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Zolpidem base & Uses.

monstanoodle

monstanoodle

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Is it able to produce from tartrate?

Would there be any benefits compared to base form?

Pointless?

If chemmo's could have a think there will be:

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-and-

cake-8inch.jpg


:) cheers
 
The cake is a lie!

(ok, geek joke there)

Umm. I don't see any benefit in having zolpidem base, unless you wanted to smoke it and get to sleep REALLY FAST ~!1! lol.
You could quite easily produce it from the tartrate though, yes.
 
The cake is a lie!
Click to expand...

lol.

it's all a geek joke!

But I can see a benefit of smoking it. People smoke methaqualone, so there's obviously some point to smoking depressants, and zolpidem makes a lot more sense to me than methaqualone does.
 
I don't call Z-drugs recreational, really, they aren't euphoric like benzos can be (IME). Methaqualone is a funny one, I still haven't seen a good explanation of it's method of action... it sounds fun though!
 
Well, I don't really consider benzos euphoric, either. I think zolpidem is probably the best of the bunch, though.
 
It's euphoric nature is here and there... some people don't get any at all from it. It seems to do so more often when snorted, but I do get a slight euphoria from it.
 
Those Z drugs

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zolpidem.gif
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I seem to remember that they bind with a subreceptor (GABA B?) hence hypnotic, but not muscle relaxant or anxiolytic in any great measure.
 
I thought they bound to the same receptors that benzos did, but with more selectivity?

It's really pretty amazing how many different alterations on the 6 side-5 side motif can result in such similarly active drugs. Do you suppose that you could have an indole core, or does there need to be an N on the 6 sided ring?

I always found to be incredibly anxiolytic- but the hypnotic effects make them impractical for that use, except for those with really high tolerances.

Their widespread use seems poorly thought out. For most people, something like valium would knock them out just as well, and for people who have serious sleeping problems, starting off on a course powerful hypnotics will render drugs that could have been just as effective (initially) completely ineffective.

What is it about zolpidem that makes it psychedelic-ish? Perhaps it's the absense of the fourth ring? Does it have any known 5HT2a affinity?
 
Zopiclone, zolpidem and zaleplon all bind selectively to the alpha-1 subtype of the GABA-a receptor, so yeah, the same binding site as benzodiazepines but more selective.

alpha-1 is associated with sedation and amnesia, while drugs selective for the alpha-2/3 subtypes are purely anxiolytic with little or no sedation. However as you note selective alpha-1 agonists seem to be anxiolytic as well.

Zopiclone and zolpidem both produce "psychedelic" effects, but personally I found zolpidem much milder, just some LSD-like patterning, fractals etc, while zopiclone actually produced hallucinations, seeing people that aren't there etc. Never tried zaleplon, be interesting to compare them.

The hallucinogenic effects seem to be GABA-a related as none of these drugs have any affinity for 5HT2A. Note that some other GABA-a agonists are also hallucinogenic, muscimol being the classic example but some people report psychedelic effects from some benzos like lorazepam and nimetazepam also.

No idea why some GABA-a agonists produce this effect while others don't, especially as many benzos actually markedly reduce the visual effects from 5HT2A agonists. If it was purely an alpha-1 subtype mediated effect you might expect that any benzo that produces strong amnesia should also produce visual effects, but nimetazepam doesn't produce much amnesia yet is one of the benzos most commonly associated with visual effects, and clonazepam which does produce amnesia, is one of the benzos that kill LSD visuals quite effectively, so there must be something else to it.
 
Zopiclone does look like a good creative chemical structure. It has a sort of twisted elegance about it. I think with drug design it's sorta half art and half science.
 
I know I've said this before, but zolpidem has been more effective at effects classically associated with benzos (anxiolysis, muscle relaxation) than any benzos I have ever used. I also find it to be initially very euphoric; almost like an opiate. The blessing and curse of this drug that I've found is that the tolerance builds extremely quickly (1-2 days) to the point where you get nothing from it. But on the other hand after a week I drop to zero tolerance. I don't know why I seem to be the only one I know who's affected this way by zolpidem though.
 
^yeh I agree has thos effects on me also.....except further more it is stimulating. If im on the computer on BL or somin and pop like 15-20mgs 10mins later get some warm light euphoria and a burst of energy and loss of anxiety completely. IL get up and do some weights even and the other day I had some and was just planning on veging next thing I know I went for a 7km jog like wtf

but if i take it b4 sleep and put my head down im out like a light also kinda weird but I love it
 
I'm imagining the taste of a smokable zopiclone and it is the most revolting thing I can think of!

I find Zolpidem very psychadelic (visually in a way similar to LSD, mentally closer to diphenhydramine, but without the horrible depression). I'd reallllllllllly like to understand the psychadelic action much further. Then we could start talking about ways to modulate that action. I didn't find zopiclone to be psychadelic at all and that undefeatable metal taste put me off ever trying it again.

I'd list this substance in my top three.
 
That's about how I feel about zopiclone (though I never was really bothered by the metal taste, never too strong).

There are other drugs that interact with the same site as zolpidem but don't create the visuals. Could it perhaps cause some sort of downstream 5ht2a activation? Most everyone who had experience with both LSD and Zolpidem have described the visuals as being very similar.

Perhaps the key to understanding psychedelic visuals is reconciling the apparent contradiction of a highly selective GABA agonist producing 5HT2a-agonist like visuals. How could two drugs with such vastly different affinities produce similar visuals?
 
Nah I expect the effects are mediated by GABA-type receptors, rather than anything 5-HT2A related - but the particular conformation it may cause it to adopt might have certain effects, like how it works at 5-HT2A - or maybe it only acts at a certain location in the brain (like how 5-HT2A agonists mostly act at level V), which has tasks to do with visual processing - since GABA is all about inhibitory behavior, maybe this has something to do with it?
 
^An interesting thought. I've only tried this stuff a few times, and that was about 12-13 years back. It just felt like the bad parts of benzos without the muscle relaxation or any of the good stuff.
So, people actually 'tip' of this stuff? If it really does produce LSD type visuals then it could be an interesting path to follow. If it can be modified to NOT make you sleepby but make you trip... well, whole new class. Having said which, we really need a lot more people to agree upon the fact that it does make people trip. Like, what % trip? How long, how strong, what do yo feel like afterwards?
 
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