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Will my 25I-NBOMe blotter tabs be active if they aren't complexed?

A

arthuraloian

Greenlighter
Joined
Jun 16, 2012
Messages
13
Hey guys, I'm is in a big time jiffy and is really worried. I have 50 1x1 cm blotters with 500 µg of 25I-NBOMe on each one. I got it from a reliable source, and was happy until I read 25I-NBOMe's bioavailability buccally, is very small, without Hydroxy-propyl-beta-cyclodextrin. This made me EXTREMELY upset. I would like to know what I could do that is basic and takes a short time. I cannot find any source that provides Hydroxy-propyl-beta-cyclodextrin other than my original source which is not accessible at the moment , so I am stuck with the blotter sheet. I wanted to know if there is anything I can do, such as dripping a solution or what ever on the blotter paper, that would increase oral absorption of the drug??? PLEASE HELP ME, this is really important! THANK YOU! By the way, this is the info I got for it, maybe it helps!

CAS: 1043868-97-8
IUPAC: 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
Other names: NBOMe-2C-I; BOM-CI; Cimbi-5; Solaris;
Formula: C18H22INO3
Mol. mass: 427.277 g/mol
Appearance: blank white blotter

P.S. Sorry Transform (moderator), I will remember not to use SWIM in the future, Thank you.
 
NBOMes can also be neutralised with acid to form a water-soluble salt which will work sublingually.

99% of NBOMes laid onto blotter will be pre-complexed or the neutral salt which means their bioavailability will be just fine sublingually. Nobody would sell any if they didn't work.
 
Yes, you told me and thank you. But the online vendor I got it from gave me the option of with or without Cylodextrin, That's why it occurred to me that he might be selling it for ACTUAL research. But I don't know. Thank you anyway, it is REALLY relieving to know that. If lets say it doesn't work, what acid would I drip on the blotter?
 
Complexing makes buccal administration more efficient. It's not to solubilise the freebase but to enhance the absorption of the salt. You don't need it but it means you are more able to get the most out of the dose without taking special precautions (holding it in the right place for 40 minutes, not swallowing your saliva, etc). 25n seems more soluble than the others so probably doesn't need complexing.
 
Okay, well in any case, whether I do go further or don't, can you specify what one should do if he were to take the blotter. Like where he would put it, on what kind of "stomach", swallow saliva or not etc.....?
 
any reason you dont hold it under your tongue but between your lip and gum, or on your actual tongue like LSD blotter? is the lip/gum bucal method really than much more effective. im not going to make a solution and water line it or try and vape (dont even know how i could vape apieve of blotter unless i stuf the whole thing in there. im getting a 1mg sample hit of 25c and i plan on taking half to get a feel for it
 
Because holding it between the lip and gum allows you to swallow and talk normally without losing the blotter. One needs to hold it for 20 minutes remember.

OP: If you decide to go further you just need to hold in between your gum and lip for 20-40 minutes. You can then swallow freely. Stomach contents are pretty unimportant. All other advice is the same as for any psychedelic.
 
Wait I'm sorry I still don't quite understand.... You recommend keeping it "Dip-Tobacco" style between the bottom lip and gums for 20-40 minutes. Ok, and I can swallow my saliva?
 
But it might be more effective if you try to hold the saliva in your mouth particularly with uncomplexed blotters.
 
Yes, my vendor just confirmed they are not complexed. So I will try to administer it buccally, but if it doesn't work, anything I can do with the sheet itself?
 
You can look at it 2 ways, right?

1. Without a complexing agent buccal or sublingual administration of NBOMe's is weak (because of limited BA), and it is reason to worry if this is the case with your product.

2. With a complexing agent, bioavailability is even higher than without. Both are perfectly fine, but one may need to adjust the dose accordingly.

It seems to me - I might be wrong - that the majority of people has view #2, so why exactly take view #1?
 
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