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Bupe Wondering why it takes so long for sub to work for me?

buttershots21

buttershots21

Bluelighter
Joined
Feb 2, 2011
Messages
161
Location
Michigan
I take Morphine and percs, 120-140mg a day of percocet, 240-360 mg day morphine. Am I not taking enough Sub? I haven't had any narcotics since 7am yesterday morning, it's now 6:30pm the next day, and so far I've snorted an 8mg Subutex and dosed a 4mg strip under the tongue, which would equal a little more than 12mg because of my ROA. I've been through this a few times, and it seems like no matter how long I wait, I get no relief the first day of taking the sub, the second day isn't much better, it's not until I'm taking it for 3 days in a row that I start feeling better. Any advice on this would be great!
 
You are not taking enough buprenorphine. You are on a moderately hight dose of opiates. The reason you start to feel better after 3 days is because the morphine/oxycodone withdrawal is starting to subside at that point.
 
Well i'm no expert but if your taking 1/4 gram of morphine and 2 grains of Oxycodone every day i'm pretty sure that at doses above 4mg buprenorphine saturates your opiate receptors so heavily that it blocks other stuff from getting through..

This may not make sense, but if you reduce your Sub dose to very very low (around 1-2mg max) the Morphine and Oxy should be able to do their jobs better..i THINK, I don't KNOW though, but I know there's some pretty smart Bupeologists on here that can help you out in more detail..

Research ULD (Ultra-Low dose) buprenorphine in comination with other opiates it works....when people take 16mg a day (like for addiction reasons) it creates a blockade so that heroin and opiates won't be able to bind to the receptors and do their job, so just look into that, man..
 
Someone did a great post on the bio-availability of buprenorphine once upon a time through all its RoAs. Under the tongue is only about 30% and snorting is much better. The best RoA are IV (obviously), IM, and plugging. It could just be that the RoA you are using isnt working the best for you.
 
Wait, are you asking why your regular meds are not working after taking that dose of Sub for a few days, or why the Sub is not keeping you outta W/D when you run outta your regular meds?? If it's the first then it's because the Sub is still in your system and is blocking your morphine and oxy to some extent still. If it's the second, it can take a while for the Sub to start working before you feel stablaized. And to the person who said he didn't need that much Sub, he might need MORE to keep him stable.. That's a high dose of Morphine and a pretty good dose of Oxy daily. People with higher habbits sometimes do need up to 24mg of Subs of day to keep them feeling normal, then can reduce their dose easily once they have become stablaized on the Subs.
 
Sorry I didn't make myself more clear. Withdrawls tend to scramble the brains lol. First I take either that much morphine or that much in oxy a day, I don't take both of them together, it's one or the other. Second, I was wondering why the 12 mg of Sub wasn't making me feel better after waiting over 24 hours, ever. When I had a lower tolerance, around 100mg morphine a day, 4mg of sub would do me just fine. Third, I take all my meds orally, I may chew them but that's it. It's only the sub I snort. I get my meds tomorrow but I go through this once every few months so the info will still come in handy!
 
Im surprised you haven't gone through precipitated withdrawal... Try and wait to take the bupe until at least 48 hours since your last dose. Probably will help quite alot.
 
You don't feel well for a couple reasons. One, you want to be high and you're not, now, which sucks, but oh well.

The bigger reason is that your brain is used to full agonist efficacy at mu receptors. Now, even if you were to saturate the receptors your brain won't be as fully activated because bupe just doesn't have the ability.

I'm not sure about the intrinsic activity of buprenorphine relative to morphine, but I believe it's around 50% for a drug to be considered a partial agonist- all drugs vary a bit, but I believe 70% and up are generally considered full agonists, while those under 30% as antagonists, but to be honest I'm not sure about the demarcation lines.

I started reading this yesterday, it's worth a read for sure: http://onlinelibrary.wiley.com/doi/10.1111/bph.12222/full
 
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