Stimulants Would Vraylar weaken vyvanse?

[xbandit07x]

I havent taken vyvanse or Dexedrine in a long time, but I used to be on a lot and whenever I take a few months/year off 70 vyvanse works pretty nicely, strong enough.

I was prescribed 1.5 mg Vraylar and 70 vyvanse and took vyvanse in the morning on day 1, then at night Vraylar for the first time, thismorning on day 2 took 70 vyvanse and cant tell if it was changed or weaker by the addition of the other med.

It is hard for me to tell.

 

[mtu mwendawazimu]

I take vraylar, and have used meth while on vraylar. Might seem like a bit of a stretch, but meth and dextroamphetamine are similar IME.

I could still feel the effects of meth even when on vraylar, so if i were you i wouldn't dramatically increase your amphetamine dose too high to counteract it.

 

[xbandit07x]

Do certain drugs of this class counteract stimulants more? That is what I was wondering. Yeah I know this is a more subtle one.

May not block/reduce any of the receptors affiliated with d amp/ d meth.

 

[mtu mwendawazimu]

I did meth before and after vraylar, and felt no noticeable difference. Maybe it would be good to hear from someone who did research, though.

@sekio - do you know??

 

[sekio]

I think methamphetamine would easily cut through the effects of cariprazine. It looks like it's mostly a D₂ and D₃ partial agonist, and as I understand things the D₁ and D₅ receptors are more responsible for the reinforcing amphetamine-type effects caused by DA release.

 

[xbandit07x]

I think methamphetamine would easily cut through the effects of cariprazine. It looks like it's mostly a D₂ and D₃ partial agonist, and as I understand things the D₁ and D₅ receptors are more responsible for the reinforcing amphetamine-type effects caused by DA release.

but do you think something like 70 vyvanse is too small of an amount to not be effected? I cant have my regular dextro amphetamine being blunted at all lol.

 

[sekio]

The only way to know for certain is to try it. Given how similar the pharmacology of meth and amphetamine is, I'd expect it would still work too.

 

[AlphaMethylPhenyl]

I think methamphetamine would easily cut through the effects of cariprazine. It looks like it's mostly a D₂ and D₃ partial agonist, and as I understand things the D₁ and D₅ receptors are more responsible for the reinforcing amphetamine-type effects caused by DA release.

This is interesting. Not to hijack, but what makes a substance affect affect the nigrostriatal tract vs the cortical/limibic? Like levodopa vs. amp?

Vraylar will likely reduce the crash, of which can be really hard, even if you're taking a stimulant like vyvanse.

Amp is a tricky bugger though. It can start as very powerful in a good respect, then a few months down the line just help concentrate if you want and more importantly could cause serious agitation and antisocial behavior.

 

[xbandit07x]

I am not taking it again, im really observant and saw that it actually nullified some of my Kratom effects.

I notice it made me want to do things on my vyvanse like start creating a videogame, rather than sit on a sedative feeling, which is really important for my add.

Yeah I used to take benzos a long time ago, never withdrew from them, and this may have blocked cravings for another amphetamine thats about it, but I really need every drop of d amp to work I can get, thats why I take long tolerance breaks just so 70 vyvanse works again, For me to take something like Vylar I would need 60-100 mg Dexedrine in a day.

I couldnt even take benzos in while in amp season without another 20-50 mg of them ontop of my 50-80 mg script.

Im really sensitive to downers of any kind making it a requirement to have to munch on more dexedrine I cant get ahold of. every bit of my 70 vyvanse is required lmfao. Like all four D1-4 receptors are needed.

 

[carsonigen]

I think methamphetamine would easily cut through the effects of cariprazine. It looks like it's mostly a D₂ and D₃ partial agonist, and as I understand things the D₁ and D₅ receptors are more responsible for the reinforcing amphetamine-type effects caused by DA release.

What do mean by "cut through"?
I'm planning on taking meth again and I can't go off my vraylar for personal reasons.