Benzos Xanax and Valium

[Binky7766]

Hi, I have a pretty strong tolerance to benzos. I've been taking Xanax for 19 years. I've tried others, but find this to be most useful for my anxiety. Recently, I was prescribed Valium to stop tremors of my extremities. And of course, my doctor rightly told me to please not mix them with the Xanax.

I took 35 mg one night and was surprised to see how long it took for my anxiety to go away, which I suppose is normal considering my benzo dependence. It did stop my tremors. I then went back to my Xanax.

About a week later, I took 35 mgs of Valium, slept horribly with nightmares and actually had increased anxiety. I decided that I don't care for the Valium at all. Maybe I took too many milligrams, but, I just don't want to take it at all.

The next night, wanting to just finally go back to my Xanax and never look back to the Valium, I read online warnings against it. However, I took my regular Xanax dose (no Valium). I wasn't expecting anything since it was 24 hours after the Valium, but WOW, I have never felt so cool, calm and collected in my entire life. I was just digging it and could go with the flow with just about anything. Now, of course, I want to feel that again. I was wondering if maybe I take a smaller dose of Valium this evening and then tomorrow evening take my regular Xanax again, to see if that feeling returns. Or maybe a small dose of Valium and a small dose of Xanax together? I know, always trying to get that first high back. Classic.

I wondered if anyone had ever combined the two or had taken it 24 hours apart and had a reaction to it, or know of anyone who had a reaction to it, good or bad. But please, only responses that pertain to just Valium and Xanax combo. Cause it really sucks to be anxious already & you go to look at someone's reply hoping to get help and it just says "I don't know". Or, a different scenario/drug altogether. Bummer! Thank in you guys in advance!

 

[Deleted member 290563]

Valium has several active metabolites that stay in your system for a very long time after (days) and has a different and imo more pleasant high the next day rather than the day of dosing. The high the day of dosing is more disinhibition and sedation. The day after is a smooth clean energy and pep in your step feeling.

Also 10 mg valium is equivalent to 0.5 mg Xanax.

Do you maybe just not have enough Valium when you took it instead of the Xanax and maybe that’s why you felt bad (you were basically withdrawing?)

I don’t see what the problem would be mixing them as long as your mower the doses accordingly. Your doctor sounds kinda clueless is he a specialist?

 

[pcplease]

Your doctor sounds kinda clueless is he a specialist?

If the doc realizes that the tremors are due to being Rx'd alprazolam for 19yrs again, knows that the max dose of diazepam should ideally prevent almost anyone from "needing" Xanax in a true panic attack, i assume not wanting OP to take them together is because Dr knows combining the two will lead to even greater tolerance thus physical dependence

here in the US valiums rare anymore period, but I have only ever heard of clonazepam and alprazolam/lorazepam prescribed together in rare instances, alpraz/lorazepam in small amounts PRN and clonazepam as the daily med

0.5-1mg alprazolam = 10mg diazepam


Diazepams lengthy duration/afterglow is impressive. Japan in particular has seemingly started treated anxiety/insomnia with longer benzos than diazepam, so that a couple weeks treatment will linger in ones system's for months like librium. Mexazolam (main metabolite delorazepam and then lorazepam), Rilmazafone, Flutazolam and Flutoprazepam (both have the main active metabolite norflurazepam)

 

[Dextro .45]

Alprazolam (Xanax) is the most abused benzodiazepine in the US. Why? Because compared to Lorazepam (in a medical journal study) and other Benzo’s, Alprazolam cause the release/increase of Dopamine in the brains reward centre, and due to its Triazolo ring it appears to possess antidepressant properties

So Xanax is a rapid acting anxiolytic & antidepressant, which also causes a significant increase in dopamine in the CNS. Oxycodone, Xanax, and Ritalin (Methylphenidate) would be the ultimate euphoric oral speedball

Diazepam is also a super effective anxiolytic with robust muscle relaxant properties

Valium (Diazepam) & Xanax (Alprazolam) are the two most highly desirable benzodiazepines, often taken together.

Example Valium 20-30mg + Xanax 1mg for a 200 lbs plus adult (alone or better, added to take the edge off or make more pleasant a moderate amphetamine dose, Ritalin 20mg IR / Dexedrine 10mg IR / Adderall 10mg IR) add an Oxy-IR 5mg and it would be the most effective mood-boosting euphoric pro-social medicine to take before a large social gathering

….and yes, Diazepam has 3 active metabolites 200h half life with long term daily use as accumulation occurs of these long lasting metabolites

Alprazolam is also rapid acting like Diazepam but is rapidly cleared and has no active metabolites, so it hits fast and is rapidly metabolized & clearance from your system in your body

 

[Gridlink]

I'd try again OP. Take the valium in the evening, and then the next evening take the Xanax. As others have said in this thread, valium has long-acring metabolites that are probably interacting with the Xanax.

That is weird you got panic attacks and insomnia from the valium though. Those sound like symptoms of benzo withdrawal, but you were still feeling the effects of the valium, right?

 

[pcplease]

Alprazolam (Xanax) is the most abused benzodiazepine in the US. Why? Because compared to Lorazepam (in a medical journal study) and other Benzo’s, Alprazolam cause the release/increase of Dopamine in the brains reward centre, and due to its Triazolo ring it appears to possess antidepressant properties

So Xanax is a rapid acting anxiolytic & antidepressant, which also causes a significant increase in dopamine in the CNS. Oxycodone, Xanax, and Ritalin (Methylphenidate) would be the ultimate euphoric oral speedball

Diazepam is also a super effective anxiolytic with robust muscle relaxant properties

Valium (Diazepam) & Xanax (Alprazolam) are the two most highly desirable benzodiazepines, often taken together.

Example Valium 20-30mg + Xanax 1mg for a 200 lbs plus adult (alone or better, added to take the edge off or make more pleasant a moderate amphetamine dose, Ritalin 20mg IR / Dexedrine 10mg IR / Adderall 10mg IR) add an Oxy-IR 5mg and it would be the most effective mood-boosting euphoric pro-social medicine to take before a large social gathering

….and yes, Diazepam has 3 active metabolites 200h half life with long term daily use as accumulation occurs of these long lasting metabolites

Alprazolam is also rapid acting like Diazepam but is rapidly cleared and has no active metabolites, so it hits fast and is rapidly metabolized & clearance from your system in your body

alpraz does have a couple active metabolites

diazepam has shown to have a significant antidepressant effect as well.

 

[pcplease]

I'd try again OP. Take the valium in the evening, and then the next evening take the Xanax. As others have said in this thread, valium has long-acring metabolites that are probably interacting with the Xanax.

That is weird you got panic attacks and insomnia from the valium though. Those sound like symptoms of benzo withdrawal, but you were still feeling the effects of the valium, right?

the sort of panic attack one can get on a benzo. as for the insomnia, valium is such a strong anticonvulsant and alpraz so weak that the tremors and physical effects of alpraz dependence being wiped away could have caused a strong change in your sleep pattern, all the stages, and nightmares arent uncommon. plus while maybe equivalent per dose, alpraz does more damage/downregulation and switching to the arguable best taper benzo might not be super painless. Cakewalk compared to without it, im sure.

for the most part, i have a hard time falling asleep if i feel much effect still active after the 6-12hr window, including (if not especially) heavy hypnotics like flubrotizolam.

 

[Psynaught]

Valium has several active metabolites that stay in your system for a very long time after (days) and has a different and imo more pleasant high the next day rather than the day of dosing. The high the day of dosing is more disinhibition and sedation. The day after is a smooth clean energy and pep in your step feeling.

Also 10 mg valium is equivalent to 0.5 mg Xanax.

Do you maybe just not have enough Valium when you took it instead of the Xanax and maybe that’s why you felt bad (you were basically withdrawing?)

I don’t see what the problem would be mixing them as long as your mower the doses accordingly. Your doctor sounds kinda clueless is he a specialist?

10 milligrams of Valium hits me like 2 mg of Xanax.

 

[Dextro .45]

Enter Diazepam 2.0 ….. Avizafone (Pro-Diazepam)

A water soluable, rapid acting, pro-drug that once is administered via IM injection has a rapid onset of 10-15min which Avizafone molecule has been cleaved into l-Lysine & Diazepam (Valium)

Administration of Avizafone (Pro-Diazepam) has an impressive T-Max of 0.5 - 0.7h max as compared to 1.5h for oral Diazepam….and C-Max for Avizafone is significantly higher than oral Diazepam too

It’s basically Super Valium lol ……I’ve probably went through 10 to 12 orders already of 1,000mg over several years

Avizafone 22.5mg IM is equivalent to Valium 10mg

 

[Binky7766]

10 milligrams of Valium hits me like 2 mg of Xanax.

Not me, I need 30 mgs of Valium to get an effect even close to two .50 Xanax.

 

[Dextro .45]

alpraz does have a couple active metabolites

diazepam has shown to have a significant antidepressant effect as well.

Alprazolam and other triazolobenzodiazepines such as triazolam that have a triazole ring fused to their diazepine ring appear to have antidepressant properties. This is perhaps due to the similarities shared with tricyclic antidepressants, as they have two benzene rings fused to a diazepine ring. Alprazolam causes a marked suppression of the hypothalamic–pituitary–adrenal axis. The therapeutic properties of alprazolam are similar to other benzodiazepines and include anxiolytic, anticonvulsant, muscle relaxant, hypnotic,

Giving alprazolam, as compared to lorazepam, has been demonstrated to elicit a statistically significant increase in extracellular dopamine D1 and D2 concentrations in the striatum.

Alprazolam is metabolized in the liver, mostly by the cytochrome enzyme CYP3A4. Two major metabolites are produced: 4-hydroxyalprazolam and α-hydroxyalprazolam, as well as an inactive benzophenone. The low concentrations and low potencies of 4-hydroxyalprazolam and α-hydroxyalprazolam indicate that they have little to no contribution to the effects of alprazolam

___________________________


But ya, feeling horrific then taking 3-4 Valiums would definitely feel amazingly antidepressant like in 30min when you’re melting into relaxation bliss ….Id add a 1mg Xanax to the mix for the anxiolytic dopamine + true antidepressant mix.

Even Tramadol is an opioid + SERT/NET reuptake inhibitor…..Demoral IV is like a Speedball. A true Mu-Opioid agonist + a similar MOA to a Tropaine Alkaloid (being a DAT reuptake inhibitor & increasing monoamines)

Sooooo…….Alprazolam is Alprazolam. It’s 2 “active metabolites” are so piss poor weak, they contribute Fck all to the effects of Alprazolams rapid acting, fast clearance…..unlike Diazepam 3 active long acting metabolites

And Diazepam effects don’t have antidepressant effects like Alprazolam does……Diazepam is a2 & a3 are robust anxiolytic that may feel like antidepressant, but they’re anxiolytic….plus muscle relaxant properties……where as Alprazolam features a Triazolo ring as stated above …..

 

[notsmokeymcpot42088]

10 milligrams of Valium hits me like 2 mg of Xanax.

Someday I propose a very hypothetical trade lol im sure you got someone closer than me that would take ya up on that ratio! (Dont trade your prescriptions its illegal and whatnot)

I am with dextro in the fact during my vast benzo research I have found the triazolam ring to be pretty linked to euphoria. Clonazepam my go to script benzo clonazolam the go to 'recreational' benzo.

I doubt OP has access to avisafone or clonazolam though --- idk being scripted two benzos seperately is pretty fortunate, youll figure it out. Xanax would be my rec and valium would be my stable if I were you (But this is all subjective to a point)

I could prolly get switched to something else at equivalent doses but not worth the hassle and the being looked at twice I figure.

 

[Mudflapper]

I went through benzo withdrawal and it was hell on Earth. Finally found a new doc that got me off multiple-dose-per-day benzos. He switched me to Valium to help me taper and it took 10 long months. It has a much longer half life so it's very steady compared to Xanax which was up and down for me, but it still sucked. Thought I was going out of my mind, thought it was going to be the new normal until the day I died. While tapering he put me on Remeron, Mirtazpaine is the generic, which was introduced back in 1997 and when I started it in 2000 it was still very new and expensive. It is used much more in the EU, especially for withdrawal. It doesn't get you high. It's not addictive. It just removes anxiety from the equation and give you the best sleep you've never had in your life. No sexual side effects either. For many, you might get weight gain, and tiredness at least until your dosage is upped to 30 or 45mg a day. The lower the dosage the more it knocks you out.

 

[notsmokeymcpot42088]

Remeron hey, that rings bells......if I remember ppl bitching about it bells. (prolly cuz they preferred they benzos but idk)

If it can get you through benzo w/d it is something worth discussing!

 

[Binky7766]

I'd try again OP. Take the valium in the evening, and then the next evening take the Xanax. As others have said in this thread, valium has long-acring metabolites that are probably interacting with the Xanax.

That is weird you got panic attacks and insomnia from the valium though. Those sound like symptoms of benzo withdrawal, but you were still feeling the effects of the valium, right?

Sorry, major delay time here (aka a year)! I stopped getting panic attacks from the diazepam. Perhaps my system adjusted! I'm able to take 30 mgs with no problem now, which really does make sense because I take a milligram of Xanax daily, so I should be able to handle the Diaz. and I haven't been taking the Diaz right before bed, which I think might be key. I've taken Xanax at night and then Diaz the next day and still cannot recapture that groovy feeling. I'm thinking it must be a timing thing. One day, I mixed a very small amount of the Xanax with a very small amount of the dias to see what, if anything would happen nothing did other than I slept pretty darn well that night. Wondering if I take my usual Xanax dose during the day about an hour after I take the dias, what that would feel like. The only problem is that the Xanax makes me so sleepy and with the Diaz, I'd probably be comatose on the couch all day and I don't want to waste a perfectly good Sunday.

I've tried doing what you suggested by taking Xanax one night and die the next night, but that hasn't given me the feeling that I initially experienced, not even close. Not sure why! The only thing I can think of would be to increase the doses slightly. I have a very high tolerance.

 

[Binky7766]

Valium has several active metabolites that stay in your system for a very long time after (days) and has a different and imo more pleasant high the next day rather than the day of dosing. The high the day of dosing is more disinhibition and sedation. The day after is a smooth clean energy and pep in your step feeling.

Also 10 mg valium is equivalent to 0.5 mg Xanax.

Do you maybe just not have enough Valium when you took it instead of the Xanax and maybe that’s why you felt bad (you were basically withdrawing?)

I don’t see what the problem would be mixing them as long as your mower the doses accordingly. Your doctor sounds kinda clueless is he a specialist?

Hey, i'm just getting to all of these responses to everyone a year after the fact. To answer your question, my doctor is my primary.
The Xanax and diazepam doses that I have been taking our equivalent of each other, as you indicated above, I was careful of that. As I was telling one of the other posters, who replied to me, I have never been able to get that groovy kind of feeling back no matter what I try as far of order of things and doses. I feel like maybe it's a dosage thing. Maybe if I took them at the same time or taking the Xanax after the diazepam has had enough time to kick in, maybe an hour or so.

 

[Binky7766]

I'd try again OP. Take the valium in the evening, and then the next evening take the Xanax. As others have said in this thread, valium has long-acring metabolites that are probably interacting with the Xanax.

That is weird you got panic attacks and insomnia from the valium though. Those sound like symptoms of benzo withdrawal, but you were still feeling the effects of the valium, right?

Yeah I've tried the Valium one night & the Xanax the next. Nothing. My body has adjusted to the doses though, so thinking maybe increasing just a little bit to see if anything happens. If not, then just forget the whole thing.

That particular night of the panic attacks and nightmares,I don't remember if I was feeling the effects of the Valium. Maybe I took it too late, I just don't know. But I've since adjusted to the dose and have not had that type of reaction again. My Xanax dose is the equivalent of the Valium dose and nothing I've tried as far as timing goes has brought back that easy breezy type of feeling.

 

[BadBoy377]

Yep, I take them both on the same day for various reasons sometimes. It's ok. Won't kill you, probably just fall asleep.

Diazepam probably superior overall. Alprazolam hits harder, faster then wears off. Diazepam smooth up and down more preferable imho.

 

[notsmokeymcpot42088]

remeron is an antidepressant not a benzo

I typed in 'remeron for benzo w/d' and the first result on google was the suicide hotline lmao --- please do tell us more about how remeron can get us off benzos @Mudflapper

Damn me listening to greenlighters (just breakin balls mudflapper no real issue!)