Would pregabalin become a street drug?

[Jamshyd]

Hmm... I'm hesitant to post this for many reasons. Mods, feel free to lock/delete - I woulc completely understand.

But anyways, the structure of pregabalin (3-isobutyl GABA) is very simple. What I am wondering is whether its synthesis is easy or not?

I am not asking for synth recipes. I am simply asking people here with chemical knowledge if such a compound is easy enough to synthesize by underground chemists that soon it would become a street drug, since more and more people (at least on BL) seem to be reporting it to be comparable to GHB and MDMA.

 

[fastandbulbous]

Very simple to synth from fairly simple starting materials (it's basically an unnatural amino acid).

There are a few amino acids that share the NH2CH2-C-C-COOH (where the two 'middle' carbon atoms have a variety of things done to them) that seem to be good replacements for GHB (from the above pregabalin to TACA - trans aminocrotonic acid NH2CH2CH=CHCOOH ) that are very active analogues, it just seems to be a case of looking for them; all pretyy simple to synthesise as well.

 

[BilZ0r]

Well more the problem is most people don't think it would be any fun at all.

 

[jasoncrest]

Well more the problem is most people don't think it would be any fun at all.

Yes exactly.
And even in its pharmaceutical form, it won't be a drug of abuse.
I've tried Lyrica (pregabalin) many times, and I have also tried Gabitril (tiagabine) many times.
Both feel EXACTLY the same, yet Gabitril has been marketed for many many years (maybe 10), and theres is no abuse use of Gabitril....


And see the posts about Baclofen: everyone says it's like GHB, but it is not abused either....

For all these reasons (even if Lyrica, Gabitril, Baclofen... feels like GHB according to many posts in BL), I don't think they will become drugs of abuse. (and they won't become street drugs either)

 

[yaesutom]

I've got some experience with Baclofen...

I had wanted to taste some for a while now etc etc, man.. ! it was EXCELLENT..

The euphoria of GHB isn't 'there', but, i felt just as loose and giggly free as i would on GHB. But... it seems like the tolerance *skyrockets* up so high so fast, i mean to where it just does not work anymore - at all, and now even after weeks of not using it i'll take a big ass dose of baclofen and it still doesn't do shit.

When I first tried some gabapentin, it was the same way.. i REALLY liked it at a good dose, but even at regular/lower doses, ... worked totally good, anxiety, yada yada, like a lot of the 'theraputic' effects of GHB were there..

But that pooped out on me the same way, a year later i eat 900mg gabapentin and it just does not do anything anymore.. wierd..

 

[~_Hiss_~]

i havent gotten tolerance to neurontin after being on it almost 4 years now (although I can withdrawal-not pleasent). I was once up to 3200mg a day and slowly moved down to 900mg a day and I didn't feel much different. Sometimes I feel a high from 300mg and sometimes i barely feel it; but 600mg I always feel. Sometimes it feels good, sometimes it doesn't. I think it doesn't just depend on individual brain chemistry to enjoy these kind of drugs, but it could depend on the time of day, mood, when your last orgasm was, if you worked, your hydration level; all these things can interact with my gabapentin buzz.

I also noticed that when I smoke weed, after the high wears off, for up to a day or so I can barely even feel my neurontin. I've confirmed this to be true plenty of times... why do you think this is? Also opiates tend to increase the effect and make me require less, but once the opiate wears off, my neurontin is less effective and I feel that anxious empty feeling that means I need more neurontin, when in fact i took a normal dose as usual. Strange.

 

[jasoncrest]

I've got some experience with Baclofen...

I had wanted to taste some for a while now etc etc, man.. ! it was EXCELLENT..

The euphoria of GHB isn't 'there', but, i felt just as loose and giggly free as i would on GHB. But... it seems like the tolerance *skyrockets* up so high so fast, i mean to where it just does not work anymore - at all, and now even after weeks of not using it i'll take a big ass dose of baclofen and it still doesn't do shit.

When I first tried some gabapentin, it was the same way.. i REALLY liked it at a good dose, but even at regular/lower doses, ... worked totally good, anxiety, yada yada, like a lot of the 'theraputic' effects of GHB were there..

But that pooped out on me the same way, a year later i eat 900mg gabapentin and it just does not do anything anymore.. wierd..

I just tried 20mg Baclofen for the first time. I didn't felt anything...

When I tried 15mg Tiagabine or 900mg Pregabalin (Lyrica) the first times it got me really high (GABAergic effects).

 

[blase deviant]

IIRC, the dose to get high off baclofen is like 90-100mg plus, I think I read somewhere 180mg. But don't do this, because I'm a dumbass, and there's a 99.9% chance I'm wrong.

And the consensus is that baclofen feels like GHB without as much euphoria? Has anyone tried mixing balcofen with alcohol or soma or benzos?

 

[edarrin]

Also opiates tend to increase the effect and make me require less, but once the opiate wears off, my neurontin is less effective and I feel that anxious empty feeling that means I need more neurontin, when in fact i took a normal dose as usual. Strange

Yeah, I have noticed this as well. it goes really nicely with opiates for a while then I become irritable for some reason. A bit of valium usually fixes it right up though.

I like it overall though. Seems to work on a different neuronal system. Now I can render another pathway in the CNS dysfunctioal. Wonder what the 'withdrawl syndrome' is like.

 

[DexterMeth]

well due to someone telling me how bomb baclofen "is" is just bought some...i expect it in a couple weeks, and hope i didnt throw my $ down the toilet.
I only bought like $50 worth, which is actually quite a lot of it, but shit...if it sucks, that 50 could of gone towards a hippy flip.
I'm doing a REAL andd NATURAL ayahuasca trip in a couple of days thoughm si naybe i just won't care..or maybe i will give up all drugs, including methadone forever...who knows.

i seriously doubt it will stop me from taking methadone though..but im almost completely cetain that that i will experience one of the most profound mind opening/soul clensing psychedelic trips experienced....
wish me luck!
laterz all.

 

[bingey]

I just tried 20mg Baclofen for the first time. I didn't felt anything...

When I tried 15mg Tiagabine or 900mg Pregabalin (Lyrica) the first times it got me really high (GABAergic effects).

jcrest i bet you got a nice tolerance to that decontractyl stuff (forgot the chemical)

i can imagine there is significant cross tolerance

 

[Dr. Beat]

well due to someone telling me how bomb baclofen "is" is just bought some...i expect it in a couple weeks, and hope i didnt throw my $ down the toilet.
I only bought like $50 worth, which is actually quite a lot of it, but shit...if it sucks, that 50 could of gone towards a hippy flip.
I'm doing a REAL andd NATURAL ayahuasca trip in a couple of days thoughm si naybe i just won't care..or maybe i will give up all drugs, including methadone forever...who knows.

i seriously doubt it will stop me from taking methadone though..but im almost completely cetain that that i will experience one of the most profound mind opening/soul clensing psychedelic trips experienced....
wish me luck!
laterz all.

if you are high on methadone (or any opiate for that matter), and then take baclofen, it will totally take away the methadone (opiate) high - i have tried it once, and will never do that ever again.

only good if you are TOO HIGH on opiates, and want to 'come down' (very unlikely!)

 

[BilZ0r]

^ In no way take this as a suggestion that baclofen should be taken as an antidote to opiate overdose, as baclofen should worsen respitory depression induced by opiates.

 

[lostNfound]

And the consensus is that baclofen feels like GHB without as much euphoria? Has anyone tried mixing balcofen with alcohol or soma or benzos?

Ive played around with this quite abit.
most ive ever had was 140 mg after about 1-12 standard drinks. I find it doesnt do much at all. Alcohol or no alcohol.

Its always the next morning, for the first hour or two after waking up I feel like im on G but different.
Its a really speedy feeling, where I actually feel abit razy nuts in a manic (yet controlled) way.
Its like a comedown from no other drug ive ever had, always a very weird but fun experience.

 

[jasoncrest]

if you are high on methadone (or any opiate for that matter), and then take baclofen, it will totally take away the methadone (opiate) high

Sorry to go Off-Topic, but why does Baclofen kills the high of Methadone??

 

[Dr. Beat]

Sorry to go Off-Topic, but why does Baclofen kills the high of Methadone??

a simply explaination is that normally Dopamine neurons are slowed down by GABA neurons that are surrounding them. The GABA reurons constantly release GABA that 'hits' GABA-B' receptors on dopamine neurons to slow down the firing rate of dopamine neurons.

There are lots of Mu-opiate receptors on these GABA neurons, and when activated by an opaite, slow down the GABA neurons, so they relasese less GABA, so the Dopamine neurons then fire faster.

So when you take baclofen, a GABA B receptor agonist, it tells the dopamine neurons to slow down.

This explains alot more:

http://alcalc.oxfordjournals.org/cgi/reprint/37/5/485

 

[BilZ0r]

^ Yeah, maybe that would be an explanation why baclofen would stop animals self-administering opiods, but not all of opioids effects are mediated by dopamine are they?

 

[SoupMane]

i figure it would be gtood for me to chime in - firstly every morning i do take 2400mgs of gapanentin (neurontin) which i believe definately potenates the pregabalin (lyrica) but i also will take only 75mgs in the morning, then later at night...(dosage will be uped soonk..) andi defiantely feel odd but now that i have acclimated, enjoyable effects....

it does not act directly onj your gaba or opiate receptors, and really im not quite sure how it workws (specally with the neurontin) but it does FEEL opiate like to me, at first i experienced slight stomache-uncomfortableness...

my pupules became small... i usually feel a rush of happiness a mood pusyh if you will and then i feel kind of 'smacky'...i hate to use that word but i really dont know how tok describe it otherwise... anyway awt first honestly it was an uncomfortable feeling but now i almost crave it....

it seems also that whatever direction i wish to take the high in i can do so... ei...i take ampetamines and it potenates it ... take benzos and it DEFIANTGELYI potentantes it... sorry i need to leawve quick, will lpost more later...

 

[MolokoVelocet]

neutontin + pregabalin combo? fascinating. what about gabitril? recently had both in supply building up to pregabalin w/ psych but ate'em all up. gabitril fizzled out on me within a few days of starting it and neurontin only worked the first time i took it.

i take 300mg pregabalin 2x a day and i love it.

Fellow Lyrica/pregabalin lovers ive got something ive found to be almost too good to be true in combo w/ lyrica....

Gotu Kola. Ive been heavily into herbs/suppliments/etc for half a decade and Gotu Kola is hands down the coolest ive fucked with.

Gotu Kola + Pregabalin strongly potentiate eachother (each alone is an awsome feeling) into an almost constant all day opiate euphoria /w GHB and other unidentifiable aspects. Great for motivation, strange enough.
The closest thing I can think of to the feeling is methadone + klonapin (more like xr xanax than klonapin actually). EXTREMELY remeniscent of the feeling i get on methadone 10-15mg without the tolerance issues and the other annoying side effects of methadone.

Gotu Kola alone is actually very similair to Lyrica is numorous ways. Both are as effective as benzo's for my anxiety and both are miracle drugs as far as im concerned regarding depression.

 

[lashes]

well due to someone telling me how bomb baclofen "is" is just bought some...i expect it in a couple weeks, and hope i didnt throw my $ down the toilet.
I only bought like $50 worth, which is actually quite a lot of it, but shit...if it sucks, that 50 could of gone towards a hippy flip.
I'm doing a REAL andd NATURAL ayahuasca trip in a couple of days thoughm si naybe i just won't care..or maybe i will give up all drugs, including methadone forever...who knows.

i seriously doubt it will stop me from taking methadone though..but im almost completely cetain that that i will experience one of the most profound mind opening/soul clensing psychedelic trips experienced....
wish me luck!
laterz all.

why would u think it would stop u from takin g methadone? are u on a daily dose of methadone, if so who told u that might work?