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Will a Dopamine Antagonist reduce the stimulating effects caused by Dissociatives?

Ballz_Trippington

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Pretty much what the title says....
I really love dissociatives but I hate the lingering stimulation....I've never had access to Ketamine except at the odd festival when a bump was offered to me a few times....my understanding is that S-Ketamine is not particularly stimulating as its the other isomer that acts as a DRI.
And the most of the stimulation caused by dissos is from there DRI action.
I'm wondering if a dopamine antagonist would mitigate the effects of arylcychlohexelamines like MXE, O-PCE , 3-MeO-PCE , etc.
Or would this be potentially extremely dangerous to mix something like Rispiderone?
 
I'm pretty sure PCP and 3-MEO-PCP are direct dopamine receptor agonists so a sufficient dose of a dopamine antagonist will block that aspect of each drug's pharmacology.

Will it block the nmdar antagonist effects that cause dissociation, likely not.
 
I'm pretty sure PCP and 3-MEO-PCP are direct dopamine receptor agonists so a sufficient dose of a dopamine antagonist will block that aspect of each drug's pharmacology.

Will it block the nmdar antagonist effects that cause dissociation, likely not.
I think Seroquel will be a safer option than Rispiderone....and I have access to both but have never used either one..
I really can't thank you enough for your help in this matter!
 
Firstly, I cannot express my gratitude enough for all these responses by people who understand this at a much much greater level than I....
Just to be more clear, I was not intending to take a dissociative at the same time as a dopamine antagonist but when the main effects ware off in order to sleep.
I find with ultra stimulating dissos like MXE and 3-meo-pce that even whst should be a sufficient benzo dose I still can't sleep and sometimes still have residual stimulation into the next day.
So I'm more concerned about the safety of taking something like seroquel at the end of the experience when I no longer want to feel the effects of the dissociative.
Also, am I wrong in believing that S-Ketamine had little DRI activity abd it was the other enantiomer thst possessed mainly DRI activity?
 
I could very well and quite possibly interpreting this incorrectly but it makes sense but most if not all arylcychlohexelamines are chiral ?
And that one isomers tends to be mostly responsible for dissociative effects and another for DRI?
I assume this study looked at the chiral molecules not each enantiomer????
So I'm not sure if DRI activity is really neccessary for psychedelic (dissociative) effects or if it's a seperate activity caused by the other isomer?
I thought I had read this was true of MXE as well?
But I very well could be mistaken.
 
Yes, (S)ketamine is an NMDA antagonist, (R)ketamine is a DAT and possibly directly stimulates dopamine receptors (although I don't think affinity can be too good - dopamine agonists have TERRIBLE side-effects from vomiting upwards.
 
Yes, (S)ketamine is an NMDA antagonist, (R)ketamine is a DAT and possibly directly stimulates dopamine receptors (although I don't think affinity can be too good - dopamine agonists have TERRIBLE side-effects from vomiting upwards.
Please forgive me if I'm being unintentionally ignorant but would this suggest that the stimulation from dissociative is not mostly due to DRI activity?
If so, what might be the mechanism thst causes such stimulation....I have really almost no experience with S-Ketamine so I'm not sure if it's stimulationg or hard to sleep after the sedating effects wear off??
It almost feels like MXE , O-PCE and 3-meo-pce are all initially very relaxing if administered rectally to the point thst I kust want to lay in bed and close my eyes listening to music but then leads to absolutely uncomfortable long lasting stimulation ....I would like to figure out how lesson the stimulating after effects ....even large doses of benzos won't do the trick for myself.
 
Risperdal(risperidone) is a horrible drug.
You very correct ...which is why I was leaning towards seroquel....but I'd have to order bottle anđ it'll take a week to arrive...
My mother is on 1mg rispiderone for sleep but 1mg makes her incredibly groggy in the morning so we break them.in half and give her .5mg and she see.s to sleep well and wake up not feeling groggy so at the moment rispiderone is my only dopamine Antagonist on hand.
I'm just curious to see if even 0.5mg lessons the stimulation later on when I take it.
Already boofed 60mg o-pce 😎
Feeling it come on now!!!!
See ya'll in the funny pages!
Cheers
BT.
 
You very correct ...which is why I was leaning towards seroquel....but I'd have to order bottle anđ it'll take a week to arrive...
My mother is on 1mg rispiderone for sleep but 1mg makes her incredibly groggy in the morning so we break them.in half and give her .5mg and she see.s to sleep well and wake up not feeling groggy so at the moment rispiderone is my only dopamine Antagonist on hand.
I'm just curious to see if even 0.5mg lessons the stimulation later on when I take it.
Already boofed 60mg o-pce 😎
Feeling it come on now!!!!
See ya'll in the funny pages!
Cheers
BT.
Risperidone gives me akathisia and tachycardia. I only get bad side fx from it, hate that poison.
 
Please forgive me if I'm being unintentionally ignorant but would this suggest that the stimulation from dissociative is not mostly due to DRI activity?
If so, what might be the mechanism thst causes such stimulation....I have really almost no experience with S-Ketamine so I'm not sure if it's stimulationg or hard to sleep after the sedating effects wear off??
It almost feels like MXE , O-PCE and 3-meo-pce are all initially very relaxing if administered rectally to the point thst I kust want to lay in bed and close my eyes listening to music but then leads to absolutely uncomfortable long lasting stimulation ....I would like to figure out how lesson the stimulating after effects ....even large doses of benzos won't do the trick for myself.

(S)ketamine has no stimulant activity.

Studies on ketamine uncovered the fact that NMDA antagonists do produce a reward effect. Before then, it was presumed only dopamine (directly or indirectly) was the only mechanism for the reward system of the brain.

There are some selective NMDA antagonists like MK-801 (Dizocipline) that have no stimulant effects. I think their are trip reports online. But I warn you that their have been deaths associated with it's use. Not many, but then it isn't a common RC.
 
I have never seen Dizocipline anywhere but the lack of stimulantation is very intriguing....wish I had a source for (S)Ketamine up north here.
My experiment ended up being a bust as I never ended up taking the Rispiderone....my girlfriend ended up dropping 2 15mg caps of 4-ho-dipt I my mouth amd we ended up being naughty all night.....
I'm on vacation next week so I may try again.
 
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