Would taking mescaline two days after taking acid reduce the effects?

[Aboy699]

I took two hits of acid and a Molly Thursday night and had a great trip. On Saturday my friend and I tried mescaline for the first time. I took one "hit" which was supposed to have 400 Mgs in it. We went to a bar for a few drinks and a few hours passed and we felt slightly different, but were not tripping. We each took another and walked In the park by the river.. It was noticeable at this point but a couple hours passed and we were basically back to normal..I'm pretty certain the stuff was legit cuz I got from a reliable source..Anyone know why this might have happened? Anyone know why this could have happened? I think it could have something to do with the acid I took two days earlier. I'd also been doing alot of Ketamine during that time. My friend was complaining the whole time how it wasnt working , maybe that negatively effected it somehow....Any thoughts??

 

[Jesusgreen]

From what I've heard, 400mg can be quite underwhelming. I'd be rather suspicious though when being sold Mescaline in powder form. Although it is around, it is rather rare, and it's much more common that you'll be ripped off or sold a related phenethylamine RC in it's place. The fact your friend noticed no effects the whole time suggests to me that there was something wrong with the product - either a bad synth that left it rather low quality meaning you'd need more, or something else, hard to speculate.

The fact is, taking acid 2 days before DEFINITELY had a massive effect on it. Both are 5ht2a agonists, so share cross-tolerance. I'd say to take at least 1.5x as much as a usual dose if you'd tripped 2 days before, and in some individuals this would be more like 2x as much. However if your friend took 800mg and felt nothing, I'd be more suspect about the quality/content of what you were given - unless your friend also tripped in the last day or two prior to that.

 

[LogicSoDeveloped]

To be honest, real mescaline is difficult to find as it isn't commercially sound. It takes a lot of cactus to extract a small amount of Mescaline and IME, when it is available, it is expensive. I am lucky to have a chemist friend though I have never come across someone selling any. I hear that a lot of fake "mescaline" is just sold as such because being so rare, it is bought up. I hate to tell you so but I am thinking the stuff you got is fake. I don't think a strong enough phenethylamine cross tolerance would be formed from the single MDMA use, Mescaline being a phenethylamine. I don't think the K would've played a part in this.

 

[any major dude]

Regarding tolerance, the LSD would have likely played a much larger role than the MDMA. Even though mescaline & MDMA are both phenethylamines, LSD & mescaline are much more similar pharmalogically and tolerance is dependent on the latter. Generally you should wait at least a work week between trips to negate physiological tolerance (longer with monamine releasers like MDMA et al), and honestly at a week for me, there's still some tolerance, but the length of time it takes tolerance to dissipate seems to vary quite a bit from person to person. It's generally regarded as wise to wait at least 2 weeks between trips in order to fully integrate the experience and what not.

 

[Ismene]

It's 99% certain it wasn't mescaline - it will just have been some research chemical.

 

[LogicSoDeveloped]

Regarding tolerance, the LSD would have likely played a much larger role than the MDMA. Even though mescaline & MDMA are both phenethylamines, LSD & mescaline are much more similar pharmalogically and tolerance is dependent on the latter. Generally you should wait at least a work week between trips to negate physiological tolerance (longer with monamine releasers like MDMA et al), and honestly at a week for me, there's still some tolerance, but the length of time it takes tolerance to dissipate seems to vary quite a bit from person to person. It's generally regarded as wise to wait at least 2 weeks between trips in order to fully integrate the experience and what not.

ah, good to know, thanks man

 

[skillet]

From what I've heard, 400mg can be quite underwhelming.

200mg (as the HCl salt) is mild but well above threshold. 800 would be a huge dose, and definitely not recommended for a first time! How did it look, OP? Was it a large amount of powder in a big gel-cap, or big, clear, needle-like crystals? Either way, it sounds like it either wasn't mescaline, or was a very small dose.

↓ 2-400mg of the sulfate, I guess all the doses given for the experience reports are for the sulfate too, it's not clear from the erowid version at least. But yeah, 400mg of either would be a pretty full-on dose.

 

[sekio]

The dose Shulgin reccomends is 200-400mg of the sulphat (or was it hydrochloride). 400mg would be a pretty hefty dose.

There's been a growing trend of people selling all osrts of other psychedelic drugs, esp. the 2c's, as "mescaline". Be careful and always do some tests on your compound.

 

[Pegasus]

It's 99% certain it wasn't mescaline - it will just have been some research chemical.

You can't say that with any degree of certainty. This person is in the USA... mescaline is around.

OP, 400mg is a decent dose, though I personally would prefer a bit more. Mescaline is one of the few psychedelics that I like very intense trips with since my train of thought doesn't get too confused at high doses.

There is definitely a cross-tolerance with LSD which probably didn't help.

 

[skillet]

Yeah but what about their friend, who (I guess) didn't take acid 2 days before, and at a supposed 800mg?

 

[Pegasus]

^I don't see that the other friend didn't take it. Anyway, it's all speculation... I'm just saying it is not at all unreasonable for someone to have mescaline. There are lots of RCs around nowadays, sure, but none quite like mescaline. It's not a huge leap IMO for someone to do a basic extraction on wild cacti to get such a coveted drug.

 

[skillet]

No, I agree with you, and, like I said, I don't know if the other friend took the acid with them. Could really use some more info from the OP to say anything.

 

[Aboy699]

My friend didn't take the acid two days beforehand. He rarely takes drugs these days,I think he did mushrooms like a month ago but that's all I think

 

[skillet]

Ok, how about the appearance? Did you open the caps and look at the stuff? Was there a lot (hundreds of mgs) or not much? Just thinking the amount of substance might tell you something (it would take a large, well stuffed gel cap to fit 400mg) and the appearance (mescaline sulfate crystallises as large needles, though it could have been the hydrochloride salt, which doesn't easily form large crystals, or a 2C cut with something to make it look like a large amount, which would also look more powdery.)

Whatever the case, you either didn't get mescaline, or you did, but not in the dose promised.

 

[Aboy699]

It wasn't crystally at all..it was really powdery and it was in a decent sized capsule. It was completely filled to the top. I didn't take it out to look at it but ive got two more so I'll be sure to inspect closely when I get home. The dude who gave me them has sold me shrooms, LSD, Ketamine. All that was legit so it would surprise me if he burned me this time..

 

[JackHaveNot]

Mescaline at 400 mg is probably not going to be overwhelming for someone who used to LSD but they will certainly be noticeably high for more than a few hours. I'd expect a hour of transition, 3 or 4 hours of pretty good tripping (although not anywhere near losing your head like acid) and about 4 hours of a nice roll, almost like real clean mdma but with a definite psychedelic tinge.

It's entirely possible that you got extracted "mescaline" that was either the product of a faulty extraction or the underlying raw cactus was weak. Such a screw up will often give up a lot of dirty table salt, which can be mistaken for mescaline if it's not cleaned & tested.