• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Why is pure Codeine more euphoric than Codiene plus paracetamal?

D

Dr. Beat

Bluelighter
Joined
Apr 1, 2002
Messages
511
Location
Melbourne
I have personally found that 120mg of pure codeine is MUCH more euphoric than 120mg of pure codiene plus 2000mg of paractamol (4 Panadine forte's)

I got the pure codiene (30mg) from a friend who owns a horse and the horse ran into a fence and got injured. I also have got pure codiene from Cambodia (was made in France so it was good quality).

I have tried pure 120mg codiene about 10 times in my life, and had 4 Panadine fortes together about 100 times in my life, and the pure codiene is always much better.

does the paracetamol compete with the codiene ?

I have read somewhere that paracetamol hits opiate receptors - is this true ?
 
The paracetamol/codeine mixture tablets will take longer to disperse in the gut (and hence be absorbed into the bloodstream) than tiny, tablets containing codeine alone. That'll mean that you get a higher peak plasma level with the codeine alone tablets.

I think you'd find that if you were comparing soluble/dispersable co-codamol (paracetamol & codeine) with a solution of codeine alone, you'd not notice a difference
 
Ya know, i've always seemed to feel a difference between hydrocodone with no APAP, or like 10mg with 325mg, compared to 10mg/750mg, or two 5mg/500mg's.. the less APAP, the better it feels..

Also seems like the only times i've thrown up taking hydrocodone is when i've ingested a lot of APAP.
 
And big abouts of APAP will decrease the oxidative capabilitiy of the liver... and reduce the conversion of codeine to morphine (I think).
 
Two main reasons: one is because almost all codeine Rx's in the US are in the Schedule III class. Some schedule V cough medicines are out there. The codeine has to be combined with APAP, or guifenisen, etc. The other factor is bioavailabilty. Codeine is combined with a salt. To be a C-III it is phospate, thus Codeine phospate. Pure codeine does not have to "dissolve" from this salt to become avail to opiate receptors therefore the effects are acheived quicker and more pronounced. Approx ten percent of codeine is converted by the body into morphine. The quicker this can happen, the more effect. Finally, codeine combined with the salt sulfate is a C-II drug in the US. Again, codeine will release from the sulfate faster than it will the phosphate, so the the FDA made it a C-II. Never inject codeine IV because of the histamine release - anaphylaxsis, which can be fatal, damn unpleasant, and an uncomfortable explaination to the ER doc.
 
Views: 2,475

Replies: 8

I guess alot of people were expecting something more exciting.
 
^ LOL.

Still interesting 4-year old thread...

I know I will personally pick Codeine+Caffeine+Aspirin any time over the exact same dose of Codeine+Caffeine+Acetaminophen. I always thought it might be my body just saying "yuck" to the APAP, or that Aspirin potentiates the analgesic effects better than the APAP. Not sure though...

Btw this is so much so that when I was addicted to codeine, and I ran out, I had a bottle of Cod+Caf+APAP at home, yet for some reason I decided to ge and buy a Cod+Caf+Asp. Very strange.
 
Jamshyd said:
^ LOL.

Still interesting 4-year old thread...

I know I will personally pick Codeine+Caffeine+Aspirin any time over the exact same dose of Codeine+Caffeine+Acetaminophen. I always thought it might be my body just saying "yuck" to the APAP, or that Aspirin potentiates the analgesic effects better than the APAP. Not sure though...

Btw this is so much so that when I was addicted to codeine, and I ran out, I had a bottle of Cod+Caf+APAP at home, yet for some reason I decided to ge and buy a Cod+Caf+Asp. Very strange.
Click to expand...

Aspirin has blood thining properties that Tylenol does not, so that may have to do with delivery but be careful: shooting Percocet is one thing but I know someone who lost his leg shooting Percodan into his foot: mainlining acetyl salicylic acid is not a good idea because just causing stomach ulcers orally etc, both APAP and Aspirin have their very destructive strains on the body in high doses and want to be avoided at all costs if you're just trying to get an opiate out from the mix.

(Also considering the difference between codeine/hydrocodone etc and Aspirin over APAP I believe what user BilZ0r had to say on APAP interfering with the oxidative capabilitiy of the liver since it is used more heavily for its own metabolization may have the most to do with it.)
 
Last edited:
Err I'm not sure where you got the idea that I'm IVing it :). It is codeine after all ;). I do a CWE and take it rectally. However, there certainly would be a tiny bit of the aspirin in the solution...

That said, how does the blood-thining make the aspirin more recreational?
 
^My assumption was increased BBB penetration through to different areas where active in vivo in a minisculely speedier degree, though that's just likely a silly assumption.
 
yaesutom said:
Ya know, i've always seemed to feel a difference between hydrocodone with no APAP, or like 10mg with 325mg, compared to 10mg/750mg, or two 5mg/500mg's.. the less APAP, the better it feels..
Click to expand...

Hydrocodone with no APAP? I've never seen that, whats it called?
 
No doubt. I've had straight 60mg codeine tabs & 180 mg of those puts me in a much better place than 250mg taken using a CWE; however i'm sure that i only get around 70% out of a CWE so it's anybodys guess what's in the final extract...
 
Ever heard of drug synergy? Unless you have some kind of adverse reaction to the APAP you should feel better than just plain codeine. On the other hand, the binding process of the codeine/apap might of taken the reaction time of some of the spontaneous effects of codeine. Also, I wouldn't trust the purity and dosage of anything made by GSK.
 
You must log in or register to reply here.
Top