Stimulants Wellbutrin (does it cause seizures w hen mixed with meth?

[twyleskyles]

I want to know if it's likely or it just might?

 

[brighton]

Possibly - I used an online drug interaction checker -

2 Interactions Found
Significant - Monitor Closely

bupropion + methamphetamine =

bupropion will increase the level or effect of methamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Significant - Monitor Closely.

methamphetamine + bupropion =

methamphetamine increases toxcity of bupropion by unspecified interaction mechanism. Significant - Monitor Closely. May lower seizure threshold; keep bupropion dose as low as possible.

 

[Username123]

Depends on how likely you are to have a seizure generally.

Say you have a probability P to have a seizure.

Wellbutrin will increase that probability by W.

Meth will increase that probability by M.

So your probability of a seizure whilst on both meth and wellbutrin will be your base probability multiplied by however much bupropion and meth would increase the risk in your case (P*W*M)--this varies on an individual basis. So nobody can necessarily determine whether or not a seizure on that combination would be likely for you, but there will be an increased risk for one.

 

[AlphaMethylPhenyl]

the answer is yes

both are potent CNS stimulants

bupropion in particular is known for lowering the seizure threshold, which is why its not prescribed over 450mg

 

[tricomb]

Do NOT combine them.

 

[Sweet P]

I actually have had a seizure when combining meth and bupropion, so yes, it's likely.

 

[Coraline]

Yes. It can increase your chances for seizures. And strangely enough I also read that Wellbutrin decreases the urges to do meth. I'm sure they mean when your not taking them at the same time.