Heard a friend say this to a stranger, from african origin, just as a joke we are not at all racist however it could be seen as an insult; when a cataclysmic event happens, which part of the world would be destroyed first, africa of course... I found this really funny and the guy took it well...
A local polititian said on tv, insulting his wife; 'behind every great man stands a woman, and behind her his wife'; and also 'pls take good care of my secretary, she takes good care of me when after a long, hard day at home I arrive at work ...
Some local (Dutch) insults I like are 'kanker weg' (get cancer) 'tyfuslijer' (someone suffering from typhus) 'verrekte kanker mongool (stretched cancer person with syndrome of down)...
As you can see over here ppl like swearing with diseases haha...