PlurredChemistry
Bluelighter
Well, i know why...but why not use LC/MS?
Anyone out there know?
Anyone out there know?
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RT&DC Moderators: Senior Staff
Why Use GC/MS?
- Thread starter PlurredChemistry
- Start date
monsignore
Bluelighter
sorry, but what hell is LC /MS ???
PlurredChemistry
Bluelighter
Liquid Chromatography/Mass Spectrometer
it does pretty much the same thing as GC/MS, i'm just curious why GC/MS seems to be favored for pill testing...
[ 10 July 2002: Message edited by: PlurredChemistry ]
it does pretty much the same thing as GC/MS, i'm just curious why GC/MS seems to be favored for pill testing...
[ 10 July 2002: Message edited by: PlurredChemistry ]
probably several reasons... LC depends on solubility of the various solutes in the solvent phase chosen - that's the biggest thing, as GC/MS is used for identification of every substance in a complex sample, and the testers don't need to worry about solubility.
GC/MS is just better suited for drug samples -- the GC phase depends on melting point and the vapor pressures of the substances, so you don't need to choose a solvent phase.
LC might be better-suited for identification just by itself, since GC results are only consistent for a given column under the same conditions (same temperature, etc), while LC might be a bit more standardized. in GC/MS, the only purpose of the GC is really to separate the compounds before you analyze them with MS.
GC/MS is just better suited for drug samples -- the GC phase depends on melting point and the vapor pressures of the substances, so you don't need to choose a solvent phase.
LC might be better-suited for identification just by itself, since GC results are only consistent for a given column under the same conditions (same temperature, etc), while LC might be a bit more standardized. in GC/MS, the only purpose of the GC is really to separate the compounds before you analyze them with MS.