Overdose
Main article: Benzodiazepine overdose
Overdoses of alprazolam can be mild to severe depending on how much of the drug is taken and if any other depressants have been taken. Alprazolam is significantly more toxic in overdose having higher rates of fatalities compared to other benzodiazepines. A study in New Zealand found that alprazolam is almost 8 times more likely to result in death in overdose than other sedative hypnotics as a group, with higher rates of intensive-care unit admissions and mechanical ventilation. Combined overdose with tricyclic antidepressants, alcohol, or opiates, or overdoses of alprazolam in the elderly, significantly increases the likelihood for severe toxicity and possible fatality.[110] Alprazolam (Xanax) overdose reflect the central nervous system depression of the brain and may include one or more of the following symptoms:[34]
* Somnolence (sleepy state)
* Hypotension (low blood pressure)
* Hypoventilation (shallow breathing)
* Impaired motor functions
o Dizziness
o Impaired balance
o Muscle weakness
o Impaired or absent reflexes
* Fainting
* Coma
* Death
About 50% of the cases of death involving alprazolam were attributed to combined drug toxicity of alprazolam and another drug, most often cocaine and methadone. Only 1% of such deaths were attributed to alprazolam alone.[111][112]
Dont really wanna die tonight ya know