulates the adrenal cortex and the pituitary gland, causes a fall in blood pressure accompanied by tachycardia, and has a potent action on the gastrointestinal smooth muscle, and stimulates gastric, biliary and pancreatic secretions.
Sauvagine — causes a long lasting fall in blood pressure, intense tachycardia, and stimulation the adrenal cortex.
Adenoregulin — acts on the adenosine receptors.
Dermaseptin — a potent antimicrobial for both Gram-positive and Gram-negative bacteria.
My initial hunch is that dermorphin and/or deltorphin may be playing a large part in this apparently effective kambo treatment for CFS. This hunch is based on the fact that a low-dose naltrexone protocol, which boosts opioid receptor function, benefits CFS. There is also other evidence that suggests that low endorphin and low opioid receptor function is involved in CFS.
What I am going to do is to try taking dermorphin, to see whether pure dermorphin is an effective treatment for my CFS. I have already obtained 5,000 mcg of dermorphin from a chemical supplier (purity ≥ 95 percent), and I plan to take small doses of this dermorphin intranasally.
I have several questions about taking dermorphin, and would like to get some advice from people on this forum. These questions are as follows:
(1) I read a couple of dermorphin trip reports (here and here) where individuals took 500 mcg of dermorphin intranasally in order to get a psychoactive effect from this drug. In my case, I don't really want the psychoactive effects, so I would like to take a lower dose of dermorphin that is below the threshold for any major mental effects.
Does anyone know roughly what intranasal dose of dermorphin would be below the threshold for psychoactive effects? I am assuming something like 50 mcg of dermorphin intranasally should be without any significant mental effects. My idea is to take this low sub-psychoactive dose on a daily basis, in order to (hopefully) obtain the medicinal benefits, without getting the mental effects.
(2) To take dermorphin intranasally, what I want to do is mix my 5,000 mcg of dermorphin powder with some other inert powder, in a ratio of 1000:1, so that 50 mg of this mixture will contain 50 mcg of dermorphin. This then makes it easier to weigh out doses for snorting. So my question here is: what is a good inert powder to use for this purpose, that will not degrade or react with this rather delicate dermorphin peptide?
(3) When I bought my dermorphin, on the product information note I received from the chemical supplier, it says: "Store peptide in DRY form at 0–5ºC. For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions".
Does anyone know why it says "Do not attempt to weigh out smaller portions. Do not refreeze any unused portions."? Is this because once you open the sealed vial of dermorphin, it lets in humidity, and this moisture then degrades the dermorphin powder? I know that dermorphin is much less stable in water.
I am currently storing my dermorphin in its seal vial in the freezer (temperature around –18ºC), and when I open the sealed dermorphin vial and mix the dermorphin with an inert powder, I am going to put the powder mixture back in the freezer for storage. Will this be OK, do you think? Or will my dermorphin degrade because of moisture exposure?
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