4-trifluoromethylamphetamine? Possible properties?

[atrollappears]

Hey, I was wondering why 4-trifluoromethylamphetamine has never been synthed. I'd suspect strong serotonergic effects and probably less neurotoxicity than para-bromo which it would most closely resemble, chemically... Anyone ever heard of it? Google yields nothing.

 

[Astavats]

It's been made and studied. The similarity with fenfluramine and norfenfluramine may explain why it hasn't made a return though.

- Toxic retinopathy following prolonged treatment with dl-p-trifluoromethylphenyl isopropylamine hydrochloride P-1727 in experimental animals (free)
- Anorexigenic Agents: Aromatic Substituted 1-Phenyl-2-propylamines
- Directional nature of hydrophobic bonding in phenethanolamine N-methyl transferase inhibitors
- Inhibition of phenethanolamine N-methyl transferase by ring-substituted alpha-methylphenethylamines (amphetamines) (free)

Synonyms: "P-1727, trifluorex, triflutamine"

 

[atrollappears]

Oh jeez that looks dangerous. Even so, any info on short term effects? I'm not very familiar with n-methyl transferase, but none of those things look like they would stop the drug from being some sort of reinforcing serotonin/dopamine releasing agent.