High dose (600mg xr) Seroquel + Opiates (hydrocodone)

[alt 14]

Is it safe to mix them? Found it challenging to find source of contraindications, but perhaps I am just not a good operator of searches. From when I read, it may "knock me on my ass" and slow my heartbeat down enough to nod out and never come to? But this is from yahoo answers, and I take it with a grain of salt.

What, if any, interaction between the meds will there be? Do I need to adjust the dose from my typical once-a-month dose of 40mg? Opiates scare the shit out of me tbh especially when mixing it with other drugs, so I will not be repeating the actions of my previous thread Seroquel + Cocaine where I simply dove in head first and THEN read my thread.

Thanks.

 

[paranoid android]

Are you taking the seroquel XR for any specific reason or are you just taking it thinking you will get high off it? For one thing the most you are supposed to take in one night if you are not on it already is 100mg's. 600mg's of seroquel could cause Akathisia or other EPS symptoms and since the XR releases over 24 hours the symptoms could last all fucking day unless you went to the hospital where you would have to explain why you took 600mg's of seroquel.

This is not even mentioning the fact that combing opiates and seroquel at that dose could easily cause fatal respiratory depression. I have been on 300-400mg's of seroquel a day for years along with opiates and if i have to take extra seroquel i will slack off my nightly dose of opiates. So for the love of god and for the sake of harm reduction don't do it. Also seroquel even at really low doses of say 50mg's will ruin a opiate high.

Why you thought taking 600mg's of seroquel alone much less with anything would be a good idea is beyond me. Unless you are prescribed it for bipolar disorder, Major depressive disorder, schizophrenia, etc don't take seroquel! It's a anti-psychotic not a recreational drug.

 

[alt 14]

I'm schizophrenic with signs of Bipolar. Umm afaik the most prescribed in a night is 1000mg, not 100. I know for a fact the largest tablets are 400mg and also that I can safely take up to 600mg xr because, well, that's what the doctor prescribed.

Ok, you say two different things and I am kind of confused. On one hand you said it said it may cause fatal respiratory depression, and on the other, you say you were on 400mg, a dose not too far from mine, and used opiates. Are you kind of saying "do as I say not as I do," or is it more like "if you're used to that much seroquel and wait 24hours after your last dose, and you skip your next dose, you will be perfectly fine?" Or what?


Need more thorough answers please and thanks!

P.S. If if matters, I take my pills in the PM and have only ever missed one dose which was last week some time. And the last dose was at about 10PM, planning to take the opes if it turns out I even can around 8-10pm EST, and simply going to skip the seroquel tonight and take it tmrw night because after a little more reading I read "don't take seroquel even when you're coming down off your opiates." But it was not from a good source, so I really would like to have a definite answer.

 

[Venrak]

You would expect less euphoria due to DAR antagonism, and more sedation as well. It is metabolized extensively by CYP3A4, but metabolites are extensively metabolized by CYP2D6, so there probably will be strong depressant effects.

You will not be as euphoric as you would without the quetiapine, respiratory depression may be even more pronounced, so I would avoid this one too.

Sorry bud.

 

[hangyourhead]

Yeah, I agree with the mods. Seroquel + Opioids is no good!

Believe me I've done this cocktail. I'm not prescribed quetiapine for any reason, just had some I got from a buddy for sleepless nights. Thought since like 25mg and below it acts like a strong H1 antagonist antihistamine I would get some nice sedative potentiation, but all I did was make myself a sleeping zombie and it definitely subtracted a major part of the opioid euphoria and dulled the rush.... Don't do it, especially if you're not prescribed the Seroquel for any reason.

 

[RobotRipping]

i agree, even if it's not dangerous, it's a shitty combo, i don't know why people try to use seroquel recreationally. I was reading on wikipedia about people using seroquel and cocaine together (Q-balls), what the fuck lol.

Seroquel, being a dopamine antagonist is gonna kill your high. If you want potentiation go for promethazine or hydroxyzine. Unless being a zombie, trapped in a human body is your idea of fun, i wouldn't bother with seroquel.

 

[paranoid android]

^ It's not a very strong dopamine antagonist but it's effects on other receptors such as it's very potent H1 antagonism is more then enough to kill any high. Oddly enough i found ye old Thorazine to potentiate opiates and i have used it with morphine and dilaudid to stop the severe nausea and vomiting i get from pain. I certainly wouldn't recommend it though as it does render most people a walking zombie and it's also very dangerous. The Q ball thing really astonishes me and pisses me off at the same time as it's such a waste of coke. I wonder how popular it is though? I have heard of some weird combos before that work for some reason such as T's and Blues which is shooting Talwin and tripelennamine together and T's which is and R's shoting Talwin and Ritalin together. But as for taking seroquel to potentiate opiates it's the strong anti-histamine effects that makes you drowsy so you would be much better off getting a anti-histamine such as doxylamine or hydroxyzine to take with opiates.

To the OP: What i meant was and i should have been much clearer on this is that starting off (as in you have never taken seroquel before) 100mg's is supposed to be the max dose you start out on. Though many doctors think nothing of slapping someone on 300mg's right away. I have been on seroquel on and off for a long time so i have a tolerance to it. I also have been on opiates since about 2006 so i have quite the tolerance to them as well. I thought you where a newbie asking can i get high off seroquel or whatever so i apologize for that.

 

[RobotRipping]

haha talwin and ritalin, that's a strange combo i've never heard of. Ts and blues i can understand but MPH is probably the least recreational stimulant i've ever tried.

For Ts and blues, isn't h1 antagonism responsible for the increase in euphoria? i can't find much info on it but in general h1 antagonists (your regular old school anithistamines, not the 2nd/3rd gen ones tho) potentiate opiates. Perhaps that's more of an indirect effect due to certain enzymes though? i don't know.

seroquel has a hell of a binding affinity at h1 but its metabolite is a much stronger d1 antagonist as well as an h1 antagonist.

from what i gather blocking dopamine release on a rat won't stop it from seeking out opiates (which would suggest that dopamine isn't solely responsbile for the majority of the high), tho it will decrease the desire to so. And h1 antagonism with promethazine, cyclizine, hydroxyzine and friends potentiate (most) opiates, so that would suggest that seroquel along with an opiate wouldn't kill the high and if so, not by a significant amount. Kind of a bit off topic but that may explain why some people for whatever reason use seroquel with opiates to get high/er.

I have no idea why someone would mix seroquel with a dopamine releaser or reupate inhibitor like cocaine though, seems counterproductive yet people still do it.

 

[paranoid android]

haha talwin and ritalin, that's a strange combo i've never heard of. Ts and blues i can understand but MPH is probably the least recreational stimulant i've ever tried.

For Ts and blues, isn't h1 antagonism responsible for the increase in euphoria? i can't find much info on it but in general h1 antagonists (your regular old school anithistamines, not the 2nd/3rd gen ones tho) potentiate opiates. Perhaps that's more of an indirect effect due to certain enzymes though? i don't know.

seroquel has a hell of a binding affinity at h1 but its metabolite is a much stronger d1 antagonist as well as an h1 antagonist.

from what i gather blocking dopamine release on a rat won't stop it from seeking out opiates (which would suggest that dopamine isn't solely responsbile for the majority of the high), tho it will decrease the desire to so. And h1 antagonism with promethazine, cyclizine, hydroxyzine and friends potentiate (most) opiates, so that would suggest that seroquel along with an opiate wouldn't kill the high and if so, not by a significant amount. Kind of a bit off topic but that may explain why some people for whatever reason use seroquel with opiates to get high/er.

I have no idea why someone would mix seroquel with a dopamine releaser or reupate inhibitor like cocaine though, seems counterproductive yet people still do it.

With the Talwin and tripelennamine combo there may be something else to it besides the H1 antagonism as it's supposed to increase the euphoria alot more then say diphenhydramine. Cyclizine is supposed to be awesome with opiates and it was in the famous Diconal mixture which is Dipipanone a strong relative of methadone and cyclizine all in one pill. Diconal is pretty much off the market altogether in the UK due to the amount of abuse around it. It was supposedly the king of opiates and people have since mixed cyclizine with their methadone to try and replicate the Diconal high. too bad cyclizine is not available in Canada

I find that seroquel fucks the high right up but that could be because it lowers my blood pressure when i first take it.