Why is it impossible to stay high on opioids for the rest of your life?

[Paregoric Kid]

what about taking something that would increase the number of mu receptors? I remember reading somewhere that cocaine caused the brain to produce more mu receptors, don't know how true that is but maybe that would be useful for people with massive tolerances.
herkinorin supposedly takes much longer to develop a tolerance to and that tolerance to herkinorin is caused through other mechanisms than the way tolerance to traditional opiates/opioids occurs.

 

[Lady Codone]

Are you guys ignoring the possibility of "overdose"/toxicity here, or is it impossible to overload your organ systems with an extremely high dose of opiates? I understand that they don't cause chronic bodily damage in and of themselves and are relatively benign, but too much of ANYTHING can lead to death, right?. Even cannabis could (theoretically) cause death through THC toxicity, even though it's not physically possible to ingest enough weed in a short enough amount of time to induce death. Hell, even water can kill you if you take in enough too fast. So why not opiates? Does the physical tolerance increase along with mental tolerance, or is it possible to poison yourself with opiates even with a high mental tolerance? Or would a person inevitably vomit up their dose and avoid getting higher because of it? It seems that before you had the chance to saturate your receptors by taking an infinite amount of opiates, your physical body would rebel either by ejecting the substance or giving out from toxicity.

 

[morphonorconic]

^Very good point. Many if not most of the common opioids do in fact produce some, albeit miniscule amounts, toxic metabolites; Hepatoxic, Neurotoxic, etc. Others, such as Meperidine/Pethidine have been shown to rather quickly build unsuitable concentrations of toxic metabolites.

I like Tsukasa's idea, as I have thought along similar lines; Switching between opioids that have little or no cross tolerance, or simply rotating between every possible opioid you like, or have access to, depending on the situation(though I think this is more or less a hypothetical discussion anyways). By doing this, as well as using any possible known tolerance combattant methods such as the use of CCK Inhibitors like Proglumide, NMDA Antagonists(Ketamine, DXM, and PCP Baby! J/K), ULD/Low Dose Naloxone/Naltrexone, etc., I think one would be able to curb tolerance as much as anyone could ever hope.

 

[Doctor Abalaba]

The question is no, not with a single drug. Likely liver, perhaps even other organ difficulty eventually. Also, post 22 was beautifully put- at some point your brain is going to 'mistake the high for sobriety.' I contend that is a certainty.