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Opioids Why is hydrocodone so stubborn?

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Bluelighter
Joined
May 4, 2012
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503
Location
New Jersey
I'm curious as to why all forms of hydrocodone come with acetaminophen (or ibuprofen) while other stronger opiates like oxy, morphine, and dilaudid does not?
 
They are coming out with Zohydro, which is an ER version of hydrocodone, with no acetaminphen. The common belief for why all hydrocodone currently comes with tylenol or ibuprophen is that these combinations are not scheduled II like the meds that are not compounded with tylenol or whatever else, giving the doctors a pain medication that they can prescribe which allows for you to get refills, since schedule II medications are not allowed to be prescribed with refills, but scheule III is.
 
so oxys with acetaminophen are eligible for refills and also makes it schedule 3? interesting.
 
^ No they are not, but oxycodone is considered to have a higher potential for abuse, therefore all preparations of it are schedule II.
 
I think the main reason why the less stronger narcotics have APAP is that the APAP potentiates the pain relief of those medications.
 
Donewthislife said:
I think the main reason why the less stronger narcotics have APAP is that the APAP potentiates the pain relief of those medications.
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I actually don't believe this to be true. Acetomeniphen is nothing compared to a drug like oxycodone in terms of analgesia, and it is also really bad for your liver. They are combined to persuade abuse, or at least that's what I believe.
 
My opinion isnt as well formed as some of the others, but I would suggest that the reason it has APAP is because it it prescribed more easily than heavier narcotics. Hydrocodone is on the lower end of the painkiller spectrum, so its easier to fake a condition which would warrant a hydrocodone prescription. So they cut it with tylenol to make it harder to abuse. Dilaudid though, is for extreme pain. The kind of pain which is MUCH harder to fake. I guess then there are reasonably a higher percentage of legit dilaudid users than hydrocodone users, so they reduce the apap so severe pain management patients can actually almost cope with their pain.
 
I think the answer may be a combination of the two scenarios listed. It initially may have been combined with tylenol to help a little with the pain, but it was probably kept that way to dissuade abuse, and to have a drug preparation that doctors wouldn't be so hesitant to prescribe, along with the added benefit of refills being allowable by law.
 
The thinking is that hydrocdone is harder to overdose on and therefore by combining each pill with a minimum of 325 mg of tylenol (norco) they believe they are ensuring there is as minimal a risk of overdose as possible. Knowing that hydrocdone can come with up to 750mg of tylenol per pill is also evidence of this strategy as no physician can say that that much tylenol is necessary for a synergistic affect with the opiate.
 
I think the apap does help with the hydrocodone to battle the pain better. When I use to use OC's once in a while, the high felt way better when I would add a tylenol with it. It also helped more with the pain. I do prefer morphine or anything else w/o tylenol but for some reason, to me at least, the tylenol helped.

Also, from what ive read, Zohydro is coming out in 2013 unless it was pushed back. I can see people snorting these bad boys like the old OC's :)
 
^ Meh, I'm not sure that many [knowledgeable] people will be sniffing them. I'm sure the new generation of pill heads who sniff anything and everything will do so, but those with any experience with the drug will probably just be happy to not have to do a CWE to get high from it. I'm not sure of what the nasal BA is (never had a reason to look it up before, and I don't think much research has been done on it) but the oral BA is very high, so I wouldn't bother messing with putting them up my nose. The only pill that I would still sniff is hydromorphone, or any of the old school Opanas that might be floating around.
 
Tommyboy said:
^ Meh, I'm not sure that many [knowledgeable] people will be sniffing them. I'm sure the new generation of pill heads who sniff anything and everything will do so, but those with any experience with the drug will probably just be happy to not have to do a CWE to get high from it. I'm not sure of what the nasal BA is (never had a reason to look it up before, and I don't think much research has been done on it) but the oral BA is very high, so I wouldn't bother messing with putting them up my nose. The only pill that I would still sniff is hydromorphone, or any of the old school Opanas that might be floating around.
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Ive had the pleasure of snorting hydromorphone & it is awesome......never had the pleasure of the old Opanas so I will never know. If the Zohydros are anything like when I use to do CWE on 4 (7.5/750's), the high was good but a bit fiendish after it wore off.........
 
^ Redosing hydrocodone never did much for me other than making me zoned out and tired. If a dose wore off I would have to at least take a nap before getting high off of it again, but usually waited until the next day. I could only successfully redose if I caught it at the peak or just after and redosed then, or if I didn't take enough to feel it much earlier in the day, and still wanted to get high later in the day.
 
For some reason, MG for MG, HydroCodone is just as strong to me as OxyCodone...I feel just as sedated off 90mg of HydroCodone as I do off 90mg of OxyCodone....anybody know why?
 
JusTrynaNod said:
For some reason, MG for MG, HydroCodone is just as strong to me as OxyCodone...I feel just as sedated off 90mg of HydroCodone as I do off 90mg of OxyCodone....anybody know why?
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I don't know why, but hydrocodone for me is stronger than oxycodone. The highs aren't exactly the same, so its not apples to apples. im pretty sure oxy is a full opioid agonist and hydrocodone is only half or something like that.
 
Hydrocodone is the one opioid that I feel you must fully come down from the high (5-6 hours) before you can try and redose and expect to get high again. Redosing too soon, as Tommyboy said, just leads to being tired and getting some good analgesia.
 
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