• N&PD Moderators: Skorpio | someguyontheinternet

Would a D1/D5 receptor full agonist have recreational properties?

I've seen a couple trip reports that found highly selective d1/5 agonists 'fun', but who knows whether the responses were idiosyncratic to the authors, since such reports are so rare (perhaps only from a single person on blacklight).
 
From that paper:

Subjective, behavioral, and physiological measures were obtained 30, 60, 90, 150, and 180 min after capsule intake.

Drug Effects Questionnaire

Subjects completed several standardized questionnaires, but here we report only on the Drug Effects Questionnaire (DEQ), which consisted of three visual analog scale items (a 100-mm line) on which subjects rated how much they felt a drug effect, liked the drug, and wanted more of the drug. For each question, an area under the curve (AUC) was calculated separately for 5, 10, and 20 mg d-amphetamine and subtracted from the placebo AUC to create an index of drug effects net placebo responding. It should be noted that these items are based on a simple visual analog scale, and because the participants were not drug users, it should not be considered a measure of drug “craving”.

The problem I've got with it here is that the participants were kept entertained with filing out this drug effects questionnaire 5 times within a 3 hour span. The subjects were drug naive as well (as far as the authors could tell), add that with the added novelty of being in a research setting and "doing drugs" for the first time and you'll probably cause some sort (although minor) of natural reward... Also looking at figure 1, the one group rated their liking of the drug just under 5 out of 10 and the other group around 6 out of 10 at the peak. Not particularly high for an intrinsically rewarding substance. 20mg is low for a recreational dose, but for a drug naive user it's too high a dose as being counted as therapeutic imo...

You can also find evidence from microdialysis studies that those compounds increase extracellular dopamine levels in relevant brain regions.
Likely involved in their reinforcing qualities and not rewarding qualities...
 
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