Misc Why only some people get MMDA from consuming Nutmeg

[The Holy Quadruplty]

It is widely theorized that the psychoactive effects of consuming large doses of nutmeg are due to the body's metabolism of myristicin into the amphetamine-like compound MMDA. While this is the prevailing theory, scientific studies have noted significant variability in human metabolism and the effects of nutmeg, suggesting that not everyone experiences the same degree of conversion or response.

Variability in Metabolism and Response

• Enzyme Activity: The conversion of myristicin into MMDA is believed to be facilitated by the CYP1A1 enzyme in the liver. Genetic variations in the activity of this and other drug-metabolizing enzymes (CYPs) are common among people, which likely explains why some individuals report strong hallucinogenic effects while others experience little to no high, but suffer from the general toxic symptoms instead.
• Case-by-Case Symptoms: Reports of nutmeg intoxication are limited to case reports, and symptoms can differ significantly on a case-by-case basis. This suggests an individual response rather than a uniform effect across all individuals.
• Lack of Detection in Humans: Although MMDA has been identified as a metabolite in animal studies (rats and guinea pigs), it has not been consistently detected in human urine samples following nutmeg consumption in all studies. This further supports the idea that the metabolic pathway leading to MMDA may be less common, highly variable, or simply difficult to detect with current methods in humans.
• Other Compounds: It is also possible that other compounds in nutmeg, such as elemicin, contribute to the overall psychoactive and toxic effects, potentially through synergistic mechanisms.

In essence, while the metabolic pathway to MMDA likely exists in humans, its efficiency and impact appear highly individual-dependent and may not occur in everyone.

This could be one of the reasons only some people can get "high" from consuming Nutmeg, but not the only one.

 

[JackARoe]

I too would love to try MMDA. It has been in the literature for years. Even before MDMA I think.

I never gave fresh nutmeg a good try. But I gave the powder a try and it did was make me sleepy. Also, I was a kid, like 16.

If it’s true, the body can convert parts of nutmeg into MMDA then there must be some mechanism to get that to work for everybody. Something silly like take a tablespoon of sugar with it. Who knows.

THQ I’m glad you’re curious about this area of drugs than the deliriants. I cannot criticize because I’ve never used even really Benadryl. I tried that stuff a few times when I was young with a cold and it made me feel crappy. So I can’t comment on the higher doses, but it doesn’t sound nice for the brain like psilocybin can be. I’m sure there are plants that are better than the man-made deliriants.

Nutmeg needs a lot more attention. By this time next year, I want a full report on how to get that stuff converted into something useful.

 

[The Holy Quadruplty]

I too would love to try MMDA. It has been in the literature for years. Even before MDMA I think.

I never gave fresh nutmeg a good try. But I gave the powder a try and it did was make me sleepy. Also, I was a kid, like 16.

If it’s true, the body can convert parts of nutmeg into MMDA then there must be some mechanism to get that to work for everybody. Something silly like take a tablespoon of sugar with it. Who knows.

THQ I’m glad you’re curious about this area of drugs than the deliriants. I cannot criticize because I’ve never used even really Benadryl. I tried that stuff a few times when I was young with a cold and it made me feel crappy. So I can’t comment on the higher doses, but it doesn’t sound nice for the brain like psilocybin can be. I’m sure there are plants that are better than the man-made deliriants.

Nutmeg needs a lot more attention. By this time next year, I want a full report on how to get that stuff converted into something useful.

The report, yes!

I find it interesting that Myristicin can be metabolized into MMDA threw CYP1A1, and that inducers of it make more MMDA from Myristicin. I do various other drugs as you know, and 2 of them that I know of are indeed inducers of CYP1A1. Subutex, and cigarettes are the 2 I know of at least, and honestly everytime I do my Subutex, or smoke a cigarette I start to feel tripper/brighter colors/other psychedelic like effects.