While I don't intend to try 4-BMC or 4-CMC - the fact that 4-Chloroamphetamine
has been used as an antidepressant in humans without adverse effects and toxicity was caused
by a metabolite in rat cells, not by the main compound itself, makes me wonder if metabolism in humans might be different enough for that given metabolite not to form?
Also it seems not to be related to MAO inhibition at all like with methedrone / PMMA.
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Edit:
Here is a disturbing report of a member who suffered probably permanent neurotoxicity from some chemical that could well have been 4-bromomethcathinone. But we don't know in the end.
Back when mephedrone was still legal and I was younger and careless, I had a weird experience from combining maybe 40mg 4-mmc of unknown purity (from a vendor that also sold methedrone) with an unknown (ranging somewhere above 100 and below 250mg) amount of dextromethorphan. Was a long-lasting, gradually building experience that got quite intensive, a little "out of it" but very socially stimulating, euphoric, lowering inhibitions and feeling toward others - so, and lacking regular - high dose experiences of mephedrone, MDMA or anything comparable, the effects read like they could have been just from the mmc or maybe a bit amplified by the dxm.
But well - the next day I woke up feeling .. different. And really not that unlike a light version of what the report above describes. This increased upon the day, in the late afternoon I walked along a street in the city I've lived in and knew very well, yet I felt like I was an alien in an alien landscape. I do not remember much more in detail, but it shocked me - and everything, even the fear and all, felt like they were not my emotions. They were there and I felt them, but like I was an emotionless being sitting behind a screen watching life's movie.
Thankfully I recovered fully after a few days, and in that time I have used DXM in low dose range almost daily too ... I'll never really know what it was, but both 4-mmc and DXM are powerful serotonergics and I guess this was too much at once. Maybe even the NMDA antagonism of DXM / its metabolite actually saved me from further damage...
Also from the day after 4,4'-dimethylaminorex (as well as from discontinuing SSRIs, to some extent) I know how serotonin depletion feels. Nothing one intends to feel, but by far not comparable.
After that I thought mephedrone just wasn't for me - but since I've got to know 3-mmc (and today I do more effort to be sure what I take) which feels completely different, much clearer and I actually enjoy it from time to time... So I think differently now about that incident.