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Will a 2mg dose of Haldol block Ketamine?

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blase deviant

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May 9, 2004
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I'm taking 2mg/day of Haldol, and was wondering if it'd block Ketamine for me, since Risperdal/Invega doesn't, but Abilify does.
 
blase deviant said:
I'm taking 2mg/day of Haldol, and was wondering if it'd block Ketamine for me, since Risperdal/Invega doesn't, but Abilify does.
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Most likely, not entirely. It should definitely affect the ketamine experience in some way, however. But I don't see it blocking the effects. If it was me, I wouldn't use the Haldol the day I planned to use ketamine, but I would use it right after the experience.

But then again, if you are taking anti-psychotics, you probably should NOT be using ketamine anyways. You're probably just asking for a psychotic break for a good hour.
 
It will block the dopaminergic effects of ketamine, but I don't think it does much for the NMDA mediated effects. It had chance to feel like some zombie delerium.

Anyway, by the time it started to work, you'd be mostly out of the ketamine experience so it seems a bit pointless. Benzos & ketamine produce lots of amnesia, but at least it isn't the zombie delerium show!
 
fastandbulbous said:
It will block the dopaminergic effects of ketamine, but I don't think it does much for the NMDA mediated effects. It had chance to feel like some zombie delerium.

Anyway, by the time it started to work, you'd be mostly out of the ketamine experience so it seems a bit pointless. Benzos & ketamine produce lots of amnesia, but at least it isn't the zombie delerium show!
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I'm sorry, but what do you mean by 'by the time it started to work'?
 
I take it nightly though, so wouldn't plasma levels still be high enough to block it the next morning and throughout the day?
 
Love In Vein said:
But then again, if you are taking anti-psychotics, you probably should NOT be using ketamine anyways. You're probably just asking for a psychotic break for a good hour.
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I fully agree. Ketamine is a drug to stay away from if you have a psychotic mental illness.
 
>>It will block the dopaminergic effects of ketamine, but I don't think it does much for the NMDA mediated effects.


Exactly. A recreational dose of Ketamine will blast right through the Haldol.

If you take Haldol against psychosis, you *really shouldnt use Ketamine*.

Any way you turn it, Ketamine is a PCP derivative. These should be avoided like the plague by people with a predisposition for psychosis. Ketamine for those people is way up there with meth and crack as to the risk of activating a psychosis.
 
All dissociatives (except maybe nitrous) should be avoided by people with psychotic tendencies.

I'm not sure whether PCP is technically a derivative of ketamine, but the two have similar chemistry and pharmacology.
 
5-HT2 said:
people with psychotic tendencies
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Lately I've been wondering about people suffering from and/or diagnosed with mental illnesses.

It seems that a large % of Bluelight forumites and even moderators believe (justified or not) that there's something wrong with them and take daily meds for that reason.

Is this % a common average or do these people really tend to use psychedelic drugs more readily than "normals"?

If so, why? Are they trying to heal themselves, are they trying to fuck up their brains some more (it's a common belief that taking psychedelic drugs is very risky for people with mental afflictions) or is there some other reason?

I'm also under the impression that "doctors" have been exponentially increasing the number of prescriptions for the past 30 years or so (especially but not exclusively in the USA), and it has become not-quite fashionable to do SSRI's, with I might add, results that are less than great for many users.

Do we see virtual epidemics of mental disease or is it something else?

Of course it's quite easy to convince almost anybody that they suffer from a mental disease as everyone knows that "normal" people are perfectly stable, confident and don't have internal conflicts. ;)

Hm maybe I should start a separate thread on this. I'll click Submit Reply while I consider it.
 
I'm not sure whether PCP is technically a derivative of ketamine, but the two have similar chemistry and pharmacology
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Ketamine is actually a derivative of PCP, not the other way around. Parke Davis had PCP in the 50's and ketamine didn't make a clinical appearance until the early 60's (them - Parke Davis - again. They are to dissociatives what Sandoz is to psychedelics!)
 
Just like psychedelics come as phenethylamines and tryptamines, the PCP family consists of arylcyclohexylamines.
 
As long as it doesn't block it, I'll probably do it.

I'd prefer opiates, but according to one site, I have to take 50% of the dosage with opiates on Haldol, so I'd get no euphoria.
 
fastandbulbous said:
It will block the dopaminergic effects of ketamine, but I don't think it does much for the NMDA mediated effects. It had chance to feel like some zombie delerium.

Anyway, by the time it started to work, you'd be mostly out of the ketamine experience so it seems a bit pointless. Benzos & ketamine produce lots of amnesia, but at least it isn't the zombie delerium show!
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But Abilify has nothing to do with NMDA, and it blocked Ketamine as well...
 
^ Done.

Interesting thread. Antipsychotics, AFAIK, block a lot more than just DA. I wouldn't be surprised if they block whatever currents/cascades that result from Ketamine intake, despite not affecting its NMDA antagonism.
 
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