Wikipedia - 4-methylaminorex updated

[almost-]

http://en.wikipedia.org/wiki/4-Methyl-aminorex

English isn't my first language so please correct if there are any mistakes.

 

[egor]

Nice, I didnt see any mistakes

 

[Jamshyd]

Thanks, well-written, and I don't see any glaring errors. I do have a few "cosmetic" suggestion that i'll post once I'm done reading. However, I would like to note one thing now: is Pemoline really considered non-addictive?

 

[fastandbulbous]

^ Yes because of it's (pemoline's) very slow onset & prolonged action (and it's subtlety compared with most psychomotor stims). Of course hepatotoxicity make abuse liability take a back seat - hence it's removal from most country's approved drugs

 

[J. Alfred Prufrock]

There's a typo here:

"The United States [Drug Enforcment Administration] has the following opinion on the legality of the positional isomer "trans"-4-methylaminoaminorex, which, unlike its 'cis' isomer was never placed in any schedule under the Controlled Substances Act."

Need to drop the "amino"

 

[fastandbulbous]

So the DEA don't have much of a clue as to what they're scheduling, just doing knee jerk emergency schedulings when a new drug appears. Why am I not at all shocked? 8)

 

[LuxEtVeritas]

^^^

well they know they can call just about anything an analogue anyway so i guess they fall back on that

who knows what they are thinking as it certainly is not a logical approach

but how long has it been since the US policies have been logical

 

[almost-]

Added something more. This one:

In 1970s McNeil Laboratories, Inc was trying to bring 4-methylaminorex to drug market as a sympathomimetic (most commonly used as asthma-medicines), research name was McN-822, they mention that human dose would have been 0,25mg. They mention also LD50: 17mg./kg./p.o./m. [7]

There is a patent about the use of 4-methylaminorex "as a nasal decongestant which, when administered orally, does not produce adverse central nervous system stimulant effects as experienced with other decongestants and anorexiants." Dose mentioned is 0.25 mg/kg of body weight.[8]