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why is dxm bad to mix with other drugs?

T

toxide

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Mar 21, 2006
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not sure if this is the right for forum for this but
Why is DXM bad to mix with E
why is it bad to mix with MAOIs I spoke with my doctor who's very good in his field about this and he says that dxm+maois like moclobemide are not dangerous at all, only if the dxm preparation contains sertain antihistamine or pseudephed type drugs

if dxm+e causes serotonine syndrome how exactly does it cause this
 
this is from the will white faq. i cant vouch for it's legitimacy, but since there are no replies so far i thought i'd toss it in.

"
13.3 DXM + Amphetamines and Other Psychostimulants

This is probably asking for high blood pressure problems, strokes, brain hemorrhages, and the like. While a few people enjoy this combination, most find it unpleasantly speedy anyway. Most who've tried it reported that DXM will potentiate other stimulants. Since DXM inhibits dopamine reuptake, combining it with a dopamine releasing agent (amphetamine or methamphetamine) will naturally produce a combined, synergistic effect. I'd suggesting avoiding this at all costs.

Combining DXM, a psychostimulant, and a monoamine oxidase inhibitor is a sure way to make your blood pressure skyrocket and will probably kill you (if you're lucky) or leave you with severe brain damage (if you aren't lucky).
"
 
why is it bad to mix with MAOIs I spoke with my doctor who's very good in his field about this and he says that dxm+maois like moclobemide are not dangerous at all,
Click to expand...

I gather his field isn't pharmacology! DXM in doses that it's used as a cough suppressant most probably isn't too dangerous with a reversible MAOI (not not most clinical MAOI's as they're irreversible/non-competetive), but at dissociative doses it's a bad, bad combination that'll al;most inevitably end in a visit to A&E/ER part of hospital

As to DXM & E, DXM is a serotonin reuptake inhibitor. That combined with its other actions means that your body temp will go through the roof (malignant hyperthermia), which is a very unpleasant way to die
 
toxide said:
not sure if this is the right for forum for this but
Why is DXM bad to mix with E
why is it bad to mix with MAOIs I spoke with my doctor who's very good in his field about this and he says that dxm+maois like moclobemide are not dangerous at all, only if the dxm preparation contains sertain antihistamine or pseudephed type drugs

if dxm+e causes serotonine syndrome how exactly does it cause this
Click to expand...

Ok, dude, Mixing DXM with E is just stupid as hell. They both work to increase the production of and decrease the reuptake of serotonin. That's just begging for serotonin syndrome. Mixing anything with MAOIs is a mad idea in general. And as for mixing DXM with other things, it PROBABLY wont kill you, but since DXM is a dissociative that works on brain chemicals, mixing it with other brain drugs is a bad idea, and mixing it with a 'body' drug is asking for a bad trip. They're opposites practically. DXM dissociates your mind and body, so why take it with a body drug?
 
toxide said:
not sure if this is the right for forum for this but
Why is DXM bad to mix with E
why is it bad to mix with MAOIs I spoke with my doctor who's very good in his field about this and he says that dxm+maois like moclobemide are not dangerous at all, only if the dxm preparation contains sertain antihistamine or pseudephed type drugs

if dxm+e causes serotonine syndrome how exactly does it cause this
Click to expand...

hey toxide,

i take moclobemide and i just wanted to expand on something fastandbulbous said. he referred to a reversible MAOI -- the technical term is a RIMA, a reversible inhibitor of monoamine oxidase, the chemical that destroys excess neurochemicals in the space between neurons. whereas a MAOI kicks around for up to thirty days after you take it, a RIMA is 'reversed' (undone) by the brain in 1.5 to 3 days, so (i think?) concentrations are much lower.

some chemists and doctors will be super-careful and tell you not to mix moclobemide with psuedoephedrine or illicit drugs, but others will tell you it's pretty safe. in my own experience, i've taken mdma on top of it without hassles, although you'd always always take a half first to see how you go with it, and you could apply the same dosing strategy to DXM or whatever.

however, in OTHER people's experience, as various coroners' reports will tell, mixing moclobemide and ecstasy or another SSRI proved fatal!

my theory is maybe the ecstasy users who took moclobemide to amp up the effects of their trip were not using it otherwise as an anti-depressant. i'm pretty sure it's like any drug affecting a major neurochemical -- if you take it your brain is gonna adjust in expectation of its presence over time -- whereas if you took it for the first time with a dose of MDMA it might have a worse effect. i'm not sure. your results may vary...

lxvxjxnkie
 
I think it's because DXM is processed in your liver. It can damage your liver if taken with other drugs that effect it and even if taken enough alone. The other ingredients in cough syrup (besides DXM) might effect it too.
 
I was only asking about reversable maoi-As like harmaline or moclobemide, My doctor has Very extensive knowledge of pharmacology infact, he's one of the top in his feild. He also know I take rec drugs. But I never told him specificly i was taking pure dxm recreationaly.
MaoiAs I thought have more todo with breaking down chems in the body, not the brain?
 
MAO-A has jobs to do all over the body, both within & outside the brain. Ask him (your doc) about dissociative doses of DXM & competetive MAOIs - if he's on the ball, you'll most probably get a lecture about the danger; there's a huge difference between a cough supressing dose (15mg) and a dissociative dose (600mg+) - a 40 fold difference, minimum and that's the difference between potentially some side effects & being a vomit covered corpse...
 
Going around in circles here, because fastandbulbous doesn't know about reversible inhibitors of monoamine oxide A. RIMAs are not competitive MAOIs...

Question for toxide: if he's such a hot shit doctor, why don't you level with him and tell him the whole story? why are you asking us here?
 
Its simple really,

MAOIs mixed with damn near anything is an extremely BAD combo. MAOIs prevent your enzymes from breaking down chemicals in your body so the chemicals are still able to do their job, but they never stop. This basicaly means you will overdose on a normal dose of any recreational drug. Depending on the overdose limit, you can suffer minimal health effects to brain damage to death. Its not a good idea to mix this stuff together.

DXM works on several receptors but primarally on seratonin receptors. Ecstasy does likewise, as do SSRIs. Combining any of the above 3 is bad. If you do DXM and Ecstasy you will likely dump a massive quantity of seratonin with no way to uptake it back into your neurons. This means you will be overdosing on seratonin (seratonin sydrome) which can potentially kill you. This can happen on the following combos:

DXM+MAOI
DXM+SSRI
DXM+MDMA
MDMA+MAOI

and many other combos as well.


Most importantly, if you are taking any kind of prescription drugs like MAOIs or SSRIs just avoid drugs altogether especially MDMA / DXM. I mixed various combos of these at one point in my life and it is EXTREMELY DANGEROUS. Its also not any fun whatsoever and even if you make it through it ok (like me) you still don't know what the end result will be on your brain chemistry.


Lastly, for safety sake I personally recommend not mixing anything with DXM. DXM is an extremely powerful substance that isn't given a lot of respect. First of all, if you are hyper sensitive to it because you lack a specific liver enzyme, you will have a much different and probably terrifying experience than others would have on a similar dose. Secondly, it effects a huge number of pathways in the brain. It is not a 'simple' drug it is extremely complex and acts in many different ways especially on your seratonin system which in my experience, is the one you want to fuck up the least because it has so many key roles in the body and mind.
 
yeah, why the hell woudl you want to mix dxm with anything. its a stupid drug about the 4th time you do it
 
Not really.. I used it somewhere around 8-10 times and in the proper setting with the right dose you can have absolutely incredible trips. I rank my best DXM trips above my LSD trips and most of my mushroom experiences. Its definately different but its far from stupid if you know how to use it.

But then, I only ever took each drug a handful of times and moved on, I didn't use anything excessively..
 
Ok I know this is going to sound like a stupid 'noob' question, but I'm going to ask it anyway. Could one use DXM along with MDMA to potentiate the effects safely? For example could I take 200mg of DXM along with 50mg of MDMA and have a greatly enhanced MDMA experience? Or is this just a stupid idea like using an MAOi to potentiate other drugs?
 
DXM is not an MAOI so no you couldn't do that. DXM/MDMA should never ever be mixed in any quantity. The effects aren't potentiated with the combo btw, its just hitting similar pathways which for whatever reason (I forget the specifics) results in very bad things.

You could, in theory, use an MAOI to potentiate a very very very small dose of MDMA BUT purity, quantity, and adulterants can screw you over big time. Its much safer to just take a regular sized dose of MDMA then potentially overdose because you've got something random in stuff aside from pure MDMA or you who knows what.. Its just too risky.
 
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