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Will Hydromorphone (Dilaudid) Remain Stable In Solution?

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daddysgone

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Joined
Oct 22, 2007
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1,114
hey guys
I had a question about whether or not hydromorphone will remain stable in solution.

If one were to micron filter a bunch of dilaudid pills and store the solution in bacteriostatic water, would the solution remain stable or would it degrade the same way a solution of heroin would?

About how long would this solution remain stable/active?
 
I can't give you an exact value, however, I can say with a fair level of certainty that hydromorphone will not degrade like heroin will in solution. The reason diacetylmorphine (H) is unstable in water is because of its two acetyl ester groups. The two hydroxy (OH) groups in morphine are reacted with AA (unnamed reagent) to form two acetyl esters (CH3COO-R), evolving water. This reaction is in equilibrium, therefore, the acetyl groups can be hydrolized by the water forming acetate (I think) and the (HO-R) groups on morphine.

Short answer: hydromorphine doesn't contain ester functional groups, therefore it doesn't undergo cleavage by H2O.

This is assuming that water doesn't interact in another fashion. All I am saying is that the two compounds do not undergo the same degradation. But it is possible that hydromorphine undergoes some other degradation in the presence of either water or benzyl alcohol (additive in bacteriostatic water). Hope this helps
 
Yea thats what I figured. I know it won't hydrolyze like heroin, I just was using that as example.

Basically, I am wondering if by storing the hydromorphone in bacteriostatic water, will there be any reaction or degredation of the hydromorphone due to either the water or the benzyl alcohol, or can it safely be stored in this solution for a long period of time.

I would think that it would be fine to store it like this since I know they use hydromorphone ampoules in the hospital and I believe these are stored in bacteriostatic water.
 
maybe you should just store like a couple pills like that for a while then use them and see if they feel the same. I know its not very scientific but hydromorphone has a pretty unique feel when IV'ed so you could probably tell when its changed molecularly.
 
I've created solutions to liquid measure HM from (Purdue Dilaudid 4's if it matters). The longest they've lasted were maybe 5-7 days before used but I could never notice a potency drop in the solution during that time. I'd use 50 pills (200 mg) and measure it to 10mg/ml or 20mg/ml due to tolerance and the syringes I had in abundance at the time (1/2 or 1cc, prefer 1/2).
 
Sorry, misread your question. Hydromorphone (and all the other classical non-ester opiates) are close enough to be the same in terms of chemical stability.
 
OP requested this be tried in ADD...

ADD mods, if this absolutely doesn't belong and you want to send it back, feel free.



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