Hello, as I'm currently going through a slight withdrawal these kind of questions usually come up into my mind. But most specifically why it feels as though when I go to grab a glass of water from the kitchen I feel as though I'm being hampered by a ball and chain. Or perhaps when I try and get some rest without fidgeting around everywhere I find that I can not.
All these feel as though they are the opposite of what Opioids provide, so does that mean that our beta endorphins are this varied in their jobs in our bodies? I mean all these W/D symptoms are from the neurons being over stimulated along with new neurons being built to take in the initial influx of so much of the substance allowing eventually β-arrestin-2 to show its dirty little head giving us tolerance.
And we also have the fact that when opioids enter the bloodstream the suppress the release of noradrenaline from the locus ceruleus.With repeated exposure to opioids, however, the LC neurons adjust by increasing their level of activity. So with repeated exposure of the opioids the LC responds in kind by increasing its release of NA, making that original dose of opioid seem to feel normal because of the added excitatory NA leading to higher dosages to feel that original opioid feeling. When opioids are not present to suppress the LC brain cells’ enhanced activity, however, the neurons release excessive amounts of NA, triggering jitters, anxiety, muscle cramps, and diarrhea.
So basically what I'm trying to get at is that all the aches and pains and shaking and feeling incredible fatigue, are they all from the simple fact that our endorphin system controls all these fascets of horribleness that we feel during W/D?
Also added in is the NA being upped very high from trying to remain in balance during repeated opioid use. Which I think is why clonidine helps so much during w/d. And ideas or some conversation is welcomed :D as I am a little bored right now and it feels nice to stimulate some thinking.
All these feel as though they are the opposite of what Opioids provide, so does that mean that our beta endorphins are this varied in their jobs in our bodies? I mean all these W/D symptoms are from the neurons being over stimulated along with new neurons being built to take in the initial influx of so much of the substance allowing eventually β-arrestin-2 to show its dirty little head giving us tolerance.
And we also have the fact that when opioids enter the bloodstream the suppress the release of noradrenaline from the locus ceruleus.With repeated exposure to opioids, however, the LC neurons adjust by increasing their level of activity. So with repeated exposure of the opioids the LC responds in kind by increasing its release of NA, making that original dose of opioid seem to feel normal because of the added excitatory NA leading to higher dosages to feel that original opioid feeling. When opioids are not present to suppress the LC brain cells’ enhanced activity, however, the neurons release excessive amounts of NA, triggering jitters, anxiety, muscle cramps, and diarrhea.
So basically what I'm trying to get at is that all the aches and pains and shaking and feeling incredible fatigue, are they all from the simple fact that our endorphin system controls all these fascets of horribleness that we feel during W/D?
Also added in is the NA being upped very high from trying to remain in balance during repeated opioid use. Which I think is why clonidine helps so much during w/d. And ideas or some conversation is welcomed :D as I am a little bored right now and it feels nice to stimulate some thinking.
