red22
Bluelighter
- Joined
- Nov 23, 2009
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DMT is not orally active but is metabolized by the stomach enzyme monoamine oxidase (MAO). Certain chemicals in the vine inhibit the action of MAO and are therefore referred to as MAO-inhibitors: their presence in the brew makes the psychoactive principle available and allows it to circulate through the bloodstream into the brain, where it triggers the visionary access to otherworldly realms and beings.
Ayahausca: Sacred Vine of the Spirits. Ralph Metzner (editor), 2005, Introduction
The following statement incited this question:
Another advantage is that the drug does not go through the digestive system. This means the drug is not metabolized through the liver, and thus a lower dose can be used.
http://www.healthline.com/health/sublingual-and-buccal-medication-administration
It notes that the article was "Medically Reviewed on June 14, 2013 by George Krucik, MD, MBA"
Another question I have is do you think that high doses of selegiline are sufficient to use for ayahuasca, which requires an MAO-A inhibitor?
All of the studies below can be downloaded here.
High doses, e.g., 10 mg/kg, of selegiline are reported to inhibit partially MAO-A activity as assessed by an inhibition of the deamination of the preferred MAO-A substrate, 5-HT (Green et al., 1977; Demarest et al., 1980)
Green AR, Mitchell BD, Tordoff AF, Youdim MB. 1977. Evidence for dopamine deamination by both type A and type B monoamine oxidase in rat brain in vivo and for the degree of inhibition of enzyme necessary for increased functional activity of dopamine and 5-hydroxytryptamine. Br J Pharmacol. Jul 1977; 60(3): 343–349
Demarest KT, Smith DJ, Azzaro AJ. 1980. The presence of the type A form of monoamine oxidase within nigrostriatal dopamine-containing neurons. J Pharmacol Exp Ther. 1980 Nov;215(2):461-8.
Butcher SP, Fairbrother IS, Kelly JS, Arbuthnott GW, 1990, Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum. Journal of Neurochemistry, Vol. 55, No. 3, 981-988
MAOI research for the harmine found in traditional ayahuasca brews:
Udenfriend S, Witkop B, Redfield B, Weissbach H. 1958. Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds. Biochemical Pharmacology, 1(2):160-165. DOI:10.1016/0006-2952(58)90025-X
Buckholtz NS, Boggan WO. 1977. Monoamine oxidase inhibition in brain and liver produced by beta-carbolines: structure-activity relationships and substrate specificity. Biochemical Pharmacology, 26(21):1991-6. DOI:10.1016/0006-2952(77)90007-7
Ayahausca: Sacred Vine of the Spirits. Ralph Metzner (editor), 2005, Introduction
The following statement incited this question:
Another advantage is that the drug does not go through the digestive system. This means the drug is not metabolized through the liver, and thus a lower dose can be used.
http://www.healthline.com/health/sublingual-and-buccal-medication-administration
It notes that the article was "Medically Reviewed on June 14, 2013 by George Krucik, MD, MBA"
Another question I have is do you think that high doses of selegiline are sufficient to use for ayahuasca, which requires an MAO-A inhibitor?
All of the studies below can be downloaded here.
High doses, e.g., 10 mg/kg, of selegiline are reported to inhibit partially MAO-A activity as assessed by an inhibition of the deamination of the preferred MAO-A substrate, 5-HT (Green et al., 1977; Demarest et al., 1980)
Green AR, Mitchell BD, Tordoff AF, Youdim MB. 1977. Evidence for dopamine deamination by both type A and type B monoamine oxidase in rat brain in vivo and for the degree of inhibition of enzyme necessary for increased functional activity of dopamine and 5-hydroxytryptamine. Br J Pharmacol. Jul 1977; 60(3): 343–349
Demarest KT, Smith DJ, Azzaro AJ. 1980. The presence of the type A form of monoamine oxidase within nigrostriatal dopamine-containing neurons. J Pharmacol Exp Ther. 1980 Nov;215(2):461-8.
Butcher SP, Fairbrother IS, Kelly JS, Arbuthnott GW, 1990, Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum. Journal of Neurochemistry, Vol. 55, No. 3, 981-988
MAOI research for the harmine found in traditional ayahuasca brews:
Udenfriend S, Witkop B, Redfield B, Weissbach H. 1958. Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds. Biochemical Pharmacology, 1(2):160-165. DOI:10.1016/0006-2952(58)90025-X
Buckholtz NS, Boggan WO. 1977. Monoamine oxidase inhibition in brain and liver produced by beta-carbolines: structure-activity relationships and substrate specificity. Biochemical Pharmacology, 26(21):1991-6. DOI:10.1016/0006-2952(77)90007-7
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