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  • BDD Moderators: Keif’ Richards

Why isn't there a drug out there with no tolerance build up or withdrawals?

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Methadone84

Methadone84

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I know this sounds crazy but it is 2011 after all. Just imagine taking hydros/oxys without having to worry about tolerance and withdrawals. Cmon people
 
Salvia supposedly has a reverse tolerance. Dont ask me how that works
 
Methadone84 said:
I know this sounds crazy but it is 2011 after all. Just imagine taking hydros/oxys without having to worry about tolerance and withdrawals. Cmon people
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It doesn't sound particularly attractive to a pharmaceutical company from a business perspective, does it?
 
It's just your body's natural response to establish and maintain a "steady state." Once introduced to a foreign substance, your body will naturally try to metabolize it and move it out of your system. Your body also has an incredible ability to remember substances previously introduced into the body, and deal with them in a more efficient manner the second, third, fourth times,etc....
 
TheBacon said:
It doesn't sound particularly attractive to a pharmaceutical company from a business perspective, does it?
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This!! I'm sure there's some methods they could look into, but why in the world would they spend money and time researching something that ultimately is going to make them lose money?

Tolerance and omedown free amphet would be damn near the perfect droog
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Add neuro-PROTECTIVE to that list and yes, you have the perfect drug.
 
It is a great idea but I don't think there ever will be a product out there that will be tolerance proof. When a drug is ingested over and over for a course of over a few months your brain will naturally become tolerant to that certain substance in where's you have to increase the dose to get the same effects. You will suddenly feel the need to take more. Now that all these narcotics have been consumed, your brain will have a hell of a time if it doesn't have some of those neurotansmitters floating around their mu receptors (responsible for pain). So if some are taken away, there are less neurotrasmitteres floating around and the receptors sites, specifically the mu receptor are receiving less. Therefor you go into slight withdrawal. If you take a lot away you experience some pretty bad withdrawals. It just won't work. So there will never be a tolerance/withdrawal free opiate
 
Nitrous doesn't seem to have any tolerance or withdrawal issues. Three whipits gets me to the same place it always has. If anything, there is evidence that it has reverse tolerance.
 
Taking psychoactive drugs means playing with neurotransmitters and/or hormones. How do you expect body not to react to it at all? It gets used to the new situation with repeated use of drug X and then homeostasis "changes", body won't accept another new situation as quickly. When you start taking opioids, it also doesn't get used right off but then for person X it doesn't equal any uncomfortable effects so it's "alright". Well, when you stop doing opioids, body needs some time to get used to again and psychologically it may never get back to the state before any drug intake because what happened to body wasn't really natural. It has its own opioid system and suddenly there appears some compound that does the job of endogenous opioids, moreover there's more of it than for keeping homeostasis, when your body gets used to the situation, you're addicted, your body doesn't treat opioids from outside as intruders.

Your question is actually about a few things, not only one because tolerance build-up and withdrawal isn't always connected (for opioids methadone is moderately addictive, it causes withdrawals but tolerance to it doesn't build up that fast, that's why people on MMT can stay on the same dose for years).
 
Whipped Dream said:
It's just your body's natural response to establish and maintain a "steady state." Once introduced to a foreign substance, your body will naturally try to metabolize it and move it out of your system. Your body also has an incredible ability to remember substances previously introduced into the body, and deal with them in a more efficient manner the second, third, fourth times,etc....
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The trick is to create a drug that the body wont remember previously taken in. This way there wouldnt be tolerance.
 
adder said:
Taking psychoactive drugs means playing with neurotransmitters and/or hormones. How do you expect body not to react to it at all? It gets used to the new situation with repeated use of drug X and then homeostasis "changes", body won't accept another new situation as quickly. When you start taking opioids, it also doesn't get used right off but then for person X it doesn't equal any uncomfortable effects so it's "alright". Well, when you stop doing opioids, body needs some time to get used to again and psychologically it may never get back to the state before any drug intake because what happened to body wasn't really natural. It has its own opioid system and suddenly there appears some compound that does the job of endogenous opioids, moreover there's more of it than for keeping homeostasis, when your body gets used to the situation, you're addicted, your body doesn't treat opioids from outside as intruders.

Your question is actually about a few things, not only one because tolerance build-up and withdrawal isn't always connected (for opioids methadone is moderately addictive, it causes withdrawals but tolerance to it doesn't build up that fast, that's why people on MMT can stay on the same dose for years).
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Whats MMT?
 
LSDMDMA&9316621 said:
Tolerance and omedown free amphet would be damn near the perfect droog
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That x pill in you avatar are the Mitsubishi's. right? I remember those, great pills & awesome times.
 
killermunchies said:
Nitrous doesn't seem to have any tolerance or withdrawal issues. Three whipits gets me to the same place it always has. If anything, there is evidence that it has reverse tolerance.
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This is correct. I don't believe there are any tolerance issues with Nitrous. Neither are there any withdrawals.

I don't believe there is tolerance issues with mushrooms either. I've never heard of someone that has to keep taking more and more to get the same high. Of course, there are no withdrawal symptoms.
 
RobbyG said:
Ghb has no tolerance but there is withdrawals if you abuse it daily
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GHB absolutely exhibits tolerance. Ask in the addiction thread in EADD if you've not experienced them yourself.
K'd-OUT-in-AZ said:
I don't believe there is tolerance issues with mushrooms either.
I've never heard of someone that has to keep taking more and more to get the same high. Of course, there are no withdrawal symptoms.
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Mushrooms also cause tolerance, although, as with other tryptamines it builds and diminishes very quickly, a matter of days. This means that people who use even weekly will find themselves building little tolerance, if any.
 
This thread really isn't suitable for the way BDD is run now, it is not really suited for Drug Culture or any of the other forums either.

These kinds of posts would be welcome in the ???|*!*|The BDD Social and Information Booth|*!*|??? though.

Please can we try not to drag up old threads that are more social in nature.
 
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